MUSCLE PROTEIN & AGING

肌肉蛋白

• 批准号: 6665907
• 负责人: KE YARASHESKI
• 金额: $ 15.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665907
• 关键词: animal tissue; biological products; biomedical resource; lipids; spectrometry

Advancing age is associated with a reduction in skeletal muscle protein and muscle strength; a syndrome referred to as sarcopenia. Skeletal muscle protein turnover can be studied by infusion of stable isotopically labeled amino acids and mass spectrometry. The reduction in muscle strength with aging results in physical disability and frailty, a loss of independent function, and contributes to escalating health care costs. Support from the NIA and other beneficent organizations (AARP, AFAR, Andrus Foundation, Allied-Signal) has accelerated research breakthroughs, progress, and our understanding of the mechanisms of muscle protein wasting in advancing age. Several new discoveries have enhanced our appreciation of the intricacies of muscle physiology that regulate muscle protein mass and contractile function.

年龄增长与骨骼肌减少有关 蛋白质和肌肉力量；一种称为肌肉减少症的综合征。 骨骼肌蛋白周转可以通过输注稳定的 同位素标记的氨基酸和质谱。 减少 随着年龄的增长，肌肉力量会下降，导致身体残疾， 虚弱，丧失独立功能，并导致升级 医疗保健费用。 NIA 和其他慈善机构的支持 组织（AARP、AFAR、Andrus 基金会、Allied-Signal） 加速研究突破、进展和我们对 随着年龄增长肌肉蛋白质消耗的机制。 一些 新的发现增强了我们对错综复杂的认识 调节肌肉蛋白质质量和收缩的肌肉生理学 功能。