Michigan Lupus Epidemiology and Surveillance (MILES) Program Longitudinal Cohort & Biobank

密歇根狼疮流行病学和监测 (MILES) 计划纵向队列

• 批准号: 10201405
• 负责人: Emily Catherine Somers
• 金额: $ 90万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201405
• 关键词: Michigan; Lupus; Epidemiology; Surveillance; MILES

PROJECT SUMMARY/ABSTRACT This proposal is to continue longitudinal follow-up of lupus cases and controls in the population-based Michigan Lupus Epidemiology & Surveillance (MILES) Program Cohort and Biobank. The overarching goal is to prospectively collect data and biospecimens that will allow for comprehensive investigations of risk factors related to lupus and disease progression, as well as underlying disparities. We are currently in a third wave of cohort study visits. Detailed data collection encompasses measures related to four core content areas: natural history, treatment, healthcare access and disparities. The state-of-the-art biobank includes whole blood, serum, plasma, DNA/RNA (from lymphocyte subsets), urine, hair, and toenail clippings. Biobank specimens are processed and stored in appropriate conditions to provide the capacity to perform assays including contemporary immunoassays, biomarkers of disease and exposures, genotyping, and DNA methylation of relevant lymphocyte subsets. Major thematic areas that the MILES Cohort & Biobank is designed to support include environmental and nutritional epidemiology, epigenetics, and health services research. The MILES Cohort will thus serve as a robust platform for ongoing and future research investigations that are relevant to the full spectrum of lupus and its complications.

项目概要/摘要 该提案旨在继续对基于人群的狼疮病例和控制进行纵向随访。 密歇根狼疮流行病学和监测 (MILES) 计划队列和生物库。总体目标是 前瞻性地收集数据和生物样本，以便对风险因素进行全面调查 与狼疮和疾病进展以及潜在的差异有关。我们目前正处于第三波 队列研究访问。详细的数据收集包括与四个核心内容领域相关的措施： 自然史、治疗、医疗保健获取和差异。最先进的生物库包括整个 血液、血清、血浆、DNA/RNA（来自淋巴细胞亚群）、尿液、头发和剪下的脚趾甲。生物样本库 样本在适当的条件下进行处理和储存，以提供进行分析的能力 包括当代免疫测定、疾病和暴露的生物标志物、基因分型和 DNA 相关淋巴细胞亚群的甲基化。 MILES 队列和生物库的主要主题领域 旨在支持包括环境和营养流行病学、表观遗传学和卫生服务 研究。因此，MILES 队列将成为正在进行和未来研究的强大平台 与全谱狼疮及其并发症相关的研究。