FRACTIONAL SYNTHESIS RATES OF MIXED MUSCLE PROTEININ YOUNG & ELDERLY MEN & WOMEN

年轻混合肌肉蛋白的分数合成率

• 批准号: 6486784
• 负责人: KE YARASHESKI
• 金额: $ 15.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6486784
• 关键词: animal tissue; biomedical resource; diabetes mellitus; endocrine gland /system; hormones; lipids; minerals; spectrometry

We have previously reported that the fractional synthesis rate of vastus lateralis mixed muscle protein (MMP) is lower in elderly than in young adults, although the effect of age upon the synthesis rate of individual contractile proteins was not examined. We used a constant intravenous infusion of [13C]leucine to determine the in vivo rate of amino acid incorporation into vastus lateralis MMP, myosin heavy chain (MHC), and actin in 23-30 yr old healthy, sedentary women and men (n=6) and in 78-84 yr old healthy, sedentary men and women (n=4). In general, lower MMP, MHC, and actin synthesis rates were found in the elderly, although the relative differences in the synthesis rates of individual proteins were not proportional between the two age groups. These results suggest that age-related decrements in contractile protein synthesis rates do not occur uniformly across these muscle proteins.

我们之前报道过，分步合成率 老年人股外侧肌混合肌蛋白（MMP）低于老年人 在年轻人中，尽管年龄对合成率的影响 没有检查单个收缩蛋白。 我们使用了一个常数 静脉输注[13C]亮氨酸以确定体内速率 氨基酸掺入股外侧肌 MMP、肌球蛋白重链 (MHC) 和肌动蛋白（23-30 岁健康、久坐的女性和男性） (n=6) 和 78-84 岁健康、久坐的男性和女性 (n=4)。 在 一般而言，MMP、MHC 和肌动蛋白合成率较低 老年人，尽管合成率的相对差异 两个年龄组之间的个体蛋白质不成比例。 这些结果表明，与年龄相关的收缩力下降 这些肌肉的蛋白质合成率并不均匀 蛋白质。