Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort & Biobank

密歇根狼疮流行病学

• 批准号: 9313640
• 负责人: Emily Catherine Somers
• 金额: $ 95.68万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9313640
• 关键词: Michigan; Lupus; Epidemiology; Surveillance; MILES

PROJECT SUMMARY/ABSTRACT This proposal is to continue longitudinal follow-up of the population-based Michigan Lupus Epidemiology & Surveillance (MILES) Program Cohort and Biobank. The overarching goal is to prospectively collect data and biospecimens that will allow for comprehensive investigations related to risk factors for lupus onset, progression, and comorbidities. To date, the baseline round of Cohort visits has been completed, and the first follow-up round of visits is ongoing. Detailed data collection encompasses measures related to sociodemographics, health/wellness, reproductive health, physical function, environmental exposures, lifestyle factors, and genetics. Lupus-specific measures, including disease activity indices, are measured for the SLE cases. The state-of-the-art biobank includes serum, plasma, DNA/RNA (from lymphocyte subsets), urine, hair, and toenail clippings. Biobank specimens are processed and stored in appropriate conditions to provide the capacity to perform assays including contemporary immunoassays, biomarkers of disease and exposure, and DNA methylation of relevant lymphocyte subsets. Major thematic areas that the MILES Cohort & Biobank is designed to support include epigenetics, environmental epidemiology, and renal lupus. The MILES Cohort will thus serve as a robust platform for ongoing and future research investigations that are relevant to the full spectrum of lupus and its complications.

项目概要/摘要 该提案旨在继续对基于人群的密歇根狼疮流行病学进行纵向随访 监测 (MILES) 计划队列和生物样本库。总体目标是前瞻性地收集数据并 生物样本将允许对狼疮发病的危险因素进行全面的调查， 进展和合并症。迄今为止，队列访问的基线轮次已经完成，第一轮 后续轮访正在进行中。详细的数据收集包括以下方面的措施： 社会人口统计学、健康/保健、生殖健康、身体机能、环境暴露、生活方式 因素、遗传因素。针对 SLE 测量狼疮特异性指标，包括疾病活动指数 案例。最先进的生物库包括血清、血浆、DNA/RNA（来自淋巴细胞亚群）、尿液、头发、 和剪下来的脚趾甲。生物样本库样本在适当的条件下进行处理和储存，以提供 进行分析的能力，包括当代免疫分析、疾病和暴露的生物标志物，以及 相关淋巴细胞亚群的 DNA 甲基化。 MILES 队列和生物库的主要主题领域 旨在支持表观遗传学、环境流行病学和肾狼疮。 MILES 队列将 因此，可以作为一个强大的平台，进行与全面相关的正在进行和未来的研究调查。 狼疮谱系及其并发症。