Oklahoma Center for Respiratory and Infectious Diseases

俄克拉荷马州呼吸和传染病中心

• 批准号: 10215542
• 负责人: LIN LIU
• 金额: $ 223.38万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215542
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Animal Model; Applications Grants; Area; Award; Centers of Research Excellence; Collaborations; Communicable Diseases; Communities; Core Facility; Development; Disease; Faculty; Financial Support; Foundations; Funding; Goals; Grant; Health Sciences; Infectious Diseases Research; Influenza; Institutes; Institution; Journals; Leadership; Lung diseases; Lung infections; Malignant Neoplasms; Medical Research; Medicine; Mentors; Mentorship; Modernization; Molecular Biology; Nature; Oklahoma; Paper; Phase; Pilot Projects; Pneumonia; Population; Positioning Attribute; Program Research Project Grants; Pseudomonas aeruginosa; Publishing; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Respiratory Center; Respiratory Tract Infections; Scientist; Series; Services; Streptococcus pneumoniae; Talents; Technology; United States National Institutes of Health; Universities; Viral; bench to bedside; burden of illness; college; combat; drug development; immunopathology; improved; influenzavirus; innovation; inter-institutional; interdisciplinary collaboration; meetings; member; multidisciplinary; new technology; prevent; programs; public health priorities; recruit; respiratory; success; tenure track

PROJECT SUMMARY This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from major research institutions across the state of Oklahoma, including 10 colleges at Oklahoma State University (OSU) and the University of Oklahoma (OU), as well as an independent research institute, the Oklahoma Medical Research Foundation (OMRF). OCRID is unified by a commitment to excellence in research and training in respiratory and infectious diseases. Our scientists and leadership cultivate excellence through deliberate faculty mentorship, robust interdisciplinary collaboration, innovative research, and a dynamic bench-to-bedside-to-marketplace approach. As the first CoBRE grant ever received by OSU, the Phase I award has made a transformative change in the research landscape on respiratory infectious disease research in Oklahoma. Building on the success of the Phase I award, the overall objective of this Phase II CoBRE application is to build a sustainable research center of excellence in the field of respiratory and infectious diseases. Of the four Phase II research projects on respiratory infectious diseases in this application led by four talented and promising junior investigators, two focus on influenza virus, one on Streptococcus pneumonia and one on Pseudomonas aeruginosa. Aim 1 will expand the critical mass of multi-disciplinary investigators in the thematic area of respiratory infectious diseases. This aim will be accomplished by 1) mentoring four Phase II project leaders to become NIH-funded independent investigators; 2) hiring at least 4 new tenure-track faculty members whose research is within the focus of the Center; 3) nurturing junior investigators and re-directing established investigators into respiratory infectious disease research via a pilot project program; and 4) recruiting and mentoring replacement project leaders after the current Phase II project leaders rotate out after the initial 2-3 years of support. Aim 2 will further develop the research infrastructure by strengthening three unique research cores (Animal Models, Immunopathology, and Molecular Biology). Aim 3 will enhance inter-institutional collaborations in Oklahoma to develop a self-sustainable respiratory and infectious research center. The further development of OCRID via this Phase II CoBRE will have even greater positive impact on respiratory and infectious disease research in the state of Oklahoma and will sustain the only Center of its kind in Oklahoma.

项目摘要 这项II阶段应用程序寻求支持以进一步发展俄克拉荷马州中心 呼吸道和传染病（OCRID）成为可持续研究的卓越中心。已确立的 在2013年通过第一阶段的毛赠金，Ocrid迅速成为扩大呼吸系统的焦点 俄克拉荷马州的传染病研究。 OCRID的研究人员来自主要研究机构 俄克拉荷马州，包括俄克拉荷马州立大学（OSU）的10所大学和大学 俄克拉荷马州（OU）以及俄克拉荷马州医学研究基金会的独立研究所 （OMRF）。 Ocrid通过致力于卓越的呼吸和传染性研究和培训的承诺而统一 疾病。我们的科学家和领导力通过故意的教师指导，鲁棒来培养卓越 跨学科的合作，创新研究以及动态的基准对床位到市场的方法。 作为OSU有史以来的第一批毛线赠款，第一阶段奖已经对 研究俄克拉荷马州呼吸道传染病研究的局势。建立在成功的基础上 第一阶段奖，这一II阶段毛线应用程序的总体目标是建立可持续研究 呼吸道和传染病领域的卓越中心。在四阶段研究项目中 该应用程序中的呼吸道传染病由四名才华横溢且有前途的初级调查员，两个 专注于流感病毒，一种在肺炎链球菌上，一种是铜绿假单胞菌。目标1意志 扩大呼吸道传染性主题领域的多学科研究人员的临界质量 疾病。这个目标将通过1）指导四个阶段项目领导者成为NIH资助 独立调查员； 2）至少雇用4个新的终身教师 中心的重点； 3）培养初级调查人员并将既定的研究人员重新指导到呼吸道 通过试点项目计划的传染病研究； 4）招募和指导替代项目 最初2 - 3年的支持后，当前II期项目领导者之后的领导者旋转。 AIM 2意志 通过加强三个独特的研究核心（动物模型， 免疫病理学和分子生物学）。 AIM 3将增强俄克拉荷马州的机构间合作 建立一个自我维持的呼吸和传染性研究中心。 Ocrid的进一步发展 该第二阶段的毛绒将对呼吸道和传染病研究产生更大的积极影响 俄克拉荷马州，将维持俄克拉荷马州唯一的同类中心。