Neurophysiologic Correlates of Sensory Over-Responsivity in Tourette Syndrome

抽动秽语综合征感觉过度反应的神经生理学相关性

• 批准号: 10644333
• 负责人: David A Isaacs
• 金额: $ 17.66万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644333
• 关键词: Academic Medical Centers; Accounting; Adolescence; Adolescent; Adult; Affect; Age; Aptitude; Attention deficit hyperactivity disorder; Auditory; Autonomic Dysfunction; Award; Awareness; Behavior; Behavioral; Biological Markers; Child; Childhood; Clinic; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical and Translational Science Awards; Clothing; Data; Development; Development Plans; Diagnosis; Dimensions; Disease; Disease model; Distress; Educational Curriculum; Educational workshop; Electroencephalography; Emotional; Ensure; Environment; Event; Event-Related Potentials; Exhibits; Faculty; Fostering; Frequencies; Functional disorder; Funding; Future; General Population; Gilles de la Tourette syndrome; Goals; Grant; Heart Rate; Heterogeneity; Impairment; Individual; Industry; Institution; International; Investigation; Knowledge; Link; Longevity; Longitudinal Studies; Measurement; Mental disorders; Mentors; Methodology; Mission; Modeling; Monitor; Motor; Movement Disorders; National Institute of Neurological Disorders and Stroke; Nature; Neurobiology; Neurodevelopmental Disorder; Neurology; Noise; Patients; Perception; Pharmaceutical Preparations; Phenotype; Physiological Processes; Population; Practice Guidelines; Principal Investigator; Productivity; Psychophysiology; Quality of life; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Rest; Risk; Risk Marker; Sample Size; Sampling; Scalp structure; School-Age Population; Scientist; Secure; Sensory; Sensory Disorders; Sensory Manifestations; Severities; Signal Transduction; Site; Skin; Stimulus; Symptoms; Tactile; Techniques; Time; Training; Visit; age group; arm; base; candidate identification; candidate marker; career; career development; clinical development; clinical infrastructure; clinical risk; clinically significant; experience; follow-up; functional disability; heart rate variability; improved; indexing; insight; motor symptom; multimodality; neurophysiology; neuropsychiatric symptom; non-motor symptom; novel; patient oriented; premonitory sensory phenomena; professor; psychiatric symptom; recruit; response; sensory gating; sensory input; sensory stimulus; sex; study population; symposium

Project Summary / Abstract Candidate: David Isaacs, MD, MPH is Assistant Professor in the Department of Neurology at Vanderbilt University Medical Center. During his faculty tenure, he has demonstrated enthusiasm and aptitude for patient- centered research, with emphasis on non-motor aspects of movement disorders. Notable early career highlights include founding Vanderbilt’s Adult Tourette Syndrome (TS) Clinic and co-directing Vanderbilt’s Tourette Association of America (TAA) Center of Excellence; securing multiple extra- and intra-mural grants, including the TAA Young Investigator Award to support research into sensory phenomena in TS; and serving as site principal investigator for industry-sponsored clinical trials in TS. He seeks to become a leading researcher in neurophysiologic mechanisms of non-motor symptoms in TS and other movement disorders. Research Project: TS affects 0.5-0.8% of school-aged children, one-third of whom suffer bothersome tics into adulthood. Tics are the defining feature of TS, but sensory symptoms are widespread. In particular, over 50% of children and 80% of adults with TS report sensory over-responsivity (SOR), defined as heightened awareness of and behavioral reactivity to sensory stimuli. SOR is an integral facet of the TS phenotype, but significant knowledge gaps surround its clinical significance and neurobiological underpinnings. This proposal seeks to clarify the mechanistic bases of SOR in TS (Aims 1 and 2) and to determine whether SOR is a risk marker for more severe clinical course in TS (Aim 3). To achieve Aims 1 and 2, Dr. Isaacs will use quantitative electroencephalography (EEG) and multi-modal autonomic measurement to assess neurophysiologic response to auditory and tactile stimuli in adults with TS. To achieve Aim 3, he will use validated rating scales to assess motor, sensory, and psychiatric symptoms in adolescents with TS at two time points: baseline and 2 years. Study results will deepen insight into TS pathophysiology and identify risk markers for more severe TS course. Career Development Plan and Goals: With guidance from his Scientific Steering Committee, Dr. Isaacs has created a curriculum incorporating formal coursework, workshops, conferences, and individualized training with mentors and collaborators to adequately prepare himself for independent research in the neurophysiologic basis of non-motor aspects of movement disorders. His short-term career goals are to develop proficiency in 1) measurement of sensory and neuropsychiatric symptoms; 2) event-related potentials and quantitative EEG methodology; and 3) psychophysiological techniques complementary to EEG. Environment: Vanderbilt University Medical Center is an optimal academic environment for nurturing Dr. Isaacs’ maturation into a fully-fledged independent researcher. The institution has an exceptional track record for fostering productive, independently funded, and internationally renowned clinician-scientists. The primary mission of Vanderbilt’s Clinical and Translational Science Award is provision of infrastructure for clinical research excellence, with an entire arm devoted to training and career development.

项目摘要 /摘要 候选人：MD的David Isaacs，MPH是范德比尔特神经病学系的助理教授 大学医学中心。在任职期间，他表现出对患者的热情和能力 - 集中研究，重点是运动障碍的非运动方面。著名的早期职业 亮点包括成立范德比尔特的成人图雷特综合症（TS）诊所和共同指导范德比尔特的 美国图雷特协会（TAA）卓越中心；获得多个外部和内部赠款， 包括TAA年轻研究者奖，以支持TS中的感官现象研究；和服务 作为TS行业赞助的临床试验的现场主要研究者。他试图成为领导 TS和其他运动障碍中非运动症状的神经生理机制的研究人员。 研究项目：TS影响0.5-0.8％的学龄儿童，其中三分之一遭受了两种混乱 成年。抽动是TS的定义特征，但是感官符号是宽度的。特别是超过50％ 儿童和80％的TS成年人报告感觉过高（SOR），定义为增强 对感觉刺激的意识和行为反应性。 SOR是TS表型的组成部分，但 围绕其临床意义和神经生物学基础的大量知识差距。这个建议 试图阐明TS中SOR的机械基础（目标1和2），并确定SOR是否是风险 在TS中进行更严重的临床课程的标记（AIM 3）。为了实现目标1和2，以撒博士将使用定量 脑电图（EEG）和多模式自主神经测量，以评估神经生理反应 在患有TS的成年人的听觉和触觉刺激上。为了实现目标3，他将使用经过验证的评分量表来评估 TS在两个时间点的青少年中的运动，感觉和精神病症状：基线和2年。 研究结果将加深对TS病理生理学的见解，并确定更严重的TS课程的风险标志物。 职业发展计划和目标：在他的科学指导委员会的指导下，艾萨克斯博士拥有 通过结合了正式课程，讲习班，会议和个性化培训，并与 导师和合作者充分准备自己为神经生理学的独立研究做准备 运动障碍非运动方面的基础。他的短期职业目标是在1中提高熟练程度） 感觉和神经精神症状的测量； 2）与事件相关的电位和定量脑电图 方法论； 3）心理生理技术的完整性。 环境：范德比尔特大学医学中心是培养博士的最佳学术环境。 艾萨克斯（Isaacs）成熟成一个成熟的独立研究人员。该机构具有出色的记录 促进生产性，独立资助和国际知名的临床科学家。主要 范德比尔特的临床和转化科学奖的使命是临床基础设施的规定 卓越的研究，整个手臂都部署在培训和职业发展中。