STRUCTURAL BIOLOGY CORE

结构生物学核心

• 批准号: 8364943
• 负责人: BRIAN J BAHNSON
• 金额: $ 17.9万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364943
• 关键词: Biochemistry; Biological; Centers of Research Excellence; Chemistry; Contracts; Crystallography; Faculty; Funding; Goals; Grant; Housing; Maintenance; Membrane Proteins; Methodology; Methods; National Center for Research Resources; Nuclear Magnetic Resonance; Pilot Projects; Principal Investigator; Production; Protein Structure Initiative; Proteins; Research; Research Infrastructure; Resources; Services; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; cost; instrument; structural biology; Biochemistry; Biological; Centers of Research Excellence; Chemistry; Contracts; Crystallography; Faculty; Funding; Goals; Grant; Housing; Maintenance; Membrane Proteins; Methodology; Methods; National Center for Research Resources; Nuclear Magnetic Resonance; Pilot Projects; Principal Investigator; Production; Protein Structure Initiative; Proteins; Research; Research Infrastructure; Resources; Services; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; cost; instrument; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Structural Biology core covers the two methods most widely used in the structural biology of proteins, namely biomacromolecular X-ray crystallography and nuclear magnetic resonance (NMR); both facilities are housed in the Department of Chemistry and Biochemistry. Because of the significant overlap between the scientific goals of the COBRE and those of two major NIH initiatives, the Structural Biology component of the NIH Roadmap and the Protein Structure Initiative, a structural biology capability is essential to the COBRE. The X-ray crystallography capability in the Core is the only macromolecular crystallography facility on campus and serves labs investigating structure-function relations of proteins. The NMR facility is much broader, but the COBRE focus is on only biological NMR, for which one instrument provides the bulk of the services. An additional feature of the NMR structural biology activity is the new methodology being developed; two NMR spectroscopists are among the COBRE faculty, and research in their labs is currently supported by COBRE pilot project grants. Support for the Structural Biology Core is for partial funding of postdoctoral staff, maintenance contracts and supplies.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 结构生物学核心涵盖了蛋白质结构生物学中最广泛使用的两种方法，即生物百形分子X射线晶体学和核磁共振（NMR）；这两个设施都位于化学和生物化学系。由于毛茸茸的科学目标与两个主要NIH计划的科学目标之间存在显着重叠，NIH路线图的结构生物学组成部分与蛋白质结构倡议的结构生物学成分，结构生物学能力对于毛病至关重要。核心中的X射线晶体学能力是校园上唯一的大分子晶体学设施，并为研究蛋白质结构功能关系提供了实验室。 NMR设施更广泛，但是毛绒的重点仅仅是生物NMR，其中一种仪器为此提供了大部分服务。 NMR结构生物学活性的另一个特征是开发的新方法。两名NMR光谱学家是柯布雷教职员工之一，目前在实验室中的研究得到了Cobre Pilot Project Grants的支持。对结构生物学核心的支持是为博士后人员，维护合同和用品提供部分资金。