Optical Imaging of Tactile Information in S1 Cortex

S1 皮层触觉信息的光学成像

• 批准号: 8318782
• 负责人: Robert Mark Friedman
• 金额: $ 41.55万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318782
• 关键词: Address; Area; Attention; Behavior; Behavioral; Brain; Code; Complement; Complex; Cues; Data; Development; Digit structure; Discrimination; Dyes; Exhibits; Feedback; Functional Magnetic Resonance Imaging; Goals; Hand; Health; Image; Length; Location; Maps; Mechanoreceptors; Methods; Monkeys; Motion; Motion Perception; Movement; Nature; Neurons; Parietal; Perception; Prosthesis; Psychophysiology; Recovery of Function; Resolution; Role; Signal Transduction; Skin; Somatosensory Cortex; Stimulus; Stroke; Structure; Surface; Tactile; Texture; Visual system structure; awake; clinically relevant; human subject; imaging modality; neural circuit; object motion; object shape; optical imaging; receptor; research study; response; spatiotemporal; ventral intraparietal area; voltage

Description (provided by applicant): The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain. Responses within different areas of primary somatosensory cortex (SI) will be examined (areas 3a, 3b, 1, and 2). Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain, in particular in the primary somatosensory cortex (SI). These studies will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics.

描述（由申请人提供）：该提案的目的是研究大脑如何编码大脑中的触觉运动信息。将检查原发性体感皮质（SI）不同区域内的反应（3A，3B，1和2区域）。了解其功能角色的核心是找出一个区别于另一个领域的原因。通过使用简单的和复杂的刺激，我们旨在区分其响应与刺激的物理性质紧密相关的区域以及其反应不变并更紧密地反映运动感知的区域。我们将采用光学成像，电压敏感的染料成像，大胆的fMRI，单个单元记录和解剖跟踪方法来解决这些问题。这些实验将阐明触觉行为和注意力的神经循环系统，这将与触觉和触觉假体的发展相关。公共卫生相关性：该提案的目的是研究大脑如何编码大脑中的触觉运动信息，尤其是在主要体感皮质（SI）中。这些研究将阐明触觉行为和注意力的神经电路，理解这将与触觉和触觉假体发展功能的恢复具有临床意义。