SHARE Program: Innovations in Translational Behavioral Science to Improve Self-management of HIV and Alcohol Reaching Emerging adults

SHARE 计划：转化行为科学创新，以改善新兴成年人对艾滋病毒和酒精的自我管理

• 批准号: 10678982
• 负责人: Karen MacDonell
• 金额: $ 128.5万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678982
• 关键词: Address; Adult; Age; Alcohol consumption; Alcohols; Basic Behavioral Science; Behavior; Behavior Therapy; Behavioral; Behavioral Sciences; Behavioral trial; Big Data; Caring; Chronic Disease; Communities; Competence; Data Science Core; Decision Making; Development; Disease Progression; Elderly; Electronic Health Record; Ensure; Epidemic; Face; Feedback; Florida; Foundations; Goals; HIV; HIV Infections; HIV diagnosis; HIV/AIDS; Health; Individual; Intervention; Life; Life Style; Link; Literature; Mental Health; Methods; Modeling; Monitor; Motivation; Neurocognition; Outcome; Persons; Phase; Physical activity; Problem Solving; Program Research Project Grants; Psychological reinforcement; Public Health; Research; Research Project Grants; Risk; Risk Behaviors; Risk Taking; Role; Self Management; Self-control as a personality trait; Sleep; Stress; Substance abuse problem; Technology; Testing; Tobacco; Translating; Translations; United States; United States National Institutes of Health; Viral; Viral Load result; Work; Youth; age group; alcohol comorbidity; alcohol monitoring; community engagement; community partnership; comorbidity; comparative effectiveness trial; efficacious intervention; emerging adult; emerging adulthood; expectation; improved; innovation; intervention program; medication compliance; new technology; physical conditioning; programs; psychosocial; recruit; scale up; secondary analysis; skills; social; social stigma; substance use; symptom management; therapy design; therapy development; translational pipeline; translational study; transmission process; treatment as prevention

SHARE P01 ABSTRACT The purpose of the SHARE P01 research program project is to address HIV and alcohol use around three themes; 1) Emerging adulthood (ages 18 -29); 2) Self-management of HIV and alcohol; and 3) Translational behavioral science. Emerging adulthood is a developmental stage marked by significant change in social roles, expectations as a new adult, and increased responsibilities. It is also marked by poor HIV self- management and increased alcohol use. Emerging adults with HIV (hereafter called young people living with HIV; YPLWH) may face even more challenges given intersectional stigma. This age group continues to have very high rates of new HIV infections. Interventions designed specifically for the unique developmental challenges of emerging adults are needed, yet emerging adults are often included with older adults in intervention programs. The concept of self-management emerged concurrently within both the substance abuse and chronic illness literatures, and fits well with the developmental challenges of emerging adulthood. Self-management, a framework we have utilized in our work with YPLWH, refers to the ability to manage symptoms, treatments, lifestyle changes, and consequences of health conditions. Current research now identifies individual-level self-management skills such as self-control, decision-making, self-reinforcement, and problem solving as that protect against substance use and improve other health outcomes and can be embedded in the Information-Motivation-Behavioral Skills model. Although we have conducted multiple studies with YPLWH, only one intervention to date (Healthy Choices conducted by our team) improved both alcohol use and viral suppression in YPLWH in large trials. The goal of the SHARE P01 is to utilize advances in translational behavioral science to optimize behavioral interventions and define new developmentally- and culturally-appropriate intervention targets to improve self-management of alcohol and HIV in YPLWH. We will focus our efforts in Florida, a state hardest hit by the HIV epidemic but with a particularly strong academic- community partnership to support translation. We have assembled research teams to conduct self- management studies across the translational spectrum to address self-management and improve alcohol use and viral suppression (and thereby reduce transmission) in diverse YPLWH in Florida. The P01 will consist of three research projects (DEFINE, ENGAGE, and SUSTAIN), representing different stages on the translational spectrum and targeting different core competencies, supported by two cores (Community Engagement Core and Data Science Core). If successful, the SHARE P01 has the potential to greatly advance programs promoting self-management of HIV and alcohol use among a particularly vulnerable, but under-researched group, emerging adults living with HIV. SHARE also has a high potential for scale-up and implementation beyond Florida and across the United States.

分享 P01 摘要 SHARE P01 研究计划项目的目的是解决大约三岁左右的艾滋病毒和酒精使用问题 主题； 1) 成年初期（18 -29 岁）； 2）艾滋病毒和酒精的自我管理； 3) 翻译 行为科学。成年初期是一个以社会发生重大变化为标志的发展阶段 作为一个新成年人的角色、期望以及增加的责任。它的另一个特点是艾滋病病毒自我感染能力较差。 管理和增加饮酒。感染艾滋病毒的新成人（以下称为感染艾滋病毒的年轻人） 艾滋病病毒;鉴于交叉耻辱，YPLWH）可能面临更多挑战。这个年龄段继续有 新发艾滋病毒感染率非常高。专为独特的发展而设计的干预措施 新兴成年人面临的挑战是必要的，但新兴成年人往往与老年人一起生活 干预计划。自我管理的概念在实质内容中同时出现 虐待和慢性病文献，并且非常适合成年初期的发展挑战。 自我管理是我们在 YPLWH 工作中使用的一个框架，指的是管理的能力 症状、治疗、生活方式的改变以及健康状况的后果。目前研究现状 识别个人层面的自我管理技能，例如自我控制、决策、自我强化和 解决问题，防止药物滥用并改善其他健康结果，并且可以 嵌入信息-动机-行为技能模型中。虽然我们已经进行了多次 与 YPLWH 的研究表明，迄今为止只有一项干预措施（我们团队进行的健康选择）改善了两者 大型试验中 YPLWH 的饮酒和病毒抑制。 SHARE P01 的目标是利用先进技术 在转化行为科学中优化行为干预并定义新的发展和 适合文化的干预目标，以改善 YPLWH 中酒精和艾滋病毒的自我管理。我们将 我们将重点放在佛罗里达州，该州是艾滋病毒流行最严重的州，但学术实力特别强。 支持翻译的社区伙伴关系。我们组建了研究团队进行自我研究 跨转化领域的管理研究，以解决自我管理和改善饮酒的问题 佛罗里达州不同 YPLWH 中的病毒抑制（从而减少传播）。 P01 将包括 三个研究项目（DEFINE、ENGAGE 和 SUSTAIN），代表转化的不同阶段 频谱并针对不同的核心能力，由两个核心（社区参与核心 和数据科学核心）。如果成功，SHARE P01 有潜力极大地推进项目 促进特别脆弱但研究不足的人群对艾滋病毒和酒精使用的自我管理 群体，新兴的艾滋病毒感染者。 SHARE 还具有很大的扩大和实施潜力 超越佛罗里达州和美国各地。