Sleep-Wake Cycles of Individuals with Inflammatory Bowel Disease

炎症性肠病患者的睡眠-觉醒周期

• 批准号: 10604701
• 负责人: Linda Yoo
• 金额: $ 4.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-16 至 2025-09-15
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10604701
• 关键词: Abdominal Pain; Address; Adult; Adverse effects; American; Animal Model; Animals; Arousal; Award; Behavior; Behavior Therapy; Biologic Characteristic; Biological; Biological Markers; Characteristics; Chronic; Circadian Dysregulation; Circadian Rhythms; Clinic; Constipation; Crohn' s disease; Data; Development; Diarrhea; Disease; Disease Outcome; Disease remission; Electronics; Environment; Family; Fatigue; Fellowship; Financial Hardship; Functional disorder; Gases; Gastroenterology; Gastrointestinal Diseases; Genetic; Goals; Health; Healthcare; Hospitalization; Hour; Human; Individual; Individual National Research Service Award; Inflammatory; Inflammatory Bowel Diseases; Intervention; Interview; Intestines; Investigation; Jet Lag Syndrome; Knowledge; Lead; Leukocyte L1 Antigen Complex; Life; Life Style; Link; Measurement; Measures; Medical center; Metabolic; Methods; Minority; Modeling; Nausea; Nursing Research; Outcome; Participant; Patients; Persons; Pittsburgh Sleep Quality Index; Population; Prevalence; Principal Investigator; Productivity; Progressive Disease; Qualitative Methods; Quality of life; Questionnaires; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Rest; Risk; Role; Sampling; Schedule; Schools; Self Management; Sleep; Sleep Disorders; Sleep Fragmentations; Sleep Wake Cycle; Sleep disturbances; Societal Factors; Structure; Symptoms; System; Testing; Time; Training; Ulcerative Colitis; United States; Universities; Washington; Work; Wrist; actigraphy; behavior influence; care costs; chronic autoimmune disease; circadian pacemaker; design; diaries; doctoral student; dysbiosis; experience; gastrointestinal symptom; gastrointestinal system; gut dysbiosis; improved; insight; intestinal barrier; lens; minority patient; mortality; pre-doctoral; programs; prospective; recruit; skills; sleep quality; social; social factors; social health determinants; stool sample; symptom science

PROJECT SUMMARY The purpose of this Ruth L. Kirschstein National Research Service Award (NRSA) Individual Pre-Doctoral Fellowship in Nursing Research (F31) application is to provide research training for Ms. Yoo, a beginning second-year doctoral student at the University of Washington (UW). The long-term goal of this training is for Ms. Yoo to develop into an independent researcher at a research-intensive academic setting with a program of research focused on improving health outcomes of persons with inflammatory bowel disease (IBD) through the development of self-management strategies that address biological and socio-ecological factors. The costs of care and prevalence of IBD, a chronic gastrointestinal (GI) disease, have been rising in the United States. IBD symptoms (e.g., diarrhea, abdominal pain) negatively impact quality of life, work productivity, and school attendance; thus, there is a clear need to explore behavior modifications (e.g., behavior-influenced sleep-wake cycles) to mitigate the symptoms of those with IBD. Although animal models have shown the adverse effects of disrupted sleep-wake cycles on the GI system (e.g., intestinal dysbiosis), there is little research that focuses on the impact of inconsistent sleep-wake cycles on IBD health outcomes as well role of external socio-ecological factors (e.g., work and family obligations) on sleep-wake cycles of those with IBD. The aims of the proposed study that employ both quantitative and qualitative methods are to understand the relationship between rest- activity rhythm (RAR) characteristics and social jetlag with fatigue, sleep quality, GI symptoms, and disease activity, and identify the social and societal factors that impact sleep-wake cycles. Unlike most IBD sleep studies, this study will use objective actigraphy to measure RARs and social jetlag, and a qualitative portion will provide additional insight from IBD participants on socio-ecological factors that impact sleep-wake cycles which quantitative measures cannot fully capture. The socio-ecological model of health and sleep will guide the research project to consider the societal, social, and individual level impacts of sleep-wake cycles on IBD outcomes. The principal investigator will collect prospective data on 24 IBD participants from the University of Washington Medical Center's gastroenterology clinic and leverage existing data on 26 IBD participants from a previous study focused on nighttime sleep outcomes, resulting in a total of 50 participants. This award will prepare a pre-doctoral trainee through advanced coursework and direct research experience, qualitative and quantitative methods, focused analysis of RARs, and discovery of the relationships among three different concepts related to sleep-wake cycles and IBD-related health outcomes. The findings generated from this investigation will provide foundational knowledge for building a new program of research in self-management and symptom science in IBD.

项目摘要 这个露丝·柯希斯坦国家研究服务奖（NRSA）的目的 护理研究奖学金（F31）申请是为Yoo女士提供研究培训，这是一个开始 华盛顿大学（UW）的二年级博士生。这项培训的长期目标是 Yoo女士将在研究密集型学术环境中发展成一个独立研究人员 研究重点是改善通过炎症性肠病（IBD）的健康结果 制定解决生物学和社会生态因素的自我管理策略。费用 慢性胃肠道（GI）疾病IBD的护理和患病率在美国一直在上升。 IBD 症状（例如腹泻，腹痛）对生活质量，工作生产力和学校产生负面影响 出勤；因此，显然需要探索行为修改（例如，受行为影响的睡眠效益 循环）减轻IBD患者的症状。尽管动物模型显示了 胃肠道系统上的破坏睡眠唤醒周期（例如，肠道营养不良），很少有研究重点是 不一致的睡眠效果周期对IBD健康结果的影响以及外部社会生态学的作用 IBD患者的睡眠效果周期的因素（例如，工作和家庭义务）。提议的目的 采用定量和定性方法的研究是了解休息之间的关系 活动节奏（RAR）特征和社交喷气lag，疲劳，睡眠质量，胃肠道症状和疾病 活动，并确定影响睡眠效果周期的社会和社会因素。与大多数IBD睡眠不同 研究，本研究将使用客观的行为来衡量RARS和社会喷气lag，定性部分将 提供IBD参与者对影响睡眠效果周期的社会生态因素的其他见解 定量措施无法完全捕获。健康和睡眠的社会生态模型将指导 研究项目是为了考虑睡眠效果周期对IBD的社会，社会和个人水平的影响 结果。首席调查员将收集有关24位IBD参与者的预期数据 华盛顿医学中心的胃肠病学诊所，并利用26名IBD参与者的现有数据 先前的研究重点是夜间睡眠结果，总共有50名参与者。这个奖项将 通过高级课程和直接研究经验，定性和 定量方法，重点分析RARS以及发现三种不同的关系 与睡眠效果周期和与IBD相关的健康结果有关的概念。从此产生的发现 调查将为建立新的自我管理研究计划提供基本知识 和IBD的症状科学。