Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention

胎儿乙醇引起的行为缺陷：机制、诊断和干预

• 批准号: 9497741
• 负责人: Daniel D. Savage
• 金额: $ 159.45万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9497741
• 关键词: Achievement; Address; Advisory Committees; Affect; Alcohols; Applications Grants; Area; Award; Behavioral; Biological Markers; Brain; Brain Injuries; Child; Cities; Clinical; Clinical Sciences; Collaborations; Communication; Community Outreach; Complement; Coupled; Development; Diagnosis; Ensure; Environment; Ethanol; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Fetus; Goals; Grant; Health Sciences; Individual; International; Intervention; Investigation; Knowledge; Lead; Leadership; Life; Light; Mentors; Methods; National Institute on Alcohol Abuse and Alcoholism; New Mexico; Outcome; Peer Group; Phase; Philosophy; Pilot Projects; Procedures; Recording of previous events; Research; Research Activity; Research Personnel; Risk; Science; Scientist; Series; Teratogens; Training; Training Programs; Translational Research; Universities; Work; alcohol consumption during pregnancy; alcohol exposure; alcohol measurement; alcohol research; biobehavior; clinical investigation; diagnostic biomarker; effective intervention; expectation; faculty mentor; fetal; graduate student; laboratory experience; meetings; neurobehavioral; neurobiological mechanism; neuroimaging; novel; pre-clinical; programs; public health relevance; recruit; symposium; tool; undergraduate student; web page

DESCRIPTION (provided by applicant): NMARC is a NIAAA-designated Developmental Alcohol Research P20 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center's research environment and is facilitating progress towards the achievement of NMARC's three strategic objectives. These objectives are to: 1) Advance our understanding of the teratogenic consequences of fetal alcohol exposure that cause functional brain damage leading to adverse neurobehavioral outcomes. 2) Develop more effective approaches for diagnosing individuals with FASD through the establishment of more sensitive and reliable alcohol biomarkers of alcohol exposure coupled with the use of novel neurobehavioral and functional neuroimaging assessments that can detect functional brain damage earlier in life. 3) Develop more effective neurobehavioral, educational and pharmacotherapeutic interventions tor fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for FASD. This P50 grant application contains five research components, each consisting of teams of investigators whose project addresses one or more of NMARC's three strategic objectives. Three core components support the center's research program: 1) A Pilot Project Core with one clinical and two preclinical projects led by investigators new to the FASD research field. 2) A Science Core that supports all NMARC investigators and serves as a forum for catalyzing collaboration and peer group mentoring. 3) An Administrative Core that will provide scientific and administrative leadership for the entire NMARC program along with administrative support and budgetary oversight of the center programs. The Administrative Core will also be responsible for ensuring progress toward achieving the center's goals of building research capacity through the recruitment of other UNM faculty and new faculty hires, and enhancing our knowledge dissemination capabilities. Assessment of NMARC's progress and achievements will be the responsibility of the Steering Committee working in conjunction with an external Program Advisory Committee of seven internationally-renowned FASD scientists, who will advise and assess NMARC's research activities and progress towards the achievement of the center's goals and strategic objectives.

描述（由申请人提供）：NMARC 是 NIAAA 指定的位于 UNM 健康科学中心的发育性酒精研究 P20 中心。该中心由具有合作研究互动历史的临床前和临床科学家团队组成，他们的专业知识和贡献使该中心的研究环境产生了协同作用，并正在促进实现 NMARC 的三个战略目标。这些目标是： 1) 加深我们对胎儿酒精暴露的致畸后果的理解，这种后果会导致功能性脑损伤，从而导致不良的神经行为结果。 2) 通过建立更敏感和更可靠的酒精暴露生物标志物，并使用可以在生命早期检测功能性脑损伤的新型神经行为和功能性神经影像评估，开发更有效的方法来诊断患有 FASD 的个体。 3) 针对胎儿酒精相关行为缺陷制定更有效的神经行为、教育和药物治疗干预措施。 NMARC 的普遍理念是，一个研究中心的组织目标是最大限度地跨多个临床前和临床研究领域进行协调、沟通和协同整合，为实现更好的诊断和更有效的干预措施的双重临床目标取得重大进展提供最佳的长期前景。胎儿酒精谱系障碍。该 P50 拨款申请包含五个研究部分，每个部分由研究人员团队组成，其项目涉及 NMARC 的三个战略目标中的一个或多个。该中心的研究计划由三个核心组成部分支持：1) 一个试点项目核心，其中包括一个临床项目和两个临床前项目，由 FASD 研究领域的新研究人员领导。 2) 科学核心，支持所有 NMARC 研究人员，并作为促进合作和同行小组指导的论坛。 3) 行政核心，将为整个 NMARC 计划提供科学和行政领导，并为中心计划提供行政支持和预算监督。行政核心还将负责确保通过招聘其他新墨西哥大学教职人员和新聘用的教职人员来实现该中心建设研究能力的目标，并提高我们的知识传播能力。对 NMARC 的进展和成就的评估将由指导委员会与由七名国际知名 FASD 科学家组成的外部项目咨询委员会共同负责，他们将建议和评估 NMARC 的研究活动以及实现中心目标和战略的进展。目标。