Core Facilities for Vision Research

视觉研究核心设施

基本信息

批准号：
10681422
负责人：
MICHAEL E. GOLDBERG
金额：
$ 80.84万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10681422
关键词：
Animals Behavior Biochemical Blindness Brain Center Core Grants Clinical Collaborations Communities Computer Hardware Computer software Computers Core Facility Core Grant Custom Data Data Analyses Data Storage and Retrieval Databases Dedications Development Diagnostic Disease Drosophila genus Educational process of instructing Electronics Emergency Situation Equipment Eye Eye Development Eye diseases Fluorescence Microscopy Functional disorder Funding Funding Mechanisms Genetic Genetic study Genomics Glaucoma Grant Health Insurance Portability and Accountability Act Histologic Histology Human Image Individual Laboratories Light Macular degeneration Maintenance Microscopic Microscopy Modification Mus Myopia National Eye Institute Neurosciences Oryctolagus cuniculus Participant Patients Postdoctoral Fellow Privatization Process Qualifying Research Research Personnel Research Project Grants Research Support Resources Retina Retinal Diseases Retinitis Pigmentosa Rodent Scientist Security Sequence Analysis Services System Techniques Technology Time Training United States National Institutes of Health Universities Vision Vision research Visual Work clinical database data integration database design design fabrication fluorescence microscope genetic analysis improved in vivo in vivo imaging instrument instrumentation light microscopy member neurophysiology new technology ocular angiogenesis oculomotor behavior programs repaired student training tissue culture tissue preparation vision science

项目摘要

Project Summary/Abstract Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 25 qualifying R01 grants and 48 vision scientists in all. Vision research at Columbia ranges across a gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to studies of human retinal disease. Computational, neurophysiological, light microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology, genetics, and treatment of retinal diseases such as macular degeneration, retinitis pigmentosa, myopia, and glaucoma. To support this vision research, we are applying to renew our National Eye Institute grant P30 EY019007, which will continue to support a set of Core Facilities for Vision Research and enable services that could not be provided by individual research grants. The grant supports three research cores: i) an Instrumentation Fabrication and Design Core that designs and builds custom equipment; ii) a Computer Core that performs support and maintenance for the hundreds of computers, including real-time laboratory computer-based interface used by the vision research community, handles research-specific database design, integrated data storage, management and analysis with the new Genomics Analysis Suite; and iii) an Imaging, Histology and Functional Diagnostics Core, which provides histological, in vivo, fluorescent microscopy, OCT, and ERG services. The grant not only supports currently funded investigators with NEI R01s, but also aids the work of vision scientists supported by other NEI funding mechanisms, other NIH institutes, and, importantly, young investigators gathering data in order to submit their first NEI grants. This grant facilitates collaboration among members of the Columbia vision research community, and encourages scientists not currently engaged in vision research to use their expertise in problems related to vision.

项目概要/摘要哥伦比亚大学拥有一个由国家眼科支持的大型且充满活力的视觉研究社区研究所，共有 25 名合格的 R01 资助人和 48 名视觉科学家。哥伦比亚山脉的视觉研究涵盖一系列主题，从果蝇和小鼠视网膜和视觉大脑发育的遗传学研究人类视网膜疾病的研究。计算、神经生理学、光显微镜、遗传学、生物化学和临床技术专注于一系列问题，包括眼睛的发育和视觉脑、眼部血管生成机制、视觉和动眼神经系统神经科学行为、病理生理学、遗传学和黄斑变性等视网膜疾病的治疗，视网膜色素变性、近视和青光眼。为了支持这项愿景研究，我们正在申请更新我们的国家眼科研究所拨款 P30 EY019007，将继续支持一套视觉核心设施研究并提供个人研究资助无法提供的服务。该补助金支持三个研究核心：i) 仪器制造和设计核心，用于设计和构建定制设备; ii) 为数百台计算机提供支持和维护的计算机核心，包括视觉研究界使用的实时实验室计算机界面，处理研究专用数据库设计，利用新基因组学集成数据存储、管理和分析分析套件； iii) 影像、组织学和功能诊断核心，提供组织学、 vivo、荧光显微镜、OCT 和 ERG 服务。该赠款不仅支持目前资助的 NEI R01 的研究人员，还帮助其他 NEI 资金支持的视觉科学家的工作机制、其他 NIH 机构，以及重要的是，年轻的研究人员收集数据以提交他们的报告第一个 NEI 补助金。这笔赠款促进了哥伦比亚视觉研究成员之间的合作社区，并鼓励目前未从事视觉研究的科学家利用他们的专业知识与视力有关的问题。

项目成果

期刊论文数量（258）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

CHARGE syndrome with de novo frameshift mutation in a patient with total retinal detachment and large choroidal coloboma.

患有完全视网膜脱离和大脉络膜缺损的患者出现 CHARGE 综合征，伴有从头移码突变。

DOI：
发表时间：
2022-03
期刊：
影响因子：
0
作者：
Yu;Wang, Nan;Wu, Wei
通讯作者：
Wu, Wei

Mixed Selectivity in the Cerebellar Purkinje-Cell Response during Visuomotor Association Learning.

视觉运动关联学习期间小脑浦肯野细胞反应的混合选择性。

DOI：
发表时间：
2022-05-04
期刊：
影响因子：
0
作者：
Sendhilnathan, Naveen;Goldberg, Michael E;Ipata, Anna E
通讯作者：
Ipata, Anna E

The Association of Intravitreal Injections of Different Anti-Vascular Endothelial Growth Factor with Systemic Outcomes in Diabetic Patients.

玻璃体内注射不同抗血管内皮生长因子与糖尿病患者全身结局的关系。

DOI：
发表时间：
2023-03-18
期刊：
影响因子：
0
作者：
Kang, Eugene Yu;Lin, Tzu;Garg, Sunir J;Wang, Nan;Chen, Lee;Huang, Pei;Chan, Ming;Chen, Kuan;Wu, Wei;Lai, Chi;Hwang, Yih
通讯作者：
Hwang, Yih

Scleral Thickness in Autosomal Dominant Best Vitelliform Macular Dystrophy.

常染色体显性遗传性最佳卵黄样黄斑营养不良的巩膜厚度。