Brain and Cognitive Development in the PASS Cohort: The Impact of PrenatalAlcohol Exposure

PASS 队列中的大脑和认知发展：产前酒精暴露的影响

• 批准号: 10737503
• 负责人: ELIZABETH R SOWELL
• 金额: $ 60.1万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737503
• 关键词: 12 year old; 15 year old; 3-Dimensional; Address; Adolescence; Age; Alcohol consumption; Alcohols; Amygdaloid structure; Animal Experimentation; Animal Model; Back; Behavior; Birth; Brain; COVID-19 pandemic; Caregivers; Cerebellar vermis structure; Child; Childhood; Cognition; Cognitive; Cohort Studies; Corpus Callosum; Coupled; Data; Data Set; Development; Discipline of obstetrics; Dysmorphology; Early Intervention; Economics; Enrollment; Environment; Environmental Risk Factor; Exhibits; Exposure to; Face; Family; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; First Pregnancy Trimester; Frequencies; Funding; Hippocampus; Home; Human; Image; Impaired cognition; Income; Individual; Infant; Infrastructure; Intellectual functioning disability; Investigation; Knowledge; Life; Life Experience; Light; Longitudinal Studies; Maternal Age; Measures; Mediating; Medical; Mental Health; Morphology; Mothers; Nature; Outcome Measure; Participant; Patient Recruitments; Pattern; Perinatal; Population; Positioning Attribute; Poverty; Pregnancy; Prevalence; Problem behavior; Productivity; Prospective, cohort study; Publishing; Recording of previous events; Reporting; Research Design; Resources; Risk; Risk Factors; Sampling; Selection Criteria; Societies; South Africa; South African; Stress; Structure; Sudden infant death syndrome; Thick; Time; Tobacco use; Youth; alcohol exposure; binge drinking; cognitive development; cognitive function; cognitive testing; cohort; cost; drinking; drinking behavior; early childhood; early life adversity; environmental tobacco smoke exposure; experience; externalizing behavior; fetal tobacco exposure; girls; in utero; innovation; insight; low socioeconomic status; maternal alcohol use; maternal risk; neuroimaging; novel; nutrition; parity; perinatal period; postnatal; pregnant; prenatal; prospective; public health relevance; recruit; research study; resilience; social; stillbirth; substance use; toxicant; white matter

This is a competitive renewal application for R01-AA025653. Over the last 6 years, we have conducted neuroimaging studies in over 400 South African (SA) youth [8-12-years-old; ~300 with prenatal alcohol exposure (PAE) and ~100 non-exposed Controls (NC); 50% girls] from the Prenatal Alcohol, SIDS and Stillbirth (PASS) prospective birth cohort. The PASS cohort is comprised of ~6,000 SA children (born 2008- 2014; now ~8-15-years-old) whose mothers reported on drinking behavior during pregnancy. With pseudo- random selection criteria for the PAE participants recruited during the 1st funding period, the quantity of total drinks during pregnancy was (on average) quite low (range: ~1-611 drinks, M = 27.6, SD = 59.2 ). During this renewal period, we have the opportunity to extend recruitment to over-sample youth with much higher PAE quantities (range: ~32-817 drinks, M = 123.9, SD = 110.8). For renewal, we have developed a novel cohort- sequential cross-sectional/longitudinal study design, in which we would bring back ~50% of participants recruited during the 1st funding period (~150 PAE, ~50 NC) for longitudinal assessment of brain, cognition, and facial morphology (BCF), plus recruitment of ~250 new PASS participants (~200 PAE, ~50 NC). This will permit 1) recruitment of more highly exposed PAE participants to span the range of exposure, 2) study of a broader age range across adolescence among PAE and NC from 8 to 17 years during which dramatic brain development continues, and 3) utilization of data collected during the 1st 6 years both in the longitudinal component and with newly recruited participants in the cross-sectional component. Notably, most children with heavy PAE experience greater early life adversity than NC children, and early intervention is believed to be key in attenuating PAE-effects, the latter of which may depend, in part, on understanding the impact of quantity, frequency and timing (QFT) and early life experiences. Our history of productive team-work and existing infrastructure, coupled with experienced staff and collaborators in South Africa over the last 6 years, bode well for renewal, putting us in an exceptional position to further understanding how QFT of PAE independently, or interactively, impacts associations between (1) brain and cognition/behavior, (2) brain and early life environment, and (3) brain and facial morphology as function of environmental/maternal factors. We will use identical measures of brain structure/function, 3D facial imaging, cognition (WISC-V), early life experience (e.g., maternal age, nutrition, parity, mental health, substance use both perinatally and currently) and environmental risk factors (e.g., multiple measures of SES, access to resources, stress), measured perinatally and during childhood. Both cross-sectional and longitudinal quantitative measures from 3D facial imaging will be utilized in parallel with neuroimaging and cognitive assessments. Using the entire range of PAE, we expect independent and interactive (e.g., quantity by timing) effects of QFT on brain/cognition/face associations, with the largest effects driven by quantity, followed by frequency, and then timing of PAE.

这是R01-AA025653的竞争更新申请。在过去的六年中，我们进行了 在400多名南非（SA）青年[8-12岁； 〜300与产前酒精 暴露（PAE）和〜100个非暴露对照（NC）； 50％的女孩]来自产前酒精，小岛屿发展中国家和 死胎（通过）前瞻性出生队列。通行物队列由约6,000名SA儿童组成（生于2008年 - 2014;现在〜8-15岁）的母亲报告了怀孕期间的饮酒行为。伪 PAE参与者的随机选择标准在第一个资金期间招募，总数 怀孕期间的饮料（平均）很低（范围：〜1-611饮料，M = 27.6，SD = 59.2）。在此期间 更新时期，我们有机会将招聘扩展到更高的PAE的过度样本青年 数量（范围：〜32-817饮料，M = 123.9，SD = 110.8）。为了续订，我们已经开发了一个新颖的队列 顺序横断面/纵向研究设计，其中我们将带回约50％的参与者 在第一个资金期间（〜150 PAE，〜50 NC）招募，用于大脑，认知和 面部形态（BCF），加上〜250个新的通行证参与者（〜200 PAE，〜50 NC）的招聘。这会 允许1）招募更高度暴露的PAE参与者跨越暴露范围，2）研究 PAE和NC之间的青春期年龄范围从8到17岁，在此期间戏剧性的大脑 开发继续，3）在纵向中的第1六年中收集的数据的利用 组件以及新招募的横截面组件参与者。值得注意的是，大多数孩子 繁重的PAE比NC儿童经历更大的早期逆境，并且据信早期干预是关键 在衰减PAE效应时，后者可能部分取决于理解数量的影响 频率和时机（QFT）和早期生活经历。我们有效的团队合作的历史和现有 在过去6年中，基础设施以及南非的经验丰富的员工和合作者，Bode Well 为了续订，使我们处于一个非凡的立场，以进一步了解PAE的Qft是如何独立的，或 互动地影响（1）大脑与认知/行为之间的关联，（2）大脑和早期生活 环境和（3）大脑和面部形态作为环境/母体因素的功能。我们将使用 大脑结构/功能的相同度量，3D面部成像，认知（WISC-V），早期生活经验 （例如，孕产妇年龄，营养，奇偶校验，心理健康，目前的物质使用）和 环境风险因素（例如，SES的多种度量，获得资源，压力），围绕围产期测量 在童年时期。来自3D面部成像的横截面和纵向定量度量将会 与神经影像学和认知评估并行使用。我们希望使用整个PAE QFT对大脑/认知/面部关联的独立和互动（例如，数量）与 由数量驱动的最大效果，其次是频率，然后是PAE的时机。

项目成果

SrvfNet: A Generative Network for Unsupervised Multiple Diffeomorphic Functional Alignment.

• DOI: 10.1109/cvprw53098.2021.00505
• 发表时间: 2021-06
• 期刊: Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. Workshops
• 作者: Nunez, Elvis;Lizarraga, Andrew;Joshi, Shantanu H.
• 通讯作者: Joshi, Shantanu H.

Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective.

• DOI: 10.3389/fnint.2023.1104788
• 发表时间: 2023
• 期刊: FRONTIERS IN INTEGRATIVE NEUROSCIENCE
• 影响因子: 3.5
• 作者: Xia, Yingjing;Rebello, Vida;Bodison, Stefanie C.;Jonker, Deborah;Steigelmann, Babette;Donald, Kirsten A.;Charles, Weslin;Stein, Dan J.;Ipser, Jonathan;Ahmadi, Hedyeh;Kan, Eric;Sowell, Elizabeth R.;Narr, Katherine L.;Joshi, Shantanu H.;Odendaal, Hein J.;Uban, Kristina A.
• 通讯作者: Uban, Kristina A.