NEURAL SUBSTRATES OF AGE-RELATED COGNITIVE DECLINE IN MONKEYS

猴子与年龄相关的认知衰退的神经基础

• 批准号: 7958321
• 负责人: Douglas L Rosene
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958321
• 关键词: 15 year old; 20 year old; Age; Age-associated memory impairment; Aging; Behavior assessment; Biological Preservation; Blood specimen; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Data; Female; Funding; Goals; Grant; Human; Impaired cognition; Inflammation; Institution; MRI Scans; Macaca mulatta; Modeling; Monkeys; Neurons; New England; Primates; Research; Research Personnel; Resources; Sampling; Source; Testing; Therapeutic Intervention; Tissue Sample; United States National Institutes of Health; base; brain tissue; design; middle age; relating to nervous system; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The rhesus monkey is a model of normal human aging that allows cognitive testing to be followed by optimal preservation of brain tissue for study. This projects tests the hypothesis that age-related cognitive decline results from a cascade of mild degenerative changes beginning with inflammation in white matter followed by functional and then structural changes in neurons. This is a longitudinal project that follows a group of 12 middle aged female rhesus monkeys for five years beginning between 13 and 15 years of age. Regular behavioral assessment is conducted to identify the rate of age-related cognitive decline and to determine how this differs among subjects in order to differentiate between monkeys that age "successfully" and those that are relatively "unsuccessful". Regular MRI scans, blood samples and CSF samples are collected to assess different markers of aging. At the end of five years the brain tissue samples will be used to identify changes responsible for cognitive decline. As the degree of cognitive impairment is mild at 13 - 15 but high by 18 - 20 years of age, these data will allow us to identify brain changes associated with the rate of cognitive decline with the goal of designing therapeutic interventions aimed as slowing or reversing cognitive decline.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 恒河猴是正常人类衰老的模型，可以使认知测试之后是对脑组织的最佳保存。该项目检验了以下假设：与年龄相关的认知下降是由一系列温和的退化性变化引起的，从白质的炎症开始，随后是功能性，然后是神经元的结构变化。这是一个纵向项目，遵循13至15岁的12年中的12个中年女性恒河猴组成的小组。进行定期的行为评估以确定与年龄相关的认知下降速度，并确定受试者之间的不同之处，以区分“成功年龄”和相对“失败”的猴子。常规MRI扫描，血液样本和CSF样品被收集以评估不同的衰老标记。在五年结束时，脑组织样品将用于确定导致认知能力下降的变化。由于认知障碍的程度在13-15时轻度，但在18-20岁时高，这些数据将使我们能够确定与认知下降率相关的大脑变化，目的是设计治疗干预措施，旨在减慢或反向认知能力下降。