NEURAL SUBSTRATES OF AGE-RELATED COGNITIVE DECLINE IN MONKEYS

猴子与年龄相关的认知衰退的神经基础

• 批准号: 8357922
• 负责人: Douglas L Rosene
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357922
• 关键词: 15 year old; 20 year old; Age; Age-associated memory impairment; Aging; Behavior assessment; Biological Preservation; Blood specimen; Brain; Cognitive; Data; Female; Funding; Goals; Grant; Human; Impaired cognition; Inflammation; MRI Scans; Macaca mulatta; Modeling; Monkeys; National Center for Research Resources; Neurons; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Testing; Therapeutic Intervention; Tissue Sample; United States National Institutes of Health; base; brain tissue; cost; design; middle age; relating to nervous system; white matter; 15 year old; 20 year old; Age; Age-associated memory impairment; Aging; Behavior assessment; Biological Preservation; Blood specimen; Brain; Cognitive; Data; Female; Funding; Goals; Grant; Human; Impaired cognition; Inflammation; MRI Scans; Macaca mulatta; Modeling; Monkeys; National Center for Research Resources; Neurons; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Testing; Therapeutic Intervention; Tissue Sample; United States National Institutes of Health; base; brain tissue; cost; design; middle age; relating to nervous system; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Neural Substrates of Age-related Cognitive Decline in Monkeys The rhesus monkey is a model of normal human aging that allows cognitive testing to be followed by optimal preservation of brain tissue for study. This projects tests the hypothesis that age-related cognitive decline results from a cascade of mild degenerative changes beginning with inflammation in white matter followed by functional and then structural changes in neurons. This is a longitudinal project that follows a group of 12 middle aged female rhesus monkeys for five years beginning between 13 and 15 years of age. Regular behavioral assessment is conducted to identify the rate of age-related cognitive decline and to determine how this differs among subjects in order to differentiate between monkeys that age "successfully" and those that are relatively "unsuccessful". Regular MRI scans, blood samples and CSF samples are collected to assess different markers of aging. At the end of five years the brain tissue samples will be used to identify changes responsible for cognitive decline. As the degree of cognitive impairment is mild at 13 - 15 but high by 18 - 20 years of age, these data will allow us to identify brain changes associated with the rate of cognitive decline with the goal of designing therapeutic interventions aimed at slowing or reversing cognitive decline.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 猴子与年龄相关的认知下降的神经底物 恒河猴是正常人类衰老的模型，可以使认知测试之后是对脑组织的最佳保存。该项目检验了以下假设：与年龄相关的认知下降是由一系列温和的退化性变化引起的，从白质的炎症开始，随后是功能性，然后是神经元的结构变化。这是一个纵向项目，遵循13至15岁的12年中的12个中年女性恒河猴组成的小组。进行定期的行为评估以确定与年龄相关的认知下降速度，并确定受试者之间的不同之处，以区分“成功年龄”和相对“失败”的猴子。常规MRI扫描，血液样本和CSF样品被收集以评估不同的衰老标记。在五年结束时，脑组织样品将用于确定导致认知能力下降的变化。由于认知障碍的程度为13-15，但在18-20岁时高，这些数据将使我们能够确定与认知能力下降率相关的大脑变化，目的是设计旨在减慢或逆转认知能力下降的治疗干预措施。