Developmental and peer effects on the neurobiology of cognitive control and reward processes

认知控制和奖励过程的神经生物学的发展和同伴效应

基本信息

批准号：
10204863
负责人：
BRIAN M HICKS
金额：
$ 49.4万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204863
关键词：
12 year old 15 year old 18 year old 20 year old Adolescence Adolescent Adult Affect Affective Age Alcohol abuse Alcohol consumption Alcohols Behavioral Brain Clinic Coitus Consumption Cues Data Development Drug usage Ensure Exhibits Feedback Functional Magnetic Resonance Imaging Impairment Intake Joints Lead Lifestyle-related condition Link Longitudinal Studies Longitudinal cohort Measures Mental Health Modeling Motivation Neurobiology Neurologic Process Patients Pattern Pharmaceutical Preparations Process Protocols documentation Psychiatry Psychopathology Research Rewards Risk Risk-Taking Role Sampling Shapes Signal Transduction Social Interaction Stimulus Time adolescent alcohol risk adolescent substance use alcohol risk base cognitive control cohort comorbidity design deviant peer drug use behavior early alcohol use early onset substance use emerging adult financial incentive follow up assessment functional MRI scan high reward high risk longitudinal design network models neurobehavioral neurophysiology peer peer influence preadolescence psychosocial recruit relating to nervous system reward anticipation social substance use underage drinking young adult

项目摘要

Abstract Alcohol and drug use problems that onset in adolescence are associated with a more severe and persistent course and impairments in multiple domains of psychosocial functioning. A key predictor of loss of control of substance use is the difference in activation between the reward and cognitive control networks. Specifically, the greater the activation of the reward network to drug cues relative to that of the control network, the less control over drug use behavior. During adolescence, maturation of the reward network outpaces that of the control network, resulting in a bias toward risk-taking when in the presence of reward cues. In adolescents but not adults, the presence of peers has been shown to increase risk-taking due to greater activation of the reward network. Adolescents spend more time with peers than adults and deviant peer affiliation is the strongest correlate of alcohol and drug use problems, and drinking alcohol is an especially social activity shared with peers. The combination of these neurodevelopmental and peer influences on the reward network then may be key neurobiological and contextual mechanisms that account for the large increases in alcohol and drug use problems during adolescence. We will examine the development of the neurobiological processes of the reward and cognitive control networks, peer effects on these networks, and how these neurobiological and contextual processes contribute to risk-taking and alcohol and drug use problems in adolescence using a longitudinal fMRI study. We will use an accelerated longitudinal cohort design that covers pre- (10-12 years-old), middle (13-15 years-old), and later (16-18 years-old) adolescence (total N=210), with 1-year and 2-year follow-up assessments. This design will allow us to cover 10 years (10 to 20 years-old) of neurobiological development in half the time. Our protocol will include an assessment of peer presence on reward activation during risking-taking (stoplight task) and reward anticipation and receipt (monetary incentive delay); neurological processes associated with explicit social feedback in the form of acceptance and rejection (chatroom social interaction task); and a basic cognitive control task (stop signal) to assess inhibitory processes. We predict that peer presence will increase reward activation during risk taking and reward receipt, and that these peer effects on reward activation will increase from pre- to middle adolescence. Further, greater reward reactivity and weaker cognitive control will be associated with greater sensitivity to peer influences. Finally, greater reward reactivity, weaker cognitive control, and greater sensitivity to both peer presence and explicit social feedback will be associated with greater alcohol and drug use problems and comorbid externalizing and internalizing problems.

抽象的青春期发作的酒精和药物使用问题与更严重和更严重有关心理社会功能多个领域的持续课程和障碍。损失的关键预测指标对物质使用的控制是奖励和认知控制网络之间激活的差异。具体而言，相对于控制网络的奖励网络对药物提示的激活越大，对吸毒行为的控制较少。在青春期，奖励网络的成熟超过在控制网络的情况下，在存在奖励提示的情况下会产生偏见。在青少年但不是成年人，同伴的存在已被证明会增加冒险激活奖励网络。青少年在同龄人和成年人和异常同龄人的时间里花费更多的时间隶属关系是酒精和吸毒问题的最密切的相关性，饮酒尤其是与同龄人共享的社交活动。这些神经发育和同伴对然后，奖励网络可能是关键的神经生物学和上下文机制，可以说明大型青春期中酒精和药物使用问题的增加。我们将研究奖励和认知控制的神经生物学过程的发展网络，对这些网络的同伴影响以及这些神经生物学和上下文过程如何贡献使用纵向fMRI研究，在青春期进行冒险，酒精和吸毒问题。我们将使用加速的纵向队列设计，涵盖了（10 - 2年），中年（13-15岁），并且后来（16-18岁）青春期（总n = 210），进行了1年和2年的随访评估。这个设计一半的时间将使我们能够覆盖神经生物学发展的10年（10至20岁）。我们的协议将包括评估在冒险期间对奖励激活的同伴存在（停机任务）并奖励预期和收据（货币激励延迟）；与显式相关的神经过程以接受和拒绝形式的社会反馈（聊天室社交互动任务）；和基本认知控制任务（停止信号）以评估抑制过程。我们预测同伴的存在将增加冒险和奖励收据期间的奖励激活，并且这些对奖励激活的同伴影响将会从青春期前到中期增加。此外，更大的奖励反应性和较弱的认知控制将会与对同伴影响更大的敏感性有关。最后，更大的奖励反应性，认知弱控制，对同伴的存在和明确的社会反馈都更加敏感更大的酒精和药物使用问题以及合并的外部化和内在化问题。