Neural basis of tactile object perception in SI cortex

SI 皮层触觉物体感知的神经基础

• 批准号: 9078506
• 负责人: Robert Mark Friedman
• 金额: $ 61.39万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9078506
• 关键词: Animals; Area; Behavior; Behavioral; Binding; Brain; Code; Cortical Column; Data; Data Set; Development; Digit structure; Discrimination; Electrophysiology (science); Environment; Esthesia; Exhibits; Failure; Fingers; Food; Functional Magnetic Resonance Imaging; Future; Goals; Hand; Image; Investigation; Knowledge; Lasers; Lead; Lifting; Link; Location; Manuals; Maps; Measurable; Methods; Modality; Monkeys; Motion; Motor; Neurons; Optics; Pattern; Physiologic pulse; Positioning Attribute; Posture; Primary Lesion; Primates; Process; Prosthesis; Resolution; Role; Sensory; Shapes; Somatosensory Cortex; Specificity; Staging; Surface; Tactile; Techniques; Testing; Texture; Visual system structure; Weight; Weight Perception; awake; base; body language; brain machine interface; clinically relevant; design; grasp; information processing; neural circuit; nonhuman primate; novel; object perception; optical imaging; optogenetics; public health relevance; relating to nervous system; sensory integration; somatosensory; tool

 DESCRIPTION (provided by applicant): The goal of this proposal is to investigate the organization and circuitry within the hand and digit region of primary somatosensory cortex in nonhuman primates. Hand and digit behavior are defining aspects of object identification in primate behavior, and are central to different types of tool use, typing, texting, and body language. Despite this, little is known regarding the cortical circuitry underlying different stage of sensory (tactile and proprioceptive) processing. This proposal will use multiple anatomical and functional approaches to discover the intra-areal and inter-areal connectivity patterns between functional columns in the hand representation of primary somatosensory areas (3a, 3b, 1, and 2). These approaches will include anatomical tract tracing and functional tract tracing (using optical imaging and fMRI during focal electrical and pulsed near infrared laser stimulation). The role of these circuits during behavior will be examined. These studies will provide invaluable data for incorporation of sensory guidance in manual motor prosthetics, an area in which there is currently little understanding.

 描述（由适用提供）：该提案的目的是调查非人类隐私中主要体感皮质的手和数字区域内的组织和电路。手和数字行为定义了灵长类动物行为中对象识别的各个方面，并且是不同类型的工具使用，打字，发短信和肢体语言的核心。尽管如此，关于感官（触觉和本体感受）处理的不同阶段的皮质回路，知之甚少。该建议将使用多种解剖学和功能性方法来发现主要体感区域（3A，3B，1和2）手动表示功能柱之间的弧内和截肢间连接模式。这些方法将包括解剖区跟踪和功能性痕迹跟踪（在焦点电气和脉冲近红外激光刺激期间使用光学成像和fMRI）。这些电路在行为中的作用将进行检查。这些研究将为手动运动假肢中的保险指导提供宝贵的数据，目前几乎没有理解的领域。