Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence

青春期大脑、神经认知和青春期成熟的成像

基本信息

批准号：
8316333
负责人：
ELIZABETH R SOWELL
金额：
$ 65.73万
依托单位：
CHILDREN'S HOSPITAL OF LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-21 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8316333
关键词：
15 year old Address Adolescence Adolescent Adult Affect Affective Age Amygdaloid structure Animals Anisotropy Anxiety Behavior Behavioral Bilateral Brain Brain imaging Brain region Cell physiology Child Childhood Cognition Cognitive Competence Data Depressed mood Depression and Suicide Development Diffusion Magnetic Resonance Imaging Dissociation Dorsal Emotional Emotions Environmental Risk Factor Equilibrium Estrogens Face Face Processing Facial Expression Female Fiber Functional Imaging Functional Magnetic Resonance Imaging Gender Genetic Goals Gonadal Steroid Hormones Health Hippocampus (Brain)Hormonal Hormones Human Hydrocortisone Image Analysis Impulsivity Individual Inferior Lateral Left Literature Magnetic Resonance Imaging Maps Measures Medial Mediating Mediation Mental Health Mental disorders Modeling Motivation Multimodal Imaging NIH Program Announcements National Institute of Mental Health Neurocognitive Neurosecretory Systems Occipital lobe Outcome Parietal Lobe Participant Pattern Performance Phase Prefrontal Cortex Process Psychopathology Puberty Radial Relative (related person)Reporting Research Research Personnel Rewards Risk Risk Assessment Saliva Sampling Scanning Sex Characteristics Sexual Maturation Signal Transduction Social Change Social Functioning Social Interaction Staging Stress Structure Study Subject Substance abuse problem Synapses System Task Performances Temporal Lobe Testing Testosterone Thick Time Visual Work Youth age effect age related analog area striata association cortex base behavior test boys brain behavior cognitive control cognitive function dehydroepiandrosterone density diaries discounting executive function frontal lobe frontal lobe cortex functional status girls gray matter improved indexing interest male multidisciplinary myelination neurocognitive test neuroimaging relating to nervous system response reward processing sex standardize measure white matter

项目摘要

DESCRIPTION (provided by applicant): Enormous progress has been made recently in understanding the age-related structural maturational changes that occur in the human brain during childhood and adolescence, but variability in brain structure is very large, even among individuals of the same chronological age. The literature suggests an offset in development of limbic structures which control affect, emotion, encoding information, which may develop prior to the executive centers (frontal cortices) that provide regulatory control over impulses and risk assessment. Almost nothing is yet known about neurodevelopmental, neuroendocrine, behavioral and environmental factors that likely relate to variability in brain structure and function, and cognitive abilities that change so dramatically during adolescence. In this project, we propose to longitudinally study 120 typically developing adolescents between 9 and 15 years of age with 2-year scan intervals, and to collect brain imaging (structural MRI, diffusion tensor imaging and functional MRI with tasks of response inhibition, reward processing, delayed discounting, facial affect processing), neurocognitive (with emphasis on executive functioning and cognitive control), physical sexual maturation (using Tanners staging), and hormonal (cortisol, testosterone, estrogen and Dehydroepiandrosterone (DHEA) using saliva samples) data as well as measures of daily stress. With these rich multimodal imaging, behavioral, cognitive and hormonal data, we will address the following specific aims: 1) to distinguish hormone-dependent from non-hormone dependent neurodevelopmental effects in adolescence, 2) to evaluate relationships between brain changes and behavioral indices of cognition (cognitive control, executive functions, daily stress) and motivation (e.g., reward sensitivity), and 3) to evaluate gender differences in relationships between brain changes and indices of pubertal progression. To our knowledge, this will be the first study to undertake such challenges by using cutting-edge integrative multimodal image analyses of functional and structural MRI to examine, longitudinally, brain development in adolescents and to distinguish hormonal from other age-related environmental and behavioral correlates. PUBLIC HEALTH RELEVANCE: The proposed research to study adolescent brain development using integrated multimodal neuroimaging, neurocognitive, stress, and hormonal measures longitudinally in typically developing children and adolescents is of the utmost importance. The beginning of adolescence is a time of dramatic physical, emotional and social change, and is also associated with the onset of psychopathology such as depression, suicide, and substance abuse. To provide a framework for understanding how risks during adolescence can tip the balance toward pathological outcomes in youth and adulthood, models of typical brain development need to evaluate interactions between hormonal and physical sexual maturity and the still-maturing neural systems responsible for social interactions, affective states and cognitive control.

描述（由申请人提供）：最近在了解与年龄相关的结构性成熟变化时，在儿童期和青春期期间发生的与年龄相关的结构性成熟变化，但大脑结构的变化非常大，即使在同一年代年代的个体中，大脑结构的变化也很大。文献表明，控制，情感，编码信息的边缘结构的发展有抵消，这些信息可能在执行中心（额叶皮层）之前发展，该信息提供了对冲动和风险评估的监管控制。关于神经发育，神经内分泌，行为和环境因素可能与大脑结构和功能变化以及青春期巨大变化的认知能力有关的神经发育，行为和环境因素几乎一无所知。在这个项目中，我们建议纵向研究120个通常在9至15岁之间以2年扫描间隔开发青少年，并收集大脑成像（结构性MRI，扩散张量成像和功能性MRI，以及响应抑制，奖励处理，延迟折现，面部影响处理的响应抑制，延迟的折现，外观影响处理（伴随着效率）的（伴随着效力）（伴随着效力）（效率上）（效力）（依次），并确定有效性地努力，并确定了功能障碍（晒黑器分期）和激素（使用唾液样品的皮质醇，睾丸激素，雌激素和脱氢表雄酮（DHEA）数据）数据以及日常应激的测量。借助这些丰富的多模式成像，行为，认知和荷尔蒙数据，我们将解决以下特定目的：1）以区分非激素依赖性与非激素依赖性神经发育效应，以评估大脑变化和行为变化之间的关系，以评估大脑变化和差异（E. grivesitions and sistion genenter insive），奖励，奖励（E.G），奖励，奖励，奖励，奖励，奖励，奖励，奖励。大脑变化与青春期进展指数之间的关系。据我们所知，这将是第一项通过使用功能和结构MRI的最先进的综合多模式图像分析来进行此类挑战的研究。公共卫生相关性：拟议的研究旨在使用综合多模式神经影像学，神经认知，压力和荷尔蒙测量的综合性脑发育研究，在典型发展的儿童和青少年中纵向进行纵向。青春期的开始是一个戏剧性的身体，情感和社会变革的时期，也与抑郁症，自杀和滥用诸如精神病理学的开始有关。为了提供一个框架，以了解青春期的风险如何使平衡如何朝着青年和成年期的病理结果迈进，典型的大脑发展模型需要评估荷尔蒙和身体性成熟之间的相互作用，以及负责社交互动，情感状态和认知控制的仍在社交相互作用的神经系统之间的相互作用。