Cancer Center Core Support Grant

癌症中心核心支持补助金

• 批准号: 8018789
• 负责人: H. Shelton Earp
• 金额: $ 684万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8018789
• 关键词: Cancer; Center; Core; Support; Grant

DESCRIPTION (provided by applicant): The UNC Lineberger Comprehensive Cancer Center requests renewal of its National Cancer Institute (NCI) Center Core Support Grant (CCSG) for Years 36-40. Over the past CCSG cycle, the Center has grown in funding, membership, facilities and productivity. NCI funding has increased from $45M to $64M and total cancer-related extramural funding rose from $150M to $220M yearly. The Center's 295 members (up from 235) span the basic, clinical and population sciences; all areas have seen an increase in faculty funding and research productivity. A tradition of interaction among disciplines, fostered by a proactive matrix cancer center at a highly-regarded public university provides an outstanding venue for integrating forward-looking interdisciplinary cancer research. Cancer center members hold 34 multi-investigator program grants and 26 training grants. Faculty additions in the physical and pharmaceutical sciences created new opportunities in drug discovery and delivery. Substantial investment in faculty, equipment and bioinformatics dramatically expanded our cancer genetics research effort; UNC was again selected as a site of The Cancer Genome Atlas. Thirty-eight clinical researchers were recruited, strengthening our multidisciplinary cancer care and research teams. Our publication rate in top clinical oncology journals increased by four-fold. Accruals to therapeutic trials, including investigator-initiated trials, more than doubled to 850 and 434 respectively. Our population scientists initiated new endeavors in cancer communication, dissemination, survivorship, and molecular epidemiology. Groundbreaking observations in breast cancer minority disparity research have emerged from the Center's epidemiology and clinical programs. The formation of transdisciplinary teams stimulates progress toward implementing the Center's and NCI's strategic objectives. Major events include opening the North Carolina Cancer Hospital, a new clinical structure that nearly triples patient care space, and new basic science buildings. The Center's significant and continued expansion, including 20 faculty recruitments now in progress, is driven by remarkable institutional support including direct support for cancer research from the state legislature. The UNC Lineberger requests funding for nine scientific programs, 20 shared resources, two staff investigators, and for leadership, planning and evaluation, administration, and developmental research. The increased CCSG budget will support technological and operational expansion of cores and faculty recruitment in the basic, translational, clinical, and population sciences. With these funds, a talented faculty integrated through cancer center mechanisms will make advances in the prevention, early detection, and treatment of cancer in North Carolina and the nation.

描述（由申请人提供）：UNC Lineberger综合癌症中心要求其国家癌症研究所（NCI）中心核心支持补助金（CCSG）续约36 - 40年。在过去的CCSG周期中，该中心在资金，会员资格，设施和生产力方面发展。 NCI资金从4500万美元增加到6400万美元，与癌症相关的校外资金每年增长到1.5亿美元增加到2.2亿美元。该中心的295名成员（从235名提高）涵盖了基础，临床和人口科学；所有领域的教师资金和研究生产力都在提高。在备受赞誉的公立大学的一个积极主动的基质癌症中心培养的学科之间相互作用的传统为整合前瞻性跨学科癌症研究提供了一个杰出的场所。癌症中心成员持有34个多侵袭者计划补助金和26个培训补助金。物理和药学的教师增加为药物发现和分娩创造了新的机会。对教师，设备和生物信息学的大量投资大大扩大了我们的癌症遗传学研究工作； UNC再次被选为癌症基因组地图集的部位。招募了38名临床研究人员，从而加强了我们的多学科癌症护理和研究团队。我们在顶级临床肿瘤学期刊上的发表率增加了四倍。应计对治疗试验的应计，包括研究人员发起的试验，分别翻了一番，达到850和434。我们的人口科学家在癌症传播，传播，生存和分子流行病学方面发起了新的努力。该中心的流行病学和临床计划中出现了乳腺癌少数差异研究的突破性观察。跨学科团队的成立刺激了实施中心和NCI的战略目标的进步。 重大事件包括开设北卡罗来纳州癌症医院，新的临床结构几乎是患者护理空间的三倍，以及新的基础科学建筑。该中心的重大和持续扩张，包括目前正在进行的20名教职员工，这是由机构支持的显着支持所驱动的，包括直接支持州立法机关的癌症研究。 UNC Lineberger要求为九个科学计划，20个共享资源，两名员工调查人员以及领导，计划和评估，管理和发展研究提供资金。 CCSG预算的增加将支持基础，转化，临床和人口科学的核心和教师招聘的技术和运营扩展。借助这些资金，通过癌症中心机制融入的才华横溢的教师将在北卡罗来纳州和国家对癌症的预防，早期发现和治疗方面取得进步。