Fetal ethanol-induced behavioral deficits: Mechanisms, diagnosis and Intervention

胎儿乙醇引起的行为缺陷：机制、诊断和干预

• 批准号: 9242967
• 负责人: Daniel D. Savage
• 金额: $ 6.2万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9242967
• 关键词: Achievement; Address; Advisory Committees; Affect; Alcohols; Applications Grants; Area; Award; Behavioral; Biological Markers; Brain; Brain Injuries; Child; Cities; Clinical; Clinical Sciences; Collaborations; Communication; Community Outreach; Complement; Coupled; Development; Diagnosis; Ensure; Environment; Ethanol; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Fetus; Goals; Grant; Health; Health Sciences; Individual; Intervention; Investigation; Knowledge; Lead; Leadership; Life; Light; Mentors; Methods; National Institute on Alcohol Abuse and Alcoholism; New Mexico; Outcome; Peer Group; Phase; Philosophy; Pilot Projects; Procedures; Recording of previous events; Research; Research Activity; Research Personnel; Risk; Science; Scientist; Series; TNFRSF5 gene; Training; Training Programs; Translational Research; Universities; Work; alcohol consumption during pregnancy; alcohol exposure; alcohol research; clinical investigation; diagnostic biomarker; effective intervention; expectation; faculty mentor; fetal; graduate student; laboratory experience; meetings; neurobehavioral; neurobiological mechanism; neuroimaging; novel; pre-clinical; programs; symposium; tool; undergraduate student; web page; Achievement; Address; Advisory Committees; Affect; Alcohols; Applications Grants; Area; Award; Behavioral; Biological Markers; Brain; Brain Injuries; Child; Cities; Clinical; Clinical Sciences; Collaborations; Communication; Community Outreach; Complement; Coupled; Development; Diagnosis; Ensure; Environment; Ethanol; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Fetus; Goals; Grant; Health; Health Sciences; Individual; Intervention; Investigation; Knowledge; Lead; Leadership; Life; Light; Mentors; Methods; National Institute on Alcohol Abuse and Alcoholism; New Mexico; Outcome; Peer Group; Phase; Philosophy; Pilot Projects; Procedures; Recording of previous events; Research; Research Activity; Research Personnel; Risk; Science; Scientist; Series; TNFRSF5 gene; Training; Training Programs; Translational Research; Universities; Work; alcohol consumption during pregnancy; alcohol exposure; alcohol research; clinical investigation; diagnostic biomarker; effective intervention; expectation; faculty mentor; fetal; graduate student; laboratory experience; meetings; neurobehavioral; neurobiological mechanism; neuroimaging; novel; pre-clinical; programs; symposium; tool; undergraduate student; web page

DESCRIPTION (provided by applicant): NMARC is a NIAAA-designated Developmental Alcohol Research P20 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center's research environment and is facilitating progress towards the achievement of NMARC's three strategic objectives. These objectives are to: 1) Advance our understanding of the teratogenic consequences of fetal alcohol exposure that cause functional brain damage leading to adverse neurobehavioral outcomes. 2) Develop more effective approaches for diagnosing individuals with FASD through the establishment of more sensitive and reliable alcohol biomarkers of alcohol exposure coupled with the use of novel neurobehavioral and functional neuroimaging assessments that can detect functional brain damage earlier in life. 3) Develop more effective neurobehavioral, educational and pharmacotherapeutic interventions tor fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for FASD. This P50 grant application contains five research components, each consisting of teams of investigators whose project addresses one or more of NMARC's three strategic objectives. Three core components support the center's research program: 1) A Pilot Project Core with one clinical and two preclinical projects led by investigators new to the FASD research field. 2) A Science Core that supports all NMARC investigators and serves as a forum for catalyzing collaboration and peer group mentoring. 3) An Administrative Core that will provide scientific and administrative leadership for the entire NMARC program along with administrative support and budgetary oversight of the center programs. The Administrative Core will also be responsible for ensuring progress toward achieving the center's goals of building research capacity through the recruitment of other UNM faculty and new faculty hires, and enhancing our knowledge dissemination capabilities. Assessment of NMARC's progress and achievements will be the responsibility of the Steering Committee working in conjunction with an external Program Advisory Committee of seven internationally-renowned FASD scientists, who will advise and assess NMARC's research activities and progress towards the achievement of the center's goals and strategic objectives.

描述（由申请人提供）：NMARC是UNM Health Sciences Center的NIAAA指定的开发性酒精研究P20中心。该中心由临床前和临床科学家团队组成，具有协作研究史的历史，其专业知识和贡献使中心的研究环境协同，并促进了实现NMARC的三个战略目标的进步。这些目标是：1）提高我们对胎儿酒精暴露的致致致造性后果的理解，从而导致功能性脑损伤，导致神经行为不良。 2）通过建立更敏感和可靠的酒精暴露饮酒生物标志物，再加上新型的神经行为和功能性神经影像学评估，从而开发出更有效的方法来诊断FASD的个体，从而可以检测到生命中早期的功能性脑损伤。 3）开发更有效的神经行为，教育和药物治疗干预措施与胎儿酒精相关的行为缺陷。 NMARC的流行哲学是，一个组织中心，旨在最大程度地提高临床前和临床研究的多种线路的协调，交流和协同整合，这为实现了更好的长期前景，以取得重大进展，以实现更好的诊断和更有效的FASD干预措施的双重临床目标。该P50赠款应用程序包含五个研究组件，每个研究组件由调查人员团队组成，其项目涉及NMARC的三个战略目标中的一个或多个。三个核心组件支持该中心的研究计划：1）一个试点项目核心，其中一个临床和两个临床前项目由FASD研究领域的研究人员领导。 2）支持所有NMARC研究人员的科学核心，并作为催化合作和同伴团体指导的论坛。 3）一个行政核心，将为整个NMARC计划提供科学和行政领导，并对中心计划的行政支持和预算监督。行政核心还将负责确保通过招募其他联合国教职员工和新教师雇用，并增强我们的知识传播能力来确保实现中心的目标的进步。对NMARC的进步和成就的评估将是指导委员会的责任，由七个国际知名的FASD科学家组成的外部计划咨询委员会合作，他们将为NMARC的研究活动提供建议和评估，以实现该中心的目标和战略目标。