Botanical/Plant Genomics Core/Wendy Applequist

植物学/植物基因组学核心/Wendy Applequist

• 批准号: 8007170
• 负责人: DENNIS B LUBAHN
• 金额: $ 4.36万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007170
• 关键词: American; Analytical Chemistry; Area; Botanicals; Breeding; Chemicals; Clinical Trials; Collection; Development; Elderberry; Ensure; Fertilization; Fruit; Future; Genetic; Genistein; Genomics; Genotype; Goals; Guidelines; Human Resources; Isoflavones; Lead; Materials Testing; Methods; Monitor; Nitrogen; Phytosterols; Plants; Population; Production; Relative (related person); Research; Research Personnel; Research Project Grants; Sampling; Sampling Studies; Screening procedure; Services; Source; Soybeans; Specimen; Surveys; Variant; Work; acetovanillone; base; dietary supplements; interest; plant genetics; soy; voucher; working group

The Botanicals/Plant Genomics Core will support the Research Projects by supplying some botanical test materials, ensuring that identity and quality of botanical materials are properiy documented, and supplying samples for studies of infraspecific variation in species studied. Specific aims include (1) identifying, documenting, and supplying botanical raw materials; (2) collecting, cultivating, and supplying elderberry accessions for studies of infraspecific variation; (3) collecting, cultivating, and supplying plant materials for apocynin screening; and (4) conducting plant genetic studies in soybean to elucidate the extent and genetic basis of variation in the level of bioactive compounds. The Botanicals Core will identify and preserve voucher samples of all materials obtained as raw botanicals, including herbarium specimens to voucher samples collected by the Core. Elderberry and soy germplasm collections are already available, from which botanical test materials of desirable chemical composition will be supplied. Field work will be done to obtain more elderberry genotypes, and a horticultural study to determine the effect of nitrogen fertilization on chemical content will be performed. Native North American botanicals that might contain apocynin will be surveyed in an effort to locate a reliably obtainable, easily cultivated source of that compound. A soybean breeding study will identify genotypes associated with high and low levels of compounds of interest. These studies will further the characterization of test materials used by the Research Projects and enhance the interpretation of their results relative to the broader universe of variation within those species. Additionally, they will facilitate the longer-term goals of selecting high-potency materials for future studies, including clinical trials, and superior genotypes for use in developing alternative crops.

植物/植物基因组学核心将通过提供一些植物测试材料来支持研究项目，以确保对植物材料的身份和质量进行了适当的记录，并为研究物种中的基本变异提供了样本。具体目的包括（1）识别，记录和提供植物原材料； （2）收集，培养和供应接骨木浆果以进行炎症研究； （3）收集，培养和供应植物材料以筛选apocynin筛查； （4）在大豆进行植物遗传研究以阐明生物活性化合物水平变异的程度和遗传基础。植物核心将识别并保留所有作为原始植物的材料的代金券样品，包括核心收集的代金券样本的标本式标本。接骨木浆果和大豆种质收集已经可用，将提供所需的化学成分的植物测试材料。将进行现场工作以获得更多的接骨木基因型，并进行园艺研究，以确定氮肥对化学含量的影响。可能会调查可能包含apocynin的北美植物植物，以找到可靠的可靠，易于培养的该化合物来源。一项大豆育种研究将鉴定与感兴趣的高水平和低水平化合物相关的基因型。这些研究将进一步表征研究项目使用的测试材料，并增强其结果相对于这些物种内部较广泛的变化宇宙的解释。此外，它们将促进为将来的研究选择高效材料的长期目标，包括临床试验，以及用于开发替代作物的优质基因型。