Project 5: Formation of Hazardous PAH Breakdown Products in Complex Env

项目5：复杂环境中有害PAH分解产物的形成

• 批准号: 9066651
• 负责人: Staci L Simonich
• 金额: $ 30.29万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9066651
• 关键词: Affect; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Availability; Biometry; Bioremediations; Chemicals; Chemistry; Complex; Computer Simulation; Creosote; Gas Chromatography; Health; Human; Instruction; Mass Spectrum Analysis; Measures; Methods; Modeling; Monitor; Oxidants; Parents; Particulate Matter; Peer Review; Property; Research Personnel; Research Support; Review Literature; Risk; Risk Assessment; Sampling; Site; Soil; Structure; Superfund; Technology; Testing; Time; Translational Research; Water; Wood material; Zebrafish; base; data sharing; laboratory experiment; new technology; oxidation; remediation; research study; superfund site; two-dimensional

PROJECT SUMMARY (See instructions): The most common ways to remediate polycyclic aromatic hydrocarbon (PAH) contamination at Superfund sites include chemical oxidation, bioremediation and thermal treatment. All of these remediation strategies have the potential to form hazardous oxy- and hydroxy-PAH breakdown products by oxidizing parent PAH. However, the peer-reviewed literature contains few studies of the formation of these chemicals during PAH remediation, for at least three reasons: the inability to predict which oxy- and hydroxy-PAHs will form in complex environmental mixtures, the complexity of the chemical analysis of oxy- and hydroxy-PAHs, and the historical lack of oxy- and hydroxy-PAH standards. As a result, regulatory agencies and researchers monitor the degradation of parent PAH during remediation of Superfund sites, but not the formation of hazardous PAH breakdown products. We hypothesize that parent PAHs transform into more persistent, water soluble, bioavailable, and toxic PAH breakdown products during the remediation of PAH-contaminated Superfund sites. Our first specific aim is to predict and measure PAH breakdown products formed from the oxidation of parent PAHs on the basis of computational modeling, controlled laboratory experiments, and two-dimensional gas chromatography equipped with time-of-flight mass spectrometry (GCxGC/ToF-MS). Our second specific aim is to measure PAH breakdown products directly in soils and sediments from former wood treatment Superfund sites, pre- and post-remediation, by GCxGC/ToF-MS. Our third specific aim is to determine which PAH remediation technologies minimize the formation of hazardous PAH breakdown products and assess the potential risk. We plan to measure soil and sediment samples from pilot scale remediation testing and determine if the parent, oxy-, and hydroxy-PAH concentrations increase or decrease with testing. We will determine which remediation conditions and soil and sediment properties affect the formation of hazardous PAH breakdown products. We will also collaborate with the Research Translation Core to provide guidance to Superfund managers regarding the human risk assessment of hazardous PAH breakdown products and appropriate remediation strategies to minimize their formation.

项目摘要（请参阅说明）：在超级基金部位补救多环芳烃（PAH）污染的最常见方法包括化学氧化，生物修复和热处理。所有这些补救策略都有可能通过氧化父pah形成危险的氧和羟基-PAH分解产物。然而，经过同行评审的文献很少有关于PAH修复过程中这些化学物质形成的研究，这至少三个原因：无法预测哪些氧和羟基-PAH将在复杂的环境混合物中形成，这是对氧化学分析的复杂性，对氧气和羟基 - PAH的化学分析，以及历史上缺乏氧气和氧PAH和氧气和氧气和氧PAH的标准。结果，监管机构和研究人员在修复超级基金站点期间监测父pah的降解，而不是形成危险的PAH崩溃产品。我们假设父母PAHS转变为在补救PAH污染的超级基金站点期间，更持久，可溶性，生物利用和有毒的PAH分解产物。我们的第一个具体目的是根据计算建模，受控实验室实验和配备有飞行时间质谱时间（GCXGC/TOF-MS）的二维气相色谱法预测和测量由父pahs形成的PAH分解产物。我们的第二个具体目的是通过GCXGC/TOF-MS直接测量来自以前木材处理超级基金的土壤和沉积物中的PAH分解产物。我们的第三个具体目的是确定哪种PAH修复技术最大程度地减少了危险PAH分解产品的形成并评估潜在风险。我们计划通过试验量表修复测试测量土壤和沉积物样品，并确定父，氧和羟基-PAH浓度是否随着测试而增加或减少。我们将确定哪些修复条件以及土壤和沉积物特性会影响危险的PAH分解产物的形成。我们还将与研究翻译核心合作，向超级基金经理提供有关危险PAH分解产品的人类风险评估和适当的补救策略的指导，以最大程度地减少其形成。