Dopaminergic Function in Alcoholism

酒精中毒中的多巴胺能功能

• 批准号: 8451447
• 负责人: DAVID A. KAREKEN
• 金额: $ 35.25万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-15 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8451447
• 关键词: Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Alcohols; Animal Model; Animals; Behavioral Paradigm; Biological Markers; Brain; Cells; Chemicals; Conditioned Stimulus; Consumption; Corpus striatum structure; Cues; Data; Development; Diagnosis; Dopamine; Environment; Esthesia; Ethanol; Exposure to; Functional Magnetic Resonance Imaging; Goals; Health; Human; Image; Incentives; Indiana; Infusion procedures; Intoxication; Intravenous; Laboratories; Lead; Learning; Ligands; Link; Measurement; Methods; Midbrain structure; Modeling; Neurons; Nucleus Accumbens; Odors; Oral; Positron-Emission Tomography; Proxy; Raclopride; Recording of previous events; Relapse; Relative (related person); Research; Research Personnel; Rewards; Risk; Rodent; Rodent Model; Role; Scientist; Self Administration; Smell Perception; Stimulus; System; Taste Perception; Technology; Testing; Translating; Translations; Universities; Ventral Striatum; Ventral Tegmental Area; Vision; Visual; Work; addiction; alcohol availability; alcohol cue; alcohol effect; alcohol exposure; alcohol research; alcohol response; alcohol reward; alcohol use disorder; analog; approach behavior; blood oxygen level dependent; computerized; craving; cue reactivity; dopaminergic neuron; drinking; expectation; experience; hemodynamics; human subject; in vivo; knowledge translation; learning extinction; multidisciplinary; neurochemistry; neuroimaging; neurotransmission; novel; oral sensory; problem drinker; research study; response; success; transmission process

DESCRIPTION (provided by applicant): Dopaminergic transmission in the brain's mesocorticolimbic system is thought to be a significant factor in alcohol abuse and dependence. Most research on the dopaminergic response to alcohol and its conditioned cues is nevertheless done in rodents. The extent to which these rodent models translate to human alcohol use disorders is unknown. Therefore the long term goal of our proposed work is the development of an in vivo human biomarker of striatal dopaminergic responses that can be applied to the study alcoholism and its antecedent risks. We will do this using positron emission tomography (PET) and the dopamine D2 ligand [11C]raclopride. Behavioral paradigms will be employed to study how alcohol administration, alcohol's cues, and expectations of impending alcohol-intoxication relate to dopamine function in subjects with alcoholism.

描述（由申请人提供）：大脑中皮质边缘系统中的多巴胺能传递被认为是酒精滥用和依赖的一个重要因素。然而，大多数关于酒精及其条件信号的多巴胺能反应的研究都是在啮齿动物身上进行的。这些啮齿动物模型在多大程度上转化为人类酒精使用障碍尚不清楚。因此，我们提出的工作的长期目标是开发一种纹状体多巴胺能反应的体内人类生物标志物，可应用于酒精中毒及其先行风险的研究。我们将使用正电子发射断层扫描 (PET) 和多巴胺 D2 配体 [11C]雷氯必利来完成此操作。将采用行为范式来研究酒精中毒受试者的饮酒、酒精暗示和对即将发生酒精中毒的预期与多巴胺功能的关系。