High Throughput Toxicological Screening Support

高通量毒理学筛查支持

• 批准号: 10347139
• 负责人: Kristin Aillon
• 金额: $ 67.86万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-18 至 2021-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10347139
• 关键词: Adverse effects; Biological; Chemicals; Chemistry; Contracts; Dermal; Development; Dimethyl Sulfoxide; Dose; Ensure; Environmental Exposure; Equipment and supply inventories; Evaluation; Exposure to; Formulation; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Human; In Vitro; Individual; Methods; NMR Spectroscopy; National Toxicology Program; Organ; Outcome; Policies; Process; Protocols documentation; Research; Risk Assessment; Risk Factors; Services; Ships; Specific qualifier value; Technology; Testing; Toxic effect; Toxicity Tests; Toxicology; Validation; Work; Zebrafish; base; disorder prevention; dose information; expiration; high throughput screening; programs; public health research; screening; sound

The goal of this project is to provide chemistry-based services to support National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing study chemical characterization, including unequivocal identity and purity of the chemicals studied, confirmation of the dose concentrations in administered formulations, and internal dose determinations in multiple biological matrices or target organs in the test species. Information about the identity and purity of study chemicals and the concentration of study chemicals in dose formulations is critical to proper evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species. Confirmed identity and purity, dose concentrations and the information obtained through the work of this contract relating to internal dose, ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. Internal dose information provided by this contract also enables extrapolations to humans to be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该项目的目标是提供基于化学的服务，以支持国家毒理学计划 (NTP) 危害识别活动，旨在预防因环境暴露于化学或物理制剂而引起的疾病或不利影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于识别对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学品。该合同通过提供研究化学特性（包括所研究化学物质的明确身份和纯度、给药制剂中剂量浓度的确认以及内部剂量），有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果。对测试物种的多个生物基质或目标器官进行测定。有关研究化学品的身份和纯度以及剂量配方中研究化学品浓度的信息对于正确评估毒性测试以及得出有关研究化学品在测试物种中的潜在毒性的合理、科学结论至关重要。经确认的身份和纯度、剂量浓度以及通过本合同工作获得的与内部剂量有关的信息，最终支持国家毒理学计划和其他联邦机构的风险评估工作。本合同提供的内部剂量信息还可以对人类进行推断，以便公众能够充分了解因接触所研究化学品而产生的风险因素。