Establishing Reference Values and Clinical Decision Points for Quantitative Videofluoroscopic Measures of Swallowing

建立吞咽定量电视透视测量的参考值和临床决策点

• 批准号: 10673194
• 负责人: Emily Kate Plowman
• 金额: $ 91.33万
• 依托单位: UNIVERSITY HEALTH NETWORK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673194
• 关键词: Accounting; Address; Adult; Age; Aging; Agreement; Amyotrophic Lateral Sclerosis; Area; Barium; Blood Tests; Bolus Infusion; COVID-19 survivors; Cardiovascular system; Caregivers; Cholesterol; Chronic Obstructive Pulmonary Disease; Clinical; Clinical Trials; Data; Deglutition; Deglutition Disorders; Diabetes Mellitus; Diagnosis; Diagnostic; Diet; Disease; Effectiveness; Elderly; Event; Functional disorder; Goals; Health; Height; Impairment; Injury; Intensive Care; International; Intervention; Knowledge; Longevity; Measurement; Measures; Mechanical ventilation; Medicine; Methods; Monitor; Morbidity - disease rate; Nature; Operative Surgical Procedures; Outcome Measure; Parkinson Disease; Participant; Patient Education; Patient-Focused Outcomes; Patients; Pediatrics; Physiological; Physiology; Population; Process; Protocols documentation; Publications; Publishing; Quality of life; Reference Values; Research; Resources; Sample Size; Sampling; Severities; Severity of illness; Stroke; Testing; Texture; Therapeutic; Tongue; Translations; United States; Variant; Vision; Weight; Work; age related; bench to bedside; clinical risk; cohort; cost; empowerment; evidence base; healthy aging; high risk; improved; indexing; individualized medicine; kinematics; patient population; prospective; scale up; sex; treatment planning; uptake

Project Summary/Abstract Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international “gold standard” dysphagia diagnostic exam, there is a paucity of available normative physiologic VF reference values in healthy adults across the age span to guide interpretation of this examination. This fundamental gap in knowledge contributes to poor agreement in the identification of swallowing impairment and its underlying mechanisms. To enable better dysphagia diagnostics, there is a critical need to establish reference values for VF swallowing measures across the healthy age span. In our previous R01 (DC011020), we developed a rigorous method for measuring swallowing physiology from VF: the Analysis of Swallowing Physiology: Events, Kinematics and Timing (ASPEKT Method). We published initial ASPEKT reference values from 40 young healthy adults (<60 years) and performed preliminary analyses to compare data from healthy older adults and small cohorts of adults with dysphagia to these reference data. Through this renewal application, we will validate the ASPEKT Method healthy reference values for swallowing across the adult life span, demonstrate scalability of the ASPEKT Method across commonly used variations in clinical VF testing protocols, and profile swallowing pathophysiology in clinical groups where dysphagia is a cause of morbidity to identify clinical decision points that can be used for diagnosis and outcome measurement. Our vision is that the ASPEKT Method will enable clinicians to compare patient measures to healthy reference values, facilitating quantification and evidence- based interpretation of the presence, nature and severity of swallowing impairment. Ultimately, we seek to generate data that will shift subjective dysphagia diagnostic practices toward a quantitative, evidence-based diagnostic framework that will improve resource utilization, treatment planning and patient outcomes.

项目概要/摘要 吞咽困难（吞咽障碍）是一种严重的健康状况，常见于许多与年龄相关的疾病和损伤 尽管视频荧光镜检查 (VF) 是一项国际“金标准”吞咽困难诊断检查， 各个年龄段的健康成年人缺乏可用的规范性生理室颤参考值 指导本次考试的解释。这种基本的知识差距导致了不一致。 识别吞咽障碍及其潜在机制，以实现更好的吞咽困难。 诊断中，迫切需要为健康人群建立 VF 吞咽测量的参考值 在我们之前的 R01 (DC011020) 中，我们开发了一种严格的吞咽测量方法。 VF 生理学：吞咽生理学分析：事件、运动学和计时（ASPEKT 方法）我们公布了 40 名年轻健康成年人（<60 岁）的初始 ASPEKT 参考值和 进行了初步分析，以比较健康老年人和小群患有糖尿病的成年人的数据 通过此更新应用程序，我们将验证 ASPEKT 方法。 整个成人生命周期吞咽的健康参考值，展示了 ASPEKT 的可扩展性 临床心室颤动测试方案中常用变化的方法以及吞咽情况 吞咽困难是发病原因的临床群体的病理生理学，以确定临床决策点 我们的愿景是，ASPEKT 方法将能够用于诊断和结果测量。 战士将患者测量值与健康参考值进行比较，促进量化和证据- 最终，我们寻求对吞咽障碍的存在、性质和严重程度进行解释。 生成数据，将主观吞咽困难诊断实践转向定量、基于证据的方法 诊断框架将改善资源利用率、治疗计划和患者结果。

项目成果

Dysphagia in Open Partial Horizontal Laryngectomy Type IIa: Quantitative Analysis of Videofluoroscopy using the ASPEKT Method.

IIa 型开放性部分水平喉切除术中的吞咽困难：使用 ASPEKT 方法对视频荧光镜检查进行定量分析。

• 发表时间: 2024-03-03
• 影响因子: 2.6
• 作者: da Costa Miranda Barbosa, Raphaela;de Freitas, Andressa Silva;Cerqueira, Rayane Beltrão Alves;Mancopes, Renata;Dias, Fernando Luiz;Steele, Catriona M
• 通讯作者: Steele, Catriona M