Ohio State Neuroscience Center Core

俄亥俄州立神经科学中心核心

• 批准号: 8211341
• 负责人: DANA M MCTIGUE
• 金额: $ 10.78万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8211341
• 关键词: Animal Model; Award; Behavior; Behavioral; Behavioral Paradigm; Contusions; Devices; Funding; Genetic; Injury; Knockout Mice; Laboratories; Microinjections; Modeling; National Institute of Neurological Disorders and Stroke; Neurosciences; Ohio; Operative Surgical Procedures; Paper; Peripheral nerve injury; Rattus; Research; Research Personnel; Rodent; Rodent Model; Running; Services; Spinal; Spinal cord injury; Techniques; Testing; Therapeutic Agents; Toxin; Training; Training Programs; Transgenic Animals; Transgenic Mice; Wages; Work; animal care; behavior measurement; behavior test; behavioral impairment; efficacy testing; experience; mouse model; nerve injury; novel; research facility; response; tool

This Core has two related components that offer different services. The CNS/PNS Injury Core will provide technical support to generate animal models of Injury and to characterize their behavioral impairment after injury. The Rodent Behavior Core will provide services to test rodent models in standard behavioral paradigms. This Core component also synergizes with the Genetics Core and provides a mechanism to analyze the behavior of transgenic and knockout mice. I. CNS/PSN Nerve Injury Core Overview The study of CNS/PNS nerve Injury is a major strength on the OSU campus. With the services available in this Core, NINDS funded investigators will be able to greatly expand the scope of their work by having easy access to an array of surgical and behavioral techniques which are not typically located together in a single laboratory. This Core will also provide the ability to test novel agents in CNS/PNS Injury models. During the current award nine Pis used this Core resulting in sixteen papers and one new R01.

该核心有两个相关的组件提供不同的服务。中枢神经系统/PNS损伤核心将提供技术支持，以产生损伤动物模型，并在伤害后表征其行为障碍。啮齿动物行为核心将为标准行为范式中的啮齿动物模型提供服务。 该核心成分还与遗传学核心协同，并提供了分析转基因和基因敲除小鼠行为的机制。 I. CNS/PSN神经损伤核心 概述 CNS/PNS神经损伤的研究是OSU校园的主要优势。借助此核心中可用的服务，NINDS资助的研究人员将能够轻松访问一系列通常不在一个实验室中的外科手术和行为技术来大大扩大其工作范围。 该核心还将提供测试中枢神经系统/PNS损伤模型中新型药物的能力。 在当前奖励期间，九个PI使用了这一核心，从而产生了16篇论文和一份新的R01。