Brain and Cognitive Development in the PASS Cohort: The Impact of PrenatalAlcohol Exposure

PASS 队列中的大脑和认知发展：产前酒精暴露的影响

• 批准号: 10737503
• 负责人: ELIZABETH R SOWELL
• 金额: $ 60.1万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737503
• 关键词: 12 year old; 15 year old; 3-Dimensional; Address; Adolescence; Age; Alcohol consumption; Alcohols; Amygdaloid structure; Animal Experimentation; Animal Model; Back; Behavior; Birth; Brain; COVID-19 pandemic; Caregivers; Cerebellar vermis structure; Child; Childhood; Cognition; Cognitive; Cohort Studies; Corpus Callosum; Coupled; Data; Data Set; Development; Discipline of obstetrics; Dysmorphology; Early Intervention; Economics; Enrollment; Environment; Environmental Risk Factor; Exhibits; Exposure to; Face; Family; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; First Pregnancy Trimester; Frequencies; Funding; Hippocampus; Home; Human; Image; Impaired cognition; Income; Individual; Infant; Infrastructure; Intellectual functioning disability; Investigation; Knowledge; Life; Life Experience; Light; Longitudinal Studies; Maternal Age; Measures; Mediating; Medical; Mental Health; Morphology; Mothers; Nature; Outcome Measure; Participant; Patient Recruitments; Pattern; Perinatal; Population; Positioning Attribute; Poverty; Pregnancy; Prevalence; Problem behavior; Productivity; Prospective, cohort study; Publishing; Recording of previous events; Reporting; Research Design; Resources; Risk; Risk Factors; Sampling; Selection Criteria; Societies; South Africa; South African; Stress; Structure; Sudden infant death syndrome; Thick; Time; Tobacco use; Youth; alcohol exposure; binge drinking; cognitive development; cognitive function; cognitive testing; cohort; cost; drinking; drinking behavior; early childhood; early life adversity; environmental tobacco smoke exposure; experience; externalizing behavior; fetal tobacco exposure; girls; in utero; innovation; insight; low socioeconomic status; maternal alcohol use; maternal risk; neuroimaging; novel; nutrition; parity; perinatal period; postnatal; pregnant; prenatal; prospective; public health relevance; recruit; research study; resilience; social; stillbirth; substance use; toxicant; white matter

This is a competitive renewal application for R01-AA025653. Over the last 6 years, we have conducted neuroimaging studies in over 400 South African (SA) youth [8-12-years-old; ~300 with prenatal alcohol exposure (PAE) and ~100 non-exposed Controls (NC); 50% girls] from the Prenatal Alcohol, SIDS and Stillbirth (PASS) prospective birth cohort. The PASS cohort is comprised of ~6,000 SA children (born 2008- 2014; now ~8-15-years-old) whose mothers reported on drinking behavior during pregnancy. With pseudo- random selection criteria for the PAE participants recruited during the 1st funding period, the quantity of total drinks during pregnancy was (on average) quite low (range: ~1-611 drinks, M = 27.6, SD = 59.2 ). During this renewal period, we have the opportunity to extend recruitment to over-sample youth with much higher PAE quantities (range: ~32-817 drinks, M = 123.9, SD = 110.8). For renewal, we have developed a novel cohort- sequential cross-sectional/longitudinal study design, in which we would bring back ~50% of participants recruited during the 1st funding period (~150 PAE, ~50 NC) for longitudinal assessment of brain, cognition, and facial morphology (BCF), plus recruitment of ~250 new PASS participants (~200 PAE, ~50 NC). This will permit 1) recruitment of more highly exposed PAE participants to span the range of exposure, 2) study of a broader age range across adolescence among PAE and NC from 8 to 17 years during which dramatic brain development continues, and 3) utilization of data collected during the 1st 6 years both in the longitudinal component and with newly recruited participants in the cross-sectional component. Notably, most children with heavy PAE experience greater early life adversity than NC children, and early intervention is believed to be key in attenuating PAE-effects, the latter of which may depend, in part, on understanding the impact of quantity, frequency and timing (QFT) and early life experiences. Our history of productive team-work and existing infrastructure, coupled with experienced staff and collaborators in South Africa over the last 6 years, bode well for renewal, putting us in an exceptional position to further understanding how QFT of PAE independently, or interactively, impacts associations between (1) brain and cognition/behavior, (2) brain and early life environment, and (3) brain and facial morphology as function of environmental/maternal factors. We will use identical measures of brain structure/function, 3D facial imaging, cognition (WISC-V), early life experience (e.g., maternal age, nutrition, parity, mental health, substance use both perinatally and currently) and environmental risk factors (e.g., multiple measures of SES, access to resources, stress), measured perinatally and during childhood. Both cross-sectional and longitudinal quantitative measures from 3D facial imaging will be utilized in parallel with neuroimaging and cognitive assessments. Using the entire range of PAE, we expect independent and interactive (e.g., quantity by timing) effects of QFT on brain/cognition/face associations, with the largest effects driven by quantity, followed by frequency, and then timing of PAE.

这是 R01-AA025653 的竞争性续展申请。在过去的 6 年里，我们进行了 对 400 多名南非 (SA) 青少年 [8-12 岁；产前酒精约 300 暴露 (PAE) 和约 100 个非暴露对照 (NC)； 50% 的女孩]来自产前酒精、SIDS 和 死产（PASS）前瞻性出生队列。 PASS 队列由约 6,000 名 SA 儿童（2008 年出生 - 2014年；现在约 8-15 岁），其母亲报告了怀孕期间的饮酒行为。与伪 第一个资助期招募的 PAE 参与者的随机选择标准，总数量 怀孕期间的饮酒量（平均）相当低（范围：~1-611 杯，M = 27.6，SD = 59.2）。在此期间 续约期间，我们有机会将招募范围扩大到PAE更高的超样本青年 数量（范围：~32-817 杯饮料，M = 123.9，SD = 110.8）。为了更新，我们开发了一个新的队列 - 顺序横断面/纵向研究设计，其中我们将带回约 50% 的参与者 在第一个资助期（~150 PAE，~50 NC）招募，用于大脑、认知和功能的纵向评估 面部形态 (BCF)，加上招募约 250 名新 PASS 参与者（约 200 PAE，约 50 NC）。这将 允许 1) 招募更多高暴露 PAE 参与者以跨越暴露范围，2) 研究 PAE 和 NC 的青春期年龄范围更广，从 8 岁到 17 岁，在此期间大脑发生戏剧性的变化。 开发仍在继续，3）利用前 6 年中收集的数据进行纵向 部分以及横截面部分中新招募的参与者。值得注意的是，大多数儿童患有 重度 PAE 比非正常儿童经历更多的早期生活逆境，早期干预被认为是关键 减弱 PAE 效应，后者可能部分取决于对数量影响的理解， 频率和时间（QFT）和早期生活经历。我们富有成效的团队合作历史和现有的 基础设施，再加上过去 6 年在南非经验丰富的员工和合作者，这是一个好兆头 更新，使我们处于一个特殊的位置，可以进一步了解 PAE 的 QFT 如何独立，或 交互地影响 (1) 大脑和认知/行为，(2) 大脑和早期生活之间的关联 环境，以及（3）大脑和面部形态作为环境/母亲因素的函数。我们将使用 大脑结构/功能、3D 面部成像、认知 (WISC-V)、早期生活经历的相同测量 （例如，产妇年龄、营养、产次、心理健康、围产期和当前的物质使用情况）以及 围产期测量的环境风险因素（例如社会经济地位的多种衡量标准、资源获取、压力） 和童年时期。 3D 面部成像的横截面和纵向定量测量将 与神经影像学和认知评估并行使用。使用整个 PAE 范围，我们期望 QFT 对大脑/认知/面部关联的独立和交互（例如，时间的数量）影响 最大的影响是由数量驱动的，其次是频率，最后是 PAE 的时间。

项目成果

SrvfNet: A Generative Network for Unsupervised Multiple Diffeomorphic Functional Alignment.

• DOI: 10.1109/cvprw53098.2021.00505
• 发表时间: 2021-06
• 期刊: Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. Workshops
• 作者: Nunez, Elvis;Lizarraga, Andrew;Joshi, Shantanu H.
• 通讯作者: Joshi, Shantanu H.

Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective.

• DOI: 10.3389/fnint.2023.1104788
• 发表时间: 2023
• 期刊: FRONTIERS IN INTEGRATIVE NEUROSCIENCE
• 影响因子: 3.5
• 作者: Xia, Yingjing;Rebello, Vida;Bodison, Stefanie C.;Jonker, Deborah;Steigelmann, Babette;Donald, Kirsten A.;Charles, Weslin;Stein, Dan J.;Ipser, Jonathan;Ahmadi, Hedyeh;Kan, Eric;Sowell, Elizabeth R.;Narr, Katherine L.;Joshi, Shantanu H.;Odendaal, Hein J.;Uban, Kristina A.
• 通讯作者: Uban, Kristina A.