Project 4: Bridging Superfund Sites Based Based Bioavailable Extract( Anderson)

项目 4：基于生物可利用提取物的桥接超级基金站点（Anderson）

• 批准号: 8695368
• 负责人: Kim A. Anderson
• 金额: $ 31.78万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695368
• 关键词: Address; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Assay; Biological Availability; Biological Effect of Chemicals; Chemicals; Data; Devices; Effectiveness; Face; Fishes; Goals; Health; Human; Instruction; Measures; Membrane; Methods; Metric; Minority; Modeling; Organism; Parents; Process; Public Health; Radiation; Research Personnel; Resolution; Risk; Sampling; Signal Recognition Particle; Site; Superfund; System; Technology; Testing; Tissues; Toxic effect; Viola; Water; Work; analytical tool; base; bioaccumulation; new technology; oxidation; programs; remediation; response; stressor; success; superfund site; tool

PROJECT SUMMARY (See instructions): The organizations that remediate Superfund sites face the challenge of how to measure success; i.e., how to assess the changes in the bioavailability of contaminants.They need quantitative tools that can characterize contaminants and predict their risk to local organisms and humans. Non-chemical factors such as ultra-violet radiation can transform the parent compounds into unmonitored chemicals that can change the toxicity of waters and sediments. To address this issue, we have developed passive sampling devices (PSDs) that can sequester thousands of bioavailable chemicals. These devices can help regulatory agencies to evaluate new remediation technologies that may either produce or release previously unmonitored chemicals. Our PSDs are now sequestering chemicals at multiple Superfund sites, where they capture relevant organic compounds, including hydrophilic and semi-polar contaminants. We propose to test these hypotheses: PSDs sequester realistic and relevant mixtures from Superfund sites. PSDs can help researchers to characterize exposure accurately. PSDs can simplify toxicity assessments. PSDs can evaluate the effectiveness of remediation, considering not only the target contaminants but also any perturbations of the system that the remediation technologies may have induced. PSDs can serve as biological surrogates in public health assessments of Superfund sites. We propose to develop a set of widely applicable bio-analytical tools. We will integrate these tools with bioassays to characterize Superfund sediments. We assume that a small minority of the chemicals at Superfund sites are responsible for the majority of the toxicity. We will apply stressors to PSD extracts and characterize the chemical and biological effects. We will deliver methods and tools to assess the impact of non-chemical/chemical stressors that act on Superfund mixtures during natural transformation processes and remediation. We will develop PSD-bioaccumulation models that can predict chemical load in aquatic tissues with useful accuracy on the basis of measured PSD extracts. The ability to predict aquatic tissues from PSD extracts will enable Superfund managers and public health officials to collect data with better temporal and spatial resolution.

项目摘要（请参阅说明）：补救超级基金站点的组织面临如何衡量成功的挑战；即，如何评估污染物的生物利用度变化。它们需要定量工具，以表征污染物并预测其对当地生物体和人类的风险。非化学因素（例如超紫外线辐射）可以将母体化合物转化为可以改变水和沉积物毒性的无监测化学物质。为了解决这个问题，我们开发了被动抽样设备（PSD），可以隔离数千种生物利用化学物质。这些设备可以帮助监管机构评估可能生产或释放先前未经监视化学物质的新补救技术。我们的PSD现在正在多个超级基金位点进行隔离化学物质，它们在其中捕获相关的有机化合物，包括亲水性和半极性污染物。我们建议检验这些假设：PSD隔离了超级基金站点的现实和相关混合物。 PSD可以帮助研究人员准确表征暴露。 PSD可以简化毒性评估。 PSD不仅可以评估补救措施的有效性，不仅要考虑到目标污染物，而且考虑了补救技术可能引起的系统的任何扰动。 PSD可以在超级基金站点的公共卫生评估中充当生物替代物。我们建议开发一组广泛适用的生物分析工具。我们将将这些工具与生物测定器集成在一起，以表征超级基金沉积物。我们假设超级基金站点的少数化学物质是造成大部分毒性的原因。我们将在PSD提取物上应用压力源，并表征化学和生物学作用。我们将提供方法和工具来评估在自然转化过程和修复过程中对超级基金混合物作用的非化学/化学应激源的影响。我们将开发PSD生物蓄能模型，这些模型可以根据测量的PSD提取物来预测具有有用精度的水生组织中的化学负荷。从PSD提取物中预测水生组织的能力将使超级基金经理和公共卫生官员能够以更好的时间和空间分辨率收集数据。