Towards the clinical testing of dsRNA to promote wound induced hair neogenesis

进行 dsRNA 促进伤口诱导毛发新生的临床测试

基本信息

批准号：
9102384
负责人：
Luis Andres Garza
金额：
$ 35.86万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9102384
关键词：
Affect Aftercare Agonist Back Biological Assay Biological Models CD 200 Cells Cicatrix Clinical Clinical Trials Dermal Diagnostic Double-Stranded RNA Embryonic Development Fatty acid glycerol esters Fibroblasts Fibrosis Frequencies Frozen Sections Gene Expression Genes Genetic Goals Grant Hair Hair follicle structure Healed Health Heart Histology Human IL6ST gene Immunologic Adjuvants In Vitro Injury Interleukin-6 Intervention Kidney Knock-out Knockout Mice Learning Ligands Liver Location Lung Mammals Measures Medicine Messenger RNA Monitor Morphogenesis Mouse Strains Mus Muscle Myocardial Infarction Nanotubes Natural regeneration Organ Organogenesis Pathway interactions Pharmaceutical Preparations Physiological Poly I-C Process Pulmonary Fibrosis Punch Biopsy Recreation Recurrence Research Research Personnel STAT3 gene Scalp structure Signal Transduction Site Skin Spottings Staining method Stains Stem cells Stratum Basale Structure TLR3 gene Testing Time Tissues Transcript Variant Wound Healing Xenograft Model chronic wound cytokine receptor gp130 healing heart function human subject in vivo indexing injured interest keratinocyte knock-down loss of function macrophage mouse model non-invasive imaging novel prevent public health relevance receptor research clinical testing response subcutaneous tongue papilla wound

项目摘要

DESCRIPTION (provided by applicant): The long term objective of the proposed research is to learn what controls whether injuries heal with scarring/fibrosis versus full regeneration of los structures. The human health burden of fibrosis and scarring is enormous and affects every tissue from heart (lost heart function after a myocardial infarction) to lung (idiopathic lung fibrosis). Enhancing regeneration could prevent for example the almost universal recurrence of chronic wounds in the exact location where they previously appeared. We use the Wound Induced Hair Neogenesis (WIHN) model system where in the center of excisional wounds in mice a variable amount of regeneration occurs and de novo hair follicles form in a recapitulation of embryogenesis. The goal of this grant is to understand the factors which control the frequency of regeneration. We will directly test the mechanism and the ability for candidate molecules which enhance regeneration in mice to do so in human subjects. The results of this grant promise to help define new treatments and diagnostics to enhance regeneration and wound healing.

描述（由申请人提供）：拟议研究的长期目标是了解是什么控制损伤是否通过疤痕/纤维化愈合，而不是完全再生。纤维化和疤痕对人类健康造成的负担是巨大的，并影响心脏的每个组织。（心肌梗塞后丧失心脏功能）到肺部（特发性肺纤维化），例如，增强再生可以防止慢性伤口在我们之前出现的位置上几乎普遍复发。伤口诱导毛发新生（WIHN）模型系统，在小鼠切除伤口的中心发生不同数量的再生，并在胚胎发生的再现中从头形成毛囊。这项资助的目的是了解控制毛发新生的因素。我们将直接测试候选分子在人类受试者中增强再生的机制和能力，这项资助的结果有望帮助确定新的治疗和诊断方法，以增强再生和伤口愈合。