Data Center for Acute to Chronic Pain Biosignatures

急性至慢性疼痛生物特征数据中心

• 批准号: 9812376
• 负责人: Martin Lindquist
• 金额: $ 29.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9812376
• 关键词: Acute; Awareness; Behavior; Behavior assessment; Behavioral; Biometry; Cellular Phone; Clinical; Clinical Data; Cloud Computing; Code; Collaborations; Communication; Communities; Computer software; Country; Custom; Data; Data Analyses; Data Quality; Data Science; Data Scientist; Data Set; Data Storage and Retrieval; Databases; Development; Education; Educational workshop; Electronic Health Record; Enrollment; Environment; Epidemic; Faculty; Funding; Gap Junctions; Genomics; High Performance Computing; Image; Imagery; Informatics; Infrastructure; Institution; Internet; Intranet; Lead; Machine Learning; Measures; Metadata; Methods; Modeling; Pain; Patients; Peripheral; Persons; Physiology; Process; Productivity; Proteomics; Protocols documentation; Pythons; Quality Control; Recording of previous events; Research Personnel; Resources; Rest; Running; Science; Scientist; Sensory; Side; Software Engineering; Standardization; Structure; System; Testing; Texas; Training; Training Programs; United States National Institutes of Health; Universities; Update; Wages; Wearable Computer; Work; analysis pipeline; base; biosignature; chronic pain; clinical pain; cloud based; cluster computing; cyber infrastructure; data access; data integration; data pipeline; data portal; data resource; data submission; deep learning; design; electronic book; experience; health data; massive open online courses; meetings; member; multimodal data; neuroimaging; online course; opioid use; outreach; outreach program; pain model; predictive modeling; programs; prospective; response; skills; social media; statistics; tool; user-friendly

Understanding the mechanisms underlying the transition to chronic pain is a key to mitigating the dual epidemics of chronic pain and opioid use in the U.S. In response to RFA-RM-18-031, and as part of the NIH Common Fund Acute to Chronic Pain Signatures (A2CPS) Program, we will establish a Data Integration and Resource Center (DIRC) to integrate imaging, physiology, -omics, behavioral, and clinical data to develop biosignatures for the transition to chronic pain. The Center will be based in the Department of Biostatistics at JHU, a nexus for a wide range of collaborators with expertise in (1) advanced data science and machine learning, (2) neuroimaging, (3) genomics and related -omics, (4) wearable computing and smartphone-based behavioral assessment, (5) systems-level predictive biosignatures, (6) software engineering and high-performance computing, and (7) world-renowned pain researchers from JHU and other institutions. JHU Biostatistics is the top-ranked department of its kind in the country, and its unique blend of faculty provides the ability to be nimble and accommodate analysis of diverse data types as needed, and a unique capacity for scientific outreach through online courses and other forums. To deliver computing infrastructure and cloud-based computing for A2CPS, we partner with the Texas Advanced Computing Center (TACC), who have a long track record of large-scale collaborations and have already built many of the cloud computing tools we see as ideal for this project. The Center will consist of three components and an Administrative Core. The Administrative Core will lead the Center and facilitate interaction among the components of the Center and across the A2CPS consortium. The Data Coordination Component (DCC) will provide the infrastructure for storage and processing, analysis pipelines, cloud computing, and portals for data upload/query/export, in addition to other technical deliverables. The Data Integration and Analysis Component (DIAC) will provide data type-specific content for pipelines and analyses of data collected by the A2CPS consortium. The Scientific Outreach Component (SOC) will use DCC- developed portal infrastructure to maintain the consortium intranet and perform outreach via the public A2CPS portal. It will also organize a variety of in-person and online training and outreach programs, including the creation of free, online courses disseminating information about chronic pain and A2CPS tools, data, and models.

了解过渡到慢性疼痛的机制是 缓解美国慢性疼痛和阿片类药物使用的双重流行 RFA-RM-18-031，作为NIH共同基金的一部分，慢性疼痛 签名（A2CPS）程序，我们将建立数据集成和资源中心 （DIRC）整合成像，生理学， - 组，行为和临床数据以发展 过渡到慢性疼痛的生物签名。该中心将基于 JHU生物统计学系，与广泛合作者的联系 （1）高级数据科学和机器学习方面的专业知识，（2）神经影像学，（3） 基因组学及相关 - （4）可穿戴计算和基于智能手机的行为 评估，（5）系统级预测生物签名，（6）软件工程和 高性能计算以及（7）JHU和 其他机构。 JHU生物统计学是同类产品中排名第一的部门 国家及其独特的教师融合提供了敏捷和 根据需要适应各种数据类型的分析，并具有独特的能力 通过在线课程和其他论坛的科学宣传。提供计算 为A2CPS的基础架构和基于云的计算，我们与德克萨斯州合作 高级计算中心（TACC），他们的大规模记录很长 协作，已经构建了许多我们认为是理想的云计算工具 对于这个项目。该中心将由三个组件和一个管理核心组成。 行政核心将领导中心，并促进 中心的组成部分以及整个A2CPS联盟。数据协调 组件（DCC）将提供用于存储和处理的基础架构，分析 除其他 技术可交付成果。数据集成和分析组件（DIAC）将 提供针对管道的数据类型的内容，并分析由 A2CPS联盟。科学外展部分（SOC）将使用DCC- 开发了门户基础设施以维持联盟内部网络并进行外展 通过公共A2CPS门户。它还将组织各种面对面和在线培训 和外展计划，包括创建免费的在线课程 有关慢性疼痛和A2CPS工具，数据和模型的信息。