Dopaminergic Function in Alcoholism

酒精中毒中的多巴胺能功能

基本信息

批准号：
7803679
负责人：
DAVID A. KAREKEN
金额：
$ 57.79万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-15 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7803679
关键词：
Alcohol abuse Alcohol consumption Alcoholic Beverages Alcoholic Intoxication Alcoholism Alcohols Animal Model Animals Behavioral Paradigm Biological Markers Brain Cells Chemicals Conditioned Stimulus Consumption Corpus striatum structure Cues Data Dependence Development Diagnosis Dopamine Environment Esthesia Ethanol Exposure to Functional Magnetic Resonance Imaging Goals Human Image Incentives Indiana Infusion procedures Intoxication Intravenous Laboratories Lead Learning Ligands Link Measurement Methods Midbrain structure Modeling Neurons Nucleus Accumbens Odors Oral Positron-Emission Tomography Proxy Raclopride Recording of previous events Relapse Relative (related person)Research Research Personnel Rewards Risk Rodent Rodent Model Role Scientist Self Administration Smell Perception Stimulus System Taste Perception Technology Testing Translating Translations Universities Ventral Striatum Ventral Tegmental Area Vision Visual Work Workplace addiction alcohol availability alcohol cue alcohol effect alcohol exposure alcohol research alcohol response alcohol reward alcohol use disorder analog approach behavior blood oxygen level dependent computerized craving cue reactivity dopaminergic neuron drinking expectation experience hemodynamics human subject in vivo knowledge translation learning extinction multidisciplinary neurochemistry neuroimaging neurotransmission novel oral sensory problem drinker public health relevance research study response success transmission process

项目摘要

DESCRIPTION (provided by applicant): Dopaminergic transmission in the brain's mesocorticolimbic system is thought to be a significant factor in alcohol abuse and dependence. Most research on the dopaminergic response to alcohol and its conditioned cues is nevertheless done in rodents. The extent to which these rodent models translate to human alcohol use disorders is unknown. Therefore the long term goal of our proposed work is the development of an in vivo human biomarker of striatal dopaminergic responses that can be applied to the study alcoholism and its antecedent risks. We will do this using positron emission tomography (PET) and the dopamine D2 ligand [11C]raclopride. Behavioral paradigms will be employed to study how alcohol administration, alcohol's cues, and expectations of impending alcohol-intoxication relate to dopamine function in subjects with alcoholism. PUBLIC HEALTH RELEVANCE: This research will use a technology called positron emission tomography to study the neurochemical dopamine in the human brain. Alterations in this neurochemical system are thought to be highly important to alcoholism, as well as to other addictions. Research such as this has the potential to show exactly how dopamine neurotransmission is altered in alcoholism, findings that may lead to better treatments and diagnosis.

描述（由申请人提供）：脑中皮质降低系统中的多巴胺能传播被认为是酒精滥用和依赖性的重要因素。大多数关于对酒精及其条件提示的多巴胺能反应的研究是在啮齿动物中进行的。这些啮齿动物模型转化为人类酒精使用障碍的程度尚不清楚。因此，我们提出的工作的长期目标是开发纹状体多巴胺能反应的体内人类生物标志物，可以应用于研究酒精中毒及其先前风险。我们将使用正电子发射断层扫描（PET）和多巴胺D2配体[11C] raclopride来做到这一点。将采用行为范例来研究饮酒，酒精提示以及对酒精中毒的期望与酒精中毒受试者的多巴胺功能有关。公共卫生相关性：这项研究将使用一种称为正电子发射断层扫描的技术来研究人脑中的神经化学多巴胺。该神经化学系统的改变被认为对酒精中毒以及其他成瘾非常重要。诸如此类的研究有可能准确地展示酗酒中多巴胺神经传递的改变，这可能会导致更好的治疗和诊断。