Project 5: Formation of Hazardous PAH Breakdown Products in Complex Env

项目5：复杂环境中有害PAH分解产物的形成

• 批准号: 9066651
• 负责人: Staci L Simonich
• 金额: $ 30.29万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9066651
• 关键词: Affect; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Availability; Biometry; Bioremediations; Chemicals; Chemistry; Complex; Computer Simulation; Creosote; Gas Chromatography; Health; Human; Instruction; Mass Spectrum Analysis; Measures; Methods; Modeling; Monitor; Oxidants; Parents; Particulate Matter; Peer Review; Property; Research Personnel; Research Support; Review Literature; Risk; Risk Assessment; Sampling; Site; Soil; Structure; Superfund; Technology; Testing; Time; Translational Research; Water; Wood material; Zebrafish; base; data sharing; laboratory experiment; new technology; oxidation; remediation; research study; superfund site; two-dimensional

PROJECT SUMMARY (See instructions): The most common ways to remediate polycyclic aromatic hydrocarbon (PAH) contamination at Superfund sites include chemical oxidation, bioremediation and thermal treatment. All of these remediation strategies have the potential to form hazardous oxy- and hydroxy-PAH breakdown products by oxidizing parent PAH. However, the peer-reviewed literature contains few studies of the formation of these chemicals during PAH remediation, for at least three reasons: the inability to predict which oxy- and hydroxy-PAHs will form in complex environmental mixtures, the complexity of the chemical analysis of oxy- and hydroxy-PAHs, and the historical lack of oxy- and hydroxy-PAH standards. As a result, regulatory agencies and researchers monitor the degradation of parent PAH during remediation of Superfund sites, but not the formation of hazardous PAH breakdown products. We hypothesize that parent PAHs transform into more persistent, water soluble, bioavailable, and toxic PAH breakdown products during the remediation of PAH-contaminated Superfund sites. Our first specific aim is to predict and measure PAH breakdown products formed from the oxidation of parent PAHs on the basis of computational modeling, controlled laboratory experiments, and two-dimensional gas chromatography equipped with time-of-flight mass spectrometry (GCxGC/ToF-MS). Our second specific aim is to measure PAH breakdown products directly in soils and sediments from former wood treatment Superfund sites, pre- and post-remediation, by GCxGC/ToF-MS. Our third specific aim is to determine which PAH remediation technologies minimize the formation of hazardous PAH breakdown products and assess the potential risk. We plan to measure soil and sediment samples from pilot scale remediation testing and determine if the parent, oxy-, and hydroxy-PAH concentrations increase or decrease with testing. We will determine which remediation conditions and soil and sediment properties affect the formation of hazardous PAH breakdown products. We will also collaborate with the Research Translation Core to provide guidance to Superfund managers regarding the human risk assessment of hazardous PAH breakdown products and appropriate remediation strategies to minimize their formation.

项目摘要（参见说明）：修复超级基金场地多环芳烃 (PAH) 污染的最常见方法包括化学氧化、生物修复和热处理。所有这些修复策略都有可能通过氧化母体 PAH 形成危险的含氧和羟基 PAH 分解产物。然而，同行评审文献很少对 PAH 修复过程中这些化学物质的形成进行研究，这至少有三个原因：无法预测复杂环境混合物中会形成哪些氧基和羟基 PAH、化学分析的复杂性氧-和羟基-PAHs，以及历史上缺乏氧-和羟基-PAH 标准。因此，监管机构和研究人员在超级基金场地修复期间监测母体多环芳烃的降解，但不监测有害多环芳烃分解产物的形成。我们假设，在修复受 PAH 污染的超级基金场地期间，母体 PAH 转化为更持久、水溶性、生物可利用性和毒性的 PAH 分解产物。我们的第一个具体目标是基于计算模型、受控实验室实验和配备飞行时间质谱（GCxGC/ToF-）的二维气相色谱来预测和测量母体 PAH 氧化形成的 PAH 分解产物多发性硬化症）。我们的第二个具体目标是通过 GCxGC/ToF-MS 直接测量修复前和修复后来自前木材处理超级基金场地的土壤和沉积物中的 PAH 分解产物。我们的第三个具体目标是确定哪些 PAH 修复技术可以最大程度地减少有害 PAH 分解产物的形成并评估潜在风险。我们计划通过中试规模的修复测试来测量土壤和沉积物样本，并确定母体、含氧多环芳烃和羟基多环芳烃浓度是否会随着测试而增加或减少。我们将确定哪些修复条件以及土壤和沉积物特性会影响有害多环芳烃分解产物的形成。我们还将与研究翻译核心合作，为超级基金经理提供有关危险多环芳烃分解产品的人类风险评估和适当的补救策略以尽量减少其形成的指导。