Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence

青春期大脑、神经认知和青春期成熟的成像

基本信息

批准号：
7984756
负责人：
ELIZABETH R SOWELL
金额：
$ 64.02万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-21 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7984756
关键词：
15 year old Address Adolescence Adolescent Adult Affect Affective Age Amygdaloid structure Animals Anisotropy Anxiety Behavior Behavioral Bilateral Brain Brain imaging Brain region Cell physiology Child Childhood Cognition Cognitive Competence Data Depressed mood Depression and Suicide Development Diffusion Magnetic Resonance Imaging Dissociation Dorsal Emotional Emotions Environmental Risk Factor Equilibrium Estrogens Face Face Processing Facial Expression Female Fiber Functional Imaging Functional Magnetic Resonance Imaging Gender Genetic Goals Gonadal Steroid Hormones Hand Hippocampus (Brain)Hormonal Hormones Human Hydrocortisone Image Analysis Impulsivity Individual Inferior Knowledge Lateral Left Literature Magnetic Resonance Imaging Maps Measures Medial Mediating Mediation Mental Health Mental disorders Modeling Motivation Multimodal Imaging NIH Program Announcements National Institute of Mental Health Neurocognitive Neurosecretory Systems Occipital lobe Outcome Parietal Lobe Participant Pattern Performance Phase Prefrontal Cortex Process Psychopathology Puberty Radial Relative (related person)Reporting Research Research Personnel Rewards Risk Risk Assessment Saliva Sampling Scanning Sex Characteristics Sexual Maturation Signal Transduction Social Change Social Functioning Social Interaction Staging Stress Structure Study Subject Substance abuse problem Synapses System Task Performances Temporal Lobe Testing Testosterone Thick Time Visual Work Youth age effect age related analog area striata association cortex base behavior test boys brain behavior cognitive control cognitive function dehydroepiandrosterone density diaries discount discounting executive function frontal lobe functional status girls gray matter improved indexing interest male multidisciplinary myelination neurocognitive test neuroimaging public health relevance relating to nervous system response reward processing sex standardize measure white matter

项目摘要

DESCRIPTION (provided by applicant): Enormous progress has been made recently in understanding the age-related structural maturational changes that occur in the human brain during childhood and adolescence, but variability in brain structure is very large, even among individuals of the same chronological age. The literature suggests an offset in development of limbic structures which control affect, emotion, encoding information, which may develop prior to the executive centers (frontal cortices) that provide regulatory control over impulses and risk assessment. Almost nothing is yet known about neurodevelopmental, neuroendocrine, behavioral and environmental factors that likely relate to variability in brain structure and function, and cognitive abilities that change so dramatically during adolescence. In this project, we propose to longitudinally study 120 typically developing adolescents between 9 and 15 years of age with 2-year scan intervals, and to collect brain imaging (structural MRI, diffusion tensor imaging and functional MRI with tasks of response inhibition, reward processing, delayed discounting, facial affect processing), neurocognitive (with emphasis on executive functioning and cognitive control), physical sexual maturation (using Tanners staging), and hormonal (cortisol, testosterone, estrogen and Dehydroepiandrosterone (DHEA) using saliva samples) data as well as measures of daily stress. With these rich multimodal imaging, behavioral, cognitive and hormonal data, we will address the following specific aims: 1) to distinguish hormone-dependent from non-hormone dependent neurodevelopmental effects in adolescence, 2) to evaluate relationships between brain changes and behavioral indices of cognition (cognitive control, executive functions, daily stress) and motivation (e.g., reward sensitivity), and 3) to evaluate gender differences in relationships between brain changes and indices of pubertal progression. To our knowledge, this will be the first study to undertake such challenges by using cutting-edge integrative multimodal image analyses of functional and structural MRI to examine, longitudinally, brain development in adolescents and to distinguish hormonal from other age-related environmental and behavioral correlates. PUBLIC HEALTH RELEVANCE: The proposed research to study adolescent brain development using integrated multimodal neuroimaging, neurocognitive, stress, and hormonal measures longitudinally in typically developing children and adolescents is of the utmost importance. The beginning of adolescence is a time of dramatic physical, emotional and social change, and is also associated with the onset of psychopathology such as depression, suicide, and substance abuse. To provide a framework for understanding how risks during adolescence can tip the balance toward pathological outcomes in youth and adulthood, models of typical brain development need to evaluate interactions between hormonal and physical sexual maturity and the still-maturing neural systems responsible for social interactions, affective states and cognitive control.

描述（由申请人提供）：最近在理解人类大脑在儿童期和青春期发生的与年龄相关的结构成熟变化方面取得了巨大进展，但大脑结构的变异性非常大，即使在相同年龄的个体之间也是如此。文献表明，控制情感、情绪、编码信息的边缘结构的发育存在偏差，这些结构可能先于执行中心（额叶皮层）发育，而执行中心对冲动和风险评估提供调节控制。对于神经发育、神经内分泌、行为和环境因素几乎一无所知，这些因素可能与青春期期间发生巨大变化的大脑结构和功能以及认知能力的变异性有关。在这个项目中，我们建议对 120 名 9 至 15 岁之间的典型发育青少年进行纵向研究，扫描间隔为 2 年，并收集脑成像（结构 MRI、扩散张量成像和功能 MRI，任务包括反应抑制、奖励处理）、延迟折扣、面部情感处理）、神经认知（重点是执行功能和认知控制）、身体性成熟（使用 Tanners 分期）和激素（皮质醇、睾酮、雌激素和脱氢表雄酮 (DHEA)（使用唾液样本）数据以及日常压力测量。借助这些丰富的多模态成像、行为、认知和激素数据，我们将实现以下具体目标：1）区分青春期激素依赖性和非激素依赖性神经发育效应，2）评估大脑变化和行为指标之间的关系认知（认知控制、执行功能、日常压力）和动机（例如奖励敏感性），3）评估大脑变化和青春期进展指数之间关系的性别差异。据我们所知，这将是第一项应对此类挑战的研究，通过使用功能和结构 MRI 的尖端综合多模态图像分析来纵向检查青少年的大脑发育，并将激素与其他与年龄相关的环境和行为相关因素区分开来。。公共健康相关性：拟议的研究使用综合多模式神经影像、神经认知、压力和激素测量来纵向研究典型发育儿童和青少年的青少年大脑发育是至关重要的。青春期的开始是身体、情感和社会发生巨大变化的时期，也与抑郁、自杀和药物滥用等精神病理学的发生有关。为了提供一个框架来理解青春期风险如何使青年期和成年期的病理结果转向平衡，典型的大脑发育模型需要评估荷尔蒙和身体性成熟以及负责社会互动、情感和情感的尚在成熟的神经系统之间的相互作用。状态和认知控制。