BRIDGES for Evaluation of Health Outcomes, Repercussions and Impacts in Zones of

评估健康结果、后果和影响的桥梁

• 批准号: 8195395
• 负责人: Kim A. Anderson
• 金额: $ 10.97万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-22 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195395
• 关键词: Address; Affect; Air; Ames Assay; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Assay; Biological Availability; Chemicals; Collaborations; Communities; Coupled; Data; Detection; Development; Devices; Diagnostic; Disasters; Embryo; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Fingerprint; Florida; Generations; Goals; Grant; Health; Health Professional; Health education; Human; In Situ; Individual; Internet; Life; Louisiana; Measurement; Measures; Methods; Mexico; Modeling; Oils; Online Systems; Outcome; Pattern Recognition; Process; Public Health; Reaction; Relative (related person); Research Project Grants; Risk; Risk Assessment; Sampling; Site; Source; Superfund; System; Technology; Testing; Time; Toxic effect; Uncertainty; Water; Work; Zebrafish; abstracting; analytical tool; chemical spill; environmental stressor; hazard; innovation; microbial; novel; organic contaminant; outreach; response; tool; zebrafish development

Abstract The goals of the proposed project will be to use passive samplers in the Gulf of Mexico before, during and post impact from the Deepwater Horizon Spill of 2010. The passive samplers are biological response indicator devices for gauging environmental stressors (BRIDGES) developed as part of a Superfund Center grant. The devices are air and water passive sampling devices (PSD) that bridge environmental exposure and biological response/effect. They can provide for high throughput samples and rapid turnaround of data. They sequester polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs (OPAHs) as well as other organic contaminants. OPAHs are potentially more mobile, bioavailable and/or persistent than PAHs. There is growing evidence that OPAHs have important toxicological significance. Dispersants that increase bioavailability coupled with sites exposed to UV may increase OPAHs. The use of complementary bioanalytical tools that quantify bioavailability PAH processes is important to understand disasters such as chemical spill risk. Specific Aim 1: Deploy a set of BRIDGES, air and water bio-analytical tools, regionally in the Gulf of Mexico before, during and post impact to quantitatively sequester bioavailable contaminants. Specific Aim 2: Develop discriminatory pattern recognition and multivariate regression assessments of components in PSD extracts and contaminant source type. Specific Aim 3: Utilize the zebrafish developmental model and Ames assay to test the relative potency of pre-, during and post-impact Deepwater Horizon spill BRIDGES extracts. From a translational perspective, a significant data gap currently exists with respect to oxygenated PAHs and the risk assessment process, currently only the 16 priority PAHs in air is EPA's focus. OPAHs are known to be important hazards, the detection and quantification will provide new and very important information on the complexity of the spill that is not currently being captured. The Outreach, in collaboration, will relate environmental health education that applies to the Gulf of Mexico Oil Spill research of the Project and disseminate to individuals working and living in the states along the coastline of the Gulf of Mexico using novel methods including the web.

抽象的 拟议项目的目标将是以前在墨西哥湾使用被动采样器， 在2010年深水地平线溢出中的影响和后影响。被动采样器是 测量环境压力源（桥梁）的生物响应指标设备 作为超级基金中心赠款的一部分开发。设备是空气和水被动采样 设备（PSD）桥梁环境暴露和生物反应/效应。他们可以 提供高吞吐量样本和数据的快速周转。它们隔离了多环 芳族碳氢化合物（PAHS），氧化PAH（OPAH）以及其他有机物 污染物。与PAHS相比，Opahs可能更可移动，生物利用和/或持久。 越来越多的证据表明奥帕斯具有重要的毒理学意义。分散剂 这种增加的生物利用度加上暴露于紫外线的地点可能会增加Opah。使用 量化生物利用度PAH过程的互补生物分析工具对 了解诸如化学溢出风险之类的灾难。特定目标1：部署一组桥梁，空气 和水生物分析工具，在墨西哥湾地区，期间，爆发到墨西哥湾地区 定量隔离生物利用污染物。特定目标2：发展歧视性 PSD提取物中组件分量的模式识别和多元回归评估 和污染物源类型。特定目的3：利用斑马鱼的发展模型和 AMES分析以测试前，期间和影响后深水地平线溢出的相对效力 桥梁提取。从转化的角度来看，目前存在一个重大数据差距 尊重氧化PAH和风险评估过程，目前只有16个优先级 Air中的PAH是EPA的重点。众所周知，奥帕斯是重要的危害，检测和 量化将提供有关泄漏复杂性的新的非常重要的信息 目前尚未被捕获。外展活动将与环境健康联系起来 适用于该项目的墨西哥溢油研究的教育，并传播到 使用小说的人在墨西哥湾的海岸线上工作和生活 包括网络在内的方法。