Core Support for Vision Research

视觉研究的核心支持

基本信息

批准号：
8698753
负责人：
MICHAEL E. GOLDBERG
金额：
$ 78.3万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8698753
关键词：
Advanced Glycosylation End Products Age related macular degeneration Amygdaloid structure Animal Model Animals Award Basic Science Behavior Binding Proteins Biochemical Biomedical Engineering Biophysics Blindness Blood Blood - brain barrier anatomy Brain Cancer Center Support Grant Cell Therapy Cerebrum Circadian Rhythms Clinical Clinical Research Clinical Sciences Cognitive Collaborations Communities Computer Simulation Computers Consultations Core Facility Data Decision Making Development Diagnosis Discipline Disease Doctor of Philosophy Drosophila genus Drug Delivery Systems Electroencephalography Electrons Enrollment Environment Epidemiologic Studies Etiology Exposure to Eye Eye Development Eye diseases Faculty Fertilization Floor Fluorescence Foundations Functional Magnetic Resonance Imaging Functional disorder Funding Genetic Genetic Variation Grant Hereditary Disease Human Image Individual Institutes Institution Israel Keratoconus Kindling (Neurology)Life Light Lipofuscin Macaca mulatta Macular degeneration Maintenance Mathematics Medical center Mentors Methods Microscopic Microscopy Modeling Molecular Monkeys Mus National Eye Institute National Heart, Lung, and Blood Institute National Institute of Child Health and Human Development National Institute of Drug Abuse National Institute of General Medical Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Research Service Awards Neurobiology Neurology Neurons Neurosciences New York Object Attachment Ocular Physiology Ophthalmologist Ophthalmology Optics Pathology Patients Pharmaceutical Preparations Physiological Physiology Postdoctoral Fellow Principal Investigator Problem Solving Process Property Psychiatry Psychophysics Qualifying Research Research Personnel Research Project Grants Resolution Retina Retinal Retinal Degeneration Retinal Diseases Retinopathy of Prematurity Rotation Running Science Scientist Senior Scientist Services Space Perception Sparrows Stem cells Structure Students System Techniques Telemedicine Time Training Training Programs Training Support Translational Research United States National Institutes of Health Universities Vision Vision research Visual Visual Cortex Visual Pathways Visual Perception Visual attention Visual system structure Visuospatial Washington Work active vision awake axon guidance base brain behavior computational neuroscience design extrastriate visual cortex fly gene therapy graduate student in vivo instrumentation interest light entrainment macula member mouse model multidisciplinary neurophysiology neurosurgery ocular angiogenesis ocular surface oculomotor oculomotor behavior optic nerve disorder optical imaging pre-doctoral professor programs protein structure receptor for advanced glycation endproducts retinal angiogenesis screening small molecule statistics vision development vision science visual memory visual neuroscience visual search

项目摘要

DESCRIPTION (provided by applicant): Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 20 qualifying grants. Vision research at Columbia ranges across a huge gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to epidemiological studies of the behavior of patients with eye disease. Computational, neurophysiological, light and electron microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology and treatment of retinal diseases such as macular degeneration. To support this vision research we are requesting the establishment of a National Eye Institute supported set of Core Facilities for Vision Research, to provide services that could not be provided by individual research grants. The proposed core will have three modules: a instrumentation fabrication and design module which will be the successor of a similar module which was funded by an NEI program which cannot be renewed; a computer support module which will include offsite data backup, support and maintenance for the hundreds of computers, including an X-grid cluster, used by the vision research community, and a microscopic imaging module which will provide histological and in vivo and fluorescent microscopy services. This core will also facilitate collaboration among members of the Columbia vision research community, and encourage scientists not currently engaged in vision research to use their expertise to solve problems related to vision.

描述（由申请人提供）：哥伦比亚大学拥有一个由国家眼科研究所支持的大型且充满活力的视觉研究社区，拥有 20 项合格资助。哥伦比亚大学的视觉研究涉及广泛的主题，从果蝇和小鼠视网膜和视觉大脑发育的遗传学研究到眼病患者行为的流行病学研究。计算、神经生理学、光和电子显微镜、遗传、生化和临床技术关注一系列问题，包括眼睛和视觉大脑的发育、眼部血管生成的机制、视觉和动眼行为的系统神经科学以及黄斑变性等视网膜疾病的病理生理学和治疗。为了支持这项视力研究，我们要求建立国家眼科研究所支持的一套视力研究核心设施，以提供个人研究资助无法提供的服务。拟议的核心将包含三个模块：仪器制造和设计模块，该模块将是由 NEI 计划资助且无法更新的类似模块的后继者；计算机支持模块将包括数百台计算机的异地数据备份、支持和维护，包括视觉研究界使用的 X 网格集群，以及提供组织学、体内和荧光显微镜服务的显微成像模块。该核心还将促进哥伦比亚视觉研究界成员之间的合作，并鼓励目前未从事视觉研究的科学家利用他们的专业知识来解决与视觉相关的问题。