Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and intervention

胎儿乙醇引起的行为缺陷：机制、诊断和干预

• 批准号: 10674485
• 负责人: Daniel D. Savage
• 金额: $ 148.23万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10674485
• 关键词: Acceleration; Achievement; Address; Advisory Committees; Affect; Alcohols; Area; Award; Behavioral; Biochemical; Biological Markers; Brain Injuries; Child; Cities; Clinical; Clinical Sciences; Communication; Community Outreach; Complement; Development; Diagnosis; Education; Ensure; Environment; Ethanol; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Fetus; Foundations; Goals; Grant; Health Sciences; Individual; International; Intervention; Investigation; Knowledge; Leadership; Life; Mentors; Methods; National Institute on Alcohol Abuse and Alcoholism; New Mexico; Patients; Phase; Philosophy; Physiological; Pilot Projects; Problem behavior; Procedures; Recording of previous events; Research; Research Activity; Research Personnel; Risk; Scientist; Series; Training; Training Programs; Translational Research; Universities; Work; alcohol consumption during pregnancy; alcohol exposure; alcohol research; biobehavior; clinical investigation; diagnostic biomarker; effective intervention; efficacy evaluation; faculty mentor; fetal; graduate student; laboratory experience; meetings; neurobehavioral; neurobiological mechanism; novel; pre-clinical; prenatal; prenatal intervention; prognostic; programs; recruit; symposium; synergism; tool; undergraduate student; web page

PROJECT SUMMARY - OVERALL NMARC is a NIAAA-designated Alcohol Research P50 Center at the UNM Health Sciences Center. The center is comprised of teams of preclinical and clinical scientists with a history of collaborative research interactions whose expertise and contributions have synergized the center’s research environment and is facilitating progress towards the achievement of NMARC’s three strategic objectives. These strategic objectives are to: 1) Advance our understanding of how prenatal alcohol exposure affects basic neurobiological mechanisms resulting in functional brain damage which can lead to life-long adverse neurobehavioral consequences. 2) Develop more effective approaches for the diagnosis of individuals with FASD through the establishment of more sensitive and clinically reliable biochemical, physiological and neurobehavioral biomarkers of alcohol exposure that are detectible early in life, are prognostic of functional brain damage, and could predict long-lasting neurobehavioral consequences in patients with FASD. 3) Develop interventions that are more effective for prenatal alcohol- related behavioral deficits. Better interventions may ultimately require combinations of neurobehavioral, educational and/or pharmacotherapeutic approaches to ameliorate the often subtle, but long-lasting impact of prenatal alcohol-induced behavioral problems. NMARC’s prevailing philosophy is that a research center organized to maximize the coordination, communication and synergistic integration across multiple lines of preclinical and clinical investigation in these three strategic objective areas provides the best long-term prospect of achieving significant progress towards the dual clinical goals of better diagnosis and more effective interventions for patients with FASD. NMARC’s specific aims as an integrated whole during the P50 Phase II will continue to be to: 1) Accelerate progress on each on NMARC’s three strategic objectives. 2) Catalyze the expansion of NMARC’s research capacity and capabilities. 3) Enhance our capability to disseminate knowledge about FASD through seminars, symposia and community outreach activities. 4) Increase the number of undergraduate and graduate students, fellows and residents training in the FASD research field. This P50 competing renewal contains four research components, each consisting of teams of investigators whose projects address one or more of NMARC’s three strategic objectives. Two core components support the center’s research program: 1) A Pilot Project Core with two two-year projects involving faculty investigators new to the FASD research field. 2) An Administrative Core that provides scientific and administrative leadership for the entire NMARC program, along with administrative support and budgetary oversight of all NMARC-related activities. The Administrative Core is also responsible for ensuring progress toward achieving the specific aims of the center as a whole. Assessment of NMARC’s progress towards the achievement of these aims and the strategic objectives is the responsibility of the Executive and Steering Committees working in conjunction with our external Program Advisory Committee comprised of seven internationally renowned FASD scientists.

项目概要 - 总体 NMARC 是 NIAAA 指定的位于新墨西哥州健康科学中心的酒精研究 P50 中心。 由具有合作研究互动历史的临床前和临床科学家团队组成 他们的专业知识和贡献使该中心的研究环境产生了协同效应，并正在促进进展 这些战略目标是： 1) 推进 我们对产前酒精暴露如何影响基本神经生物学机制的理解，导致 功能性脑损伤，可能导致终生不良神经行为后果 2) 发展更多。 通过建立更敏感和更有效的方法来诊断 FASD 个体 临床上可靠的酒精暴露生化、生理和神经行为生物标志物 在生命早期即可检测到，可以预测功能性脑损伤，并可以预测持久的神经行为 3) 制定针对产前饮酒更有效的干预措施。 更好的干预措施最终可能需要结合神经行为、 教育和/或药物治疗方法，以改善通常微妙但持久的影响 NMARC 的普遍理念是，一个研究中心。 组织起来，最大限度地跨多条线进行协调、沟通和协同整合 这三个战略目标领域的临床前和临床研究提供了最佳的长期前景 在实现更好诊断和更有效的双重临床目标方面取得重大进展 P50 II 期期间对 FASD 患者的干预作为一个整体的具体目标。 将继续：1) 加快 NMARC 三个战略目标的进展 2) 促进 扩大 NMARC 的研究能力和能力 3) 增强我们传播知识的能力。 通过研讨会、座谈会和社区外展活动了解 FASD 的情况 4) 增加数量。 FASD 研究领域的本科生和研究生、研究员和住院医师培训。 竞争更新包含四个研究部分，每个部分由研究人员团队组成，其项目 实现 NMARC 的三个战略目标中的一个或多个目标，以支持该中心的两个核心组成部分。 研究计划： 1）一个试点项目核心，包括两个为期两年的项目，涉及刚接触该领域的教师研究人员 2) FASD 研究领域的行政核心，为 FASD 提供科学和行政领导。 整个 NMARC 计划，以及所有 NMARC 相关的行政支持和预算监督 行政核心还负责确保实现具体目标的进展。 评估 NMARC 在实现这些目标和目标方面的进展。 战略目标是执行委员会和指导委员会的职责 我们的外部项目咨询委员会由七位国际知名的 FASD 科学家组成。

项目成果

Covariation Between Brain Function (MEG) and Structure (DTI) Differentiates Adolescents with Fetal Alcohol Spectrum Disorder from Typically Developing Controls.

• DOI: 10.1016/j.neuroscience.2020.09.053
• 发表时间: 2020-11-21
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Pinner JFL;Coffman BA;Stephen JM
• 通讯作者: Stephen JM

Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice.

• DOI: 10.1016/j.toxrep.2014.08.005
• 发表时间: 2014
• 期刊: TOXICOLOGY REPORTS
• 作者: Goggin, Samantha L;Caldwell, Kevin K;Cunningham, Lee Anna;Allan, Andrea M
• 通讯作者: Allan, Andrea M

Effects of exposure to moderate levels of ethanol during prenatal brain development on dendritic length, branching, and spine density in the nucleus accumbens and dorsal striatum of adult rats.

• DOI: 10.1016/j.alcohol.2011.11.008
• 发表时间: 2012-09
• 期刊: Alcohol (Fayetteville, N.Y.)
• 作者: Rice JP;Suggs LE;Lusk AV;Parker MO;Candelaria-Cook FT;Akers KG;Savage DD;Hamilton DA
• 通讯作者: Hamilton DA

Do the anterior and lateral thalamic nuclei make distinct contributions to spatial representation and memory?

• DOI: 10.1016/j.nlm.2016.06.002
• 发表时间: 2016-09-01
• 期刊: NEUROBIOLOGY OF LEARNING AND MEMORY
• 影响因子: 2.7
• 作者: Clark, Benjamin J.;Harvey, Ryan E.
• 通讯作者: Harvey, Ryan E.

Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons.

• DOI: 10.1523/jneurosci.5405-09.2010
• 发表时间: 2010-05-12
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Zucca S;Valenzuela CF
• 通讯作者: Valenzuela CF