Chemistry Services Supporting Per- and Polyfluoroalkyl Substances (PFAS)

支持全氟烷基物质和多氟烷基物质 (PFAS) 的化学服务

• 批准号: 10551031
• 负责人: Kristin Aillon
• 金额: $ 18.21万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-18 至 2022-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551031
• 关键词: Adverse effects; Agreement; Alcohols; Analytical Chemistry; Biological; Chemicals; Chemistry; Collaborations; Contracts; Coupled; Detection; Development; Dimethyl Sulfoxide; Dose; Ensure; Environmental Exposure; Evaluation; Exposure to; Formulation; Gas Chromatography; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Human; Individual; Manuscripts; Methods; NMR Spectroscopy; National Institute of Environmental Health Sciences; National Toxicology Program; Nuclear Magnetic Resonance; Organ; Outcome; Poly-fluoroalkyl substances; Process; Reporting; Research; Risk Assessment; Risk Factors; Services; Source; Specific qualifier value; Testing; Texas; Toxic effect; Toxicity Tests; Toxicology; United States Environmental Protection Agency; Universities; Work; base; disorder prevention; dose information; perfluorooctane sulfonate; programs; public health research; sound

The goal of this project is to provide chemistry-based services to support National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing study chemical characterization, including unequivocal identity and purity of the chemicals studied, confirmation of the dose concentrations in administered formulations, and internal dose determinations in multiple biological matrices or target organs in the test species. Information about the identity and purity of study chemicals and the concentration of study chemicals in dose formulations is critical to proper evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species. Confirmed identity and purity, dose concentrations and the information obtained through the work of this contract relating to internal dose, ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. Internal dose information provided by this contract also enables extrapolations to humans to be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该项目的目的是提供基于化学的服务，以支持针对预防疾病的危险识别活动（NTP）危害识别活动，或者是由于环境暴露于化学物质或物理药物而引起的不良影响。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学物质。该合同通过提供研究化学表征，包括所研究的化学物质的明确认同和纯度，在多种生物学基质或测试物种中确定剂量浓度的确认，在多种生物学基质或测定内部剂量测定中确认了毒性研究的能力以及其他毒理学结果以及其他毒理学结果的证据。有关研究化学物质的身份和纯度以及剂量制剂中研究化学物质的浓度的信息对于正确评估毒性测试和声音的发展，关于研究物种中研究化学物质的潜在毒性的科学结论至关重要。确认的身份和纯度，剂量浓度以及与内部剂量有关的合同工作获得的信息，最终支持国家毒理学计划和其他联邦机构的风险评估工作。本合同提供的内部剂量信息还可以向人类进行外推，以便可以充分了解公众因暴露于研究化学物质而引起的风险因素。