The ANTIDOTE Institute- Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts

ANTIDOTE Institute - 推动新毒理学研究人员在药物滥用和原创转化研究工作中的发展

• 批准号: 10681927
• 负责人: STEPHANIE P CARREIRO
• 金额: $ 30.2万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681927
• 关键词: Acceleration; Address; Adverse drug event; American; Awareness; Behavioral; Behavioral Sciences; Board Certification; Career Mobility; Caring; Clinical; Collaborations; Data; Dedications; Development; Diagnosis; Discipline; Drug abuse; Education Gap; Educational Curriculum; Epidemic; Epidemiology; Evaluation; Faculty; Funding; Goals; Grant; Group Meetings; Health; Health system; Hybrids; Instruction; Investigation; Learning; Learning Skill; Measures; Medical; Medicine; Mental disorders; Mentors; Mentorship; Methodology; Modeling; National Institute of Drug Abuse; Patient Care; Patients; Persons; Pharmaceutical Preparations; Pharmacotherapy; Physicians; Poison; Poisoning; Population; Positioning Attribute; Program Development; Program Evaluation; Public Health; Reaction; Records; Research; Research Methodology; Research Personnel; Role; Scientist; Structure; Substance Use Disorder; Substance of Abuse; Therapeutic Uses; Toxicology; Training; Training Programs; Translating; Translational Research; Trauma; United States; Writing; behavior change; career; cohort; comorbidity; experience; innovation; interdisciplinary approach; interest; knowledge translation; medical schools; medical specialties; meetings; member; multidisciplinary; next generation; novel therapeutics; outreach; pharmacokinetics and pharmacodynamics; pharmacologic; programs; recruit; research and development; response; satisfaction; skill acquisition; skills; social stigma; success; theories; tool; virtual; virtual group

PROJECT SUMMARY/ABSRACT This proposal is responsive to PAR-21-320 with two overarching goals: 1) to provide empiric training in research methodology and hypothesis-driven research, and 2) to train a diverse cadre of clinical medical toxicologists as independent researchers at the intersection of substance use disorder (SUD) and public health. The epidemics of SUD are in sore need of innovation and diversity among researchers. Medical Toxicology is a field of medicine dedicated to the evaluation and treatment of poisoned patients, including adverse health effects of drugs and illicit substances. Medical toxicologists have a track record of innovation and public health-relevant research in SUD; however, few pursue careers as independent, federally funded investigators. In response to this gap in our specialty, we developed in collaboration with the American College of Medical Toxicology, a hybrid research mentorship program, the ANTIDOTE (Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts) Institute. The ANTIDOTE Institute provides structured research methodology training and mentorship to medical toxicologists with a long-term goal of developing a pipeline of medical toxicology physician scientists that achieve independent federal funding in SUD research. This R25 proposes to formalize ANTIDOTE by extending our curriculum for a more rigorous training experience, providing seed funding to accelerate the progress of institute fellows in SUD research, and expanding institute activities to include outreach and multi-generational mentorship. The expanded two-year ANTIDOTE curriculum will be delivered using a hybrid approach including in-person retreats, virtual group meetings/didactics, and virtual one-on-one meetings. We have assembled a strong multi- disciplinary faculty who are experts in research methodology, innovators in the care of SUD, and master educators. The Specific Aims of this proposal are: 1) To expand, implement and widely disseminate the ANTIDOTE institute with a curriculum grounded in Participatory Learning Theory to support the development of toxicologists as clinician scientists: 2) To evaluate the impact of the ANTIDOTE institute using a validated program evaluation tools: and 3) To facilitate and sustain the development of a diverse investigator pipeline in medical toxicology, through training in mentorship skills, knowledge translation and outreach. The ANTIODTE Institute is the first program of its kind to systematically address educational gaps within medical toxicology training around developing hypothesis-driven research investigations. Successful expansion of the program will facilitate methodologically rigorous and clinically informed research on SUD and create a national network of diverse investigators to sustain this momentum. This framework can then be translated outside of the field of medical toxicology to facilitate pipeline development in other clinical specialties.

项目概要/摘要 该提案响应 PAR-21-320，具有两个总体目标：1) 提供经验培训 研究方法和假设驱动的研究，2) 培养多元化的临床医学骨干队伍 毒理学家作为物质使用障碍 (SUD) 和公众交叉点的独立研究人员 健康。 SUD 的流行迫切需要研究人员的创新和多样性。医疗的 毒理学是致力于评估和治疗中毒患者的医学领域，包括 药物和非法物质对健康的不利影响。医学毒理学家拥有创新记录 以及 SUD 中公共卫生相关的研究；然而，很少有人从事独立的、联邦资助的职业 调查人员。为了弥补我们专业上的这一差距，我们与美国合作开发了 医学毒理学学院，一个混合研究指导计划，ANTIDOTE（推进新 药物滥用毒理学研究人员和原创转化研究工作）研究所。解药 研究所为医学毒理学家提供结构化研究方法培训和指导 长期目标是开发一批医学毒理学医师科学家，以实现独立 SUD 研究的联邦资助。该 R25 建议通过扩展我们的课程来正式化 ANTIDOTE 更严格的培训经验，提供种子资金，加速SUD研究院研究员的进步 研究，并扩大研究所的活动，包括外展和多代指导。这 扩展的两年制 ANTIDOTE 课程将采用混合方法提供，包括面对面授课 静修、虚拟小组会议/教学以及虚拟一对一会议。我们集结了强大的多方力量 学科教师是研究方法方面的专家、SUD 的创新者和硕士 教育工作者。该提案的具体目标是： 1) 扩大、实施和广泛传播 ANTIDOTE 学院的课程以参与式学习理论为基础，支持发展 毒理学家作为临床科学家：2) 使用经过验证的方法来评估 ANTIDOTE 研究所的影响 项目评估工具：以及 3) 促进和维持多元化研究者渠道的发展 医学毒理学，通过指导技能、知识转化和推广方面的培训。解药 该研究所是同类中第一个系统地解决医学毒理学教育差距的项目 围绕开展假设驱动的研究调查进行培训。该计划的成功扩展将 促进方法论上严格和临床知情的 SUD 研究，并创建一个全国网络 多样化的研究人员来维持这一势头。这个框架可以被翻译到领域之外 医学毒理学，以促进其他临床专业的管道开发。