Neurophysiologic Correlates of Sensory Over-Responsivity in Tourette Syndrome

抽动秽语综合征感觉过度反应的神经生理学相关性

• 批准号: 10644333
• 负责人: David A Isaacs
• 金额: $ 17.66万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644333
• 关键词: Academic Medical Centers; Accounting; Adolescence; Adolescent; Adult; Affect; Age; Aptitude; Attention deficit hyperactivity disorder; Auditory; Autonomic Dysfunction; Award; Awareness; Behavior; Behavioral; Biological Markers; Child; Childhood; Clinic; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical and Translational Science Awards; Clothing; Data; Development; Development Plans; Diagnosis; Dimensions; Disease; Disease model; Distress; Educational Curriculum; Educational workshop; Electroencephalography; Emotional; Ensure; Environment; Event; Event-Related Potentials; Exhibits; Faculty; Fostering; Frequencies; Functional disorder; Funding; Future; General Population; Gilles de la Tourette syndrome; Goals; Grant; Heart Rate; Heterogeneity; Impairment; Individual; Industry; Institution; International; Investigation; Knowledge; Link; Longevity; Longitudinal Studies; Measurement; Mental disorders; Mentors; Methodology; Mission; Modeling; Monitor; Motor; Movement Disorders; National Institute of Neurological Disorders and Stroke; Nature; Neurobiology; Neurodevelopmental Disorder; Neurology; Noise; Patients; Perception; Pharmaceutical Preparations; Phenotype; Physiological Processes; Population; Practice Guidelines; Principal Investigator; Productivity; Psychophysiology; Quality of life; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Rest; Risk; Risk Marker; Sample Size; Sampling; Scalp structure; School-Age Population; Scientist; Secure; Sensory; Sensory Disorders; Sensory Manifestations; Severities; Signal Transduction; Site; Skin; Stimulus; Symptoms; Tactile; Techniques; Time; Training; Visit; age group; arm; base; candidate identification; candidate marker; career; career development; clinical development; clinical infrastructure; clinical risk; clinically significant; experience; follow-up; functional disability; heart rate variability; improved; indexing; insight; motor symptom; multimodality; neurophysiology; neuropsychiatric symptom; non-motor symptom; novel; patient oriented; premonitory sensory phenomena; professor; psychiatric symptom; recruit; response; sensory gating; sensory input; sensory stimulus; sex; study population; symposium

Project Summary / Abstract Candidate: David Isaacs, MD, MPH is Assistant Professor in the Department of Neurology at Vanderbilt University Medical Center. During his faculty tenure, he has demonstrated enthusiasm and aptitude for patient- centered research, with emphasis on non-motor aspects of movement disorders. Notable early career highlights include founding Vanderbilt’s Adult Tourette Syndrome (TS) Clinic and co-directing Vanderbilt’s Tourette Association of America (TAA) Center of Excellence; securing multiple extra- and intra-mural grants, including the TAA Young Investigator Award to support research into sensory phenomena in TS; and serving as site principal investigator for industry-sponsored clinical trials in TS. He seeks to become a leading researcher in neurophysiologic mechanisms of non-motor symptoms in TS and other movement disorders. Research Project: TS affects 0.5-0.8% of school-aged children, one-third of whom suffer bothersome tics into adulthood. Tics are the defining feature of TS, but sensory symptoms are widespread. In particular, over 50% of children and 80% of adults with TS report sensory over-responsivity (SOR), defined as heightened awareness of and behavioral reactivity to sensory stimuli. SOR is an integral facet of the TS phenotype, but significant knowledge gaps surround its clinical significance and neurobiological underpinnings. This proposal seeks to clarify the mechanistic bases of SOR in TS (Aims 1 and 2) and to determine whether SOR is a risk marker for more severe clinical course in TS (Aim 3). To achieve Aims 1 and 2, Dr. Isaacs will use quantitative electroencephalography (EEG) and multi-modal autonomic measurement to assess neurophysiologic response to auditory and tactile stimuli in adults with TS. To achieve Aim 3, he will use validated rating scales to assess motor, sensory, and psychiatric symptoms in adolescents with TS at two time points: baseline and 2 years. Study results will deepen insight into TS pathophysiology and identify risk markers for more severe TS course. Career Development Plan and Goals: With guidance from his Scientific Steering Committee, Dr. Isaacs has created a curriculum incorporating formal coursework, workshops, conferences, and individualized training with mentors and collaborators to adequately prepare himself for independent research in the neurophysiologic basis of non-motor aspects of movement disorders. His short-term career goals are to develop proficiency in 1) measurement of sensory and neuropsychiatric symptoms; 2) event-related potentials and quantitative EEG methodology; and 3) psychophysiological techniques complementary to EEG. Environment: Vanderbilt University Medical Center is an optimal academic environment for nurturing Dr. Isaacs’ maturation into a fully-fledged independent researcher. The institution has an exceptional track record for fostering productive, independently funded, and internationally renowned clinician-scientists. The primary mission of Vanderbilt’s Clinical and Translational Science Award is provision of infrastructure for clinical research excellence, with an entire arm devoted to training and career development.

项目概要/摘要 候选人：David Isaacs，医学博士、公共卫生硕士，范德堡大学神经病学系助理教授 在大学医学中心任教期间，他表现出了对患者的热情和能力。 以研究为中心，重点关注运动障碍的非运动方面。 亮点包括创立范德比尔特成人图雷特综合症 (TS) 诊所并共同指导范德比尔特 美国图雷特协会 (TAA) 卓越中心；获得多项校外和校内资助， 包括 TAA 青年研究者奖，以支持对 TS 和服务中感官现象的研究； 作为行业资助的 TS 临床试验的现场首席研究员，他致力于成为领先的研究人员。 TS 和其他运动障碍非运动症状的神经生理学机制的研究员。 研究项目： TS 影响 0.5-0.8% 的学龄儿童，其中三分之一患有令人烦恼的抽动症 抽动是 TS 的典型特征，但感觉症状尤其普遍，超过 50%。 的儿童和 80% 患有 TS 的成人报告感觉过度反应 (SOR)，定义为气球 对感觉刺激的意识和行为反应是 TS 表型的一个组成部分。 该提议的临床意义和神经生物学基础存在重大知识差距。 寻求澄清 TS 中 SOR 的机制基础（目标 1 和 2）并确定 SOR 是否存在风险 TS 更严重临床病程的标记（目标 3） 为了实现目标 1 和 2，Isaacs 博士将使用定量方法。 脑电图 (EEG) 和多模式自主测量来评估神经生理反应 为了实现目标 3，他将使用经过验证的评定量表来评估 TS 成人的听觉和触觉刺激。 患有 TS 的青少年在两个时间点的运动、感觉和精神症状：基线和 2 年。 研究结果将加深对 TS 病理生理学的了解，并确定更严重 TS 病程的风险标记。 职业发展计划和目标：在科学指导委员会的指导下，艾萨克斯博士 创建了一个包含正式课程、研讨会、会议和个性化培训的课程 导师和合作者为神经生理学的独立研究做好充分准备 他的短期职业目标是提高以下方面的能力：1) 感觉和神经精神症状的测量；2）事件相关电位和定量脑电图 方法；3）与脑电图互补的心理生理学技术。 环境：范德比尔特大学医学中心是培养范德比尔特博士的最佳学术环境。 艾萨克斯成长为一名成熟的独立研究员，该机构拥有卓越的记录。 旨在培养富有成效、独立资助且国际知名的临床医生科学家。 范德比尔特临床和转化科学奖的使命是为临床提供基础设施 卓越的研究，整个部门致力于培训和职业发展。