H3Africa Kidney Disease Research Network- Collaborative Centers

H3Africa 肾脏疾病研究网络 - 合作中心

基本信息

批准号：
9792262
负责人：
Dwomoa Adu
金额：
$ 75.41万
依托单位：
COLLEGE OF HEALTH SCIENCES, UNIVERSITY OF GHANA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9792262
关键词：
AIDS-Associated Nephropathy Academic Medical Centers Adolescent Advocacy Affect Africa Africa South of the Sahara African Alleles American Apolipoproteins Arizona Award Biomedical Research Biometry Birth Cameroon Caring Certification Child Childhood Chronic Disease Chronic Kidney Failure Clinical Clinical Research Clinical Sciences Clinical and Translational Science Awards Collaborations Communities Comorbidity Competence Country Data Developed Countries Development Disease Doctor of Philosophy Educational workshop End stage renal failure Ensure Etiology Event Extramural Activities Fostering Foundations Functional disorder Funding Genes Genetic Genetic Research Genomics Genotype Ghana Goals Government Agencies Grant HIV Health Health Fairs Health Sciences Histopathology Human Genetics Human Resources Individual Institution Kidney Kidney Diseases Laboratories Laboratory Study Life Cycle Stages Life Expectancy Medical Medical Genetics Modality Modernization Nephrotic Syndrome Nigeria Nursing Research Outcome Participant Patients Physicians Population Prevalence Prevention strategy Prospective cohort study Proteinuria Protocols documentation Public Health Research Research Methodology Research Personnel Research Project Grants Risk Risk Factors Sample Size Scientist Severities Sickle Cell Anemia South Africa Steroid-resistant idiopathic nephrotic syndrome Stroke Tanzania Teaching Hospitals Technology Tenofovir Training Translational Research Treatment Efficacy Tubular formation United States National Institutes of Health Universities Variant Virus Diseases Work acute chest syndrome antiretroviral therapy base career development combat data management epidemiology study ethical legal social implication genetic information high risk improved medical schools nephrotoxicity pediatric patients population based precision medicine prevent risk variant study population support network translational scientist treatment strategy working group young adult

项目摘要

Chronic kidney disease (CKD) including end stage renal disease (CKD stage 5) is a major health problem in sub-Saharan Africa (SSA) affecting more than 50 million individuals but there is lamentable lack of research data and there is no promise of urgently needed preventative strategies. The lack of data on CKD in SSA are in part due to the absence of population-based epidemiologic studies of CKD and a scarcity of physician scientists conducting genetic, clinical and translational research on CKD according to local priorities. Herein, we propose to leverage the H3Africa Kidney Disease Research Network (H3A-KDRN) to (i) conduct genomics, clinical and translational research on the most prevalent forms of CKD; (ii) expand and support a well-trained cadre of African researchers and physician scientists to conduct CKD research according to regional priorities; (iii) engage SSA communities and research participants in the initiation, governance, implementation and dissemination of CKD research and (iv) foster collaboration with U.S.-based basic, clinical and translational researchers (including Africans in the diaspora) to elucidate etiologies and mechanisms and discover effective therapeutic and preventative strategies to combat the extraordinary burden of CKD in people of African ancestry globally The H3A-KDRN is organized as a research consortium initially composed of: (a) 15 academic medical centers/university teaching hospitals in five African countries- Cameroon - 1, Ghana – 4, Nigeria – 8, South Africa - 1 and Tanzania – 1; (b) 9 North American/Israeli research intensive academic medical institutions; (c) 3 shared cores – Training and Career Development, Data Management and Biostatistics and Genotyping Laboratories. At the end of the five-year funding requested in this application, The H3AKDRN will have accomplished the following: 1. Completion of three research projects on: (i) CKD in HIV-infected patients; and (ii) childhood and adolescent onset nephrotic syndrome and (iii) sickle cell disease nephropathy. These three prospective cohort studies will have a total sample size of 5800 participants. 2. Completion of training of four African-based research scientists toward PhD (n=2) and MSc (n=1) in Clinical and Translational Science (CTS) awarded by the University of Arizona 3. Completion of certificate training in clinical research methods for 45 African-based research personnel 4. Establish a high functioning regional Clinical and Translational Research Coordinating Center to support multicenter research in CKD and other non-communicable chronic diseases in SSA. With these foundational objectives, the H3Africa Kidney Disease Research Network will a transformative impact on CKD research in SSA and thence move us closer to the goal of reducing the burden of CKD in the 352 million Africans living in the five H3A-KDRN countries and in the 1.2 billion people of African descent globally.

慢性肾病 (CKD) 包括终末期肾病（CKD 5 期）是一个主要的健康问题撒哈拉以南非洲 (SSA) 影响了超过 5000 万人，但令人遗憾的是缺乏研究数据部分原因是缺乏 SSA 中 CKD 的数据。由于缺乏基于人群的 CKD 流行病学研究以及缺乏医师科学家在此，我们建议根据当地重点开展 CKD 的遗传、临床和转化研究。利用 H3Africa 肾脏疾病研究网络 (H3A-KDRN) 来 (i) 进行基因组学、临床和对最流行的 CKD 形式进行转化研究；(ii) 扩大和支持训练有素的非洲骨干队伍；研究人员和医师科学家根据区域优先事项开展 CKD 研究；(iii) 参与 SSA CKD 的发起、治理、实施和传播中的社区和研究参与者研究以及 (iv) 促进与美国基础、临床和转化研究人员（包括散居海外的非洲人）阐明病因和机制，并发现有效的治疗方法和应对全球非洲裔人群慢性肾病沉重负担的预防策略 H3A-KDRN 是一个研究联盟，最初由以下人员组成： (a) 15 个学术医学五个非洲国家的中心/大学教学医院 - 喀麦隆 - 1 个、加纳 - 4 个、尼日利亚 - 8 个、南非 - 1 个，坦桑尼亚 – 1 个；(b) 9 个北美/以色列研究密集型学术医疗机构；(c) 3 个共享核心——培训和职业发展、数据管理、生物统计学和基因分型实验室。在本申请中请求的五年资助结束时，H3AKDRN 将完成下列的： 1. 完成三个研究项目：(i) 艾滋病毒感染者的慢性肾病；(ii) 儿童和青少年发病性肾病综合征和（iii）镰状细胞病肾病这三项前瞻性队列研究。总样本量为 5800 名参与者。 2. 完成四名非洲研究科学家的临床博士（n=2）和理学硕士（n=1）培训亚利桑那大学授予的转化科学（CTS） 3. 完成45名非洲研究人员临床研究方法证书培训 4. 建立一个高功能的区域临床和转化研究协调中心来支持 SSA CKD 和其他非传染性慢性病的多中心研究。凭借这些基本目标，H3Africa 肾脏疾病研究网络将产生变革性影响 SSA 的 CKD 研究，使我们更接近减轻 3.52 亿人 CKD 负担的目标生活在五个 H3A-KDRN 国家和全球 12 亿非洲人后裔中的非洲人。