Scientific Core

科学核心

• 批准号: 7813638
• 负责人: AMELIA M ARRIA
• 金额: $ 55.03万
• 依托单位: TREATMENT RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7813638
• 关键词: Americas; Center for Translational Science Activities; Charge; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Communication Research; Confidentiality of Patient Information; Data; Decision Making; Environment; Fostering; Generic Drugs; Goals; Intervention; Interviewer; Knowledge; Mentors; Methods; Monitor; Parents; Participant; Pennsylvania; Pharmaceutical Preparations; Pilot Projects; Procedures; Process; Public Health; Publications; Research; Research Ethics; Research Ethics Committees; Research Institute; Research Personnel; Research Project Grants; Resources; Safety; Scientist; Services; Structure; Training; Translating; Universities; Work; addiction; adolescent substance abuse; career; data integrity; data management; data sharing; design; evidence base; follow-up; operation; tool

The Scientific Core of the proposed Parents' Translational Research Center will coordinate the research needs ofthe three Core projects and pilot studies. The overall aims ofthe Scientific Core are to: 1) Manage the collecfion, processing, analysis and publication of data emanating from the studies in an efficient manner; 2) Maintain the highest level of research ethics, data integrity and methodological standards for all activities; and 3) Incorporate communications expertise to translate our findings into useful, evidence-based tools for parents and other consumers. Within the Core, the day-to-day management ofthe research, communication, training and mentoring functions will be served by a weekly Center Management Team consisting of Drs. McLellan (Center Director), Winters (Associate Center Director), Arria (Scientific Director), Ms. Faranda Diedrich (Coordinator); and Mr. Pasierb (CEO, The Partnership for Drug Free America). The Center Management Team will facilitate planning, coordinafion, and Implementafion of the research projects, plan analyses and promote collaboration. This core will use the existing Data Management Unit, as well as the IRB and Data Safety and Monitoring Board (DSMB) already funcfioning within the Treatment Research Institute (TRI). The Scientific Core will provide important core services to all projects and investigators (Scientific Decision Making, Scientific Review and Guidance, Study Coordination, Data Management, and Data Sharing with Other Centers). Initial training of all research assistants, coordinators and investigators will be a key responsibility of the Scientific Core, providing standardized, center-wide training in four generic research procedures necessary for efficient operation of all Center studies (interviewer training, participant recruitment, assurance of participant safety and confidentiality, and patient tracking and follow-up). Mentoring of New Investigators will be managed by a specially appointed Director of Training and Mentoring (Dr. Kirby) who will be charged with monitoring and fostering the developing careers of fellows and new scientists within the Center. Finally, the Scientific Core (with its Advisory Boards) will be responsible for selecting and managing two pilot projects each year, using a review process that encourages work by New Investigators.

拟议的家长转化研究中心的科学核心将协调 三个核心项目和试点研究的研究需求。科学核心的总体目标是： 1）管理研究数据的收集、处理、分析和发布 高效的方式； 2) 为所有人保持最高水平的研究道德、数据完整性和方法标准 活动;和 3）结合传播专业知识，将我们的发现转化为有用的、基于证据的工具 父母和其他消费者。 在核心内部，研究、沟通、培训和管理的日常管理 指导职能将由每周由博士组成的中心管理团队提供。麦克莱伦 （中心主任）、Winters（中心副主任）、Arria（科学主任）、Faranda Diedrich 女士 （协调员）； Pasierb 先生（美国无毒伙伴关系首席执行官）。中心管理 团队将促进研究项目的规划、协调和实施、计划分析和 促进合作。该核心将使用现有的数据管理单元以及 IRB 和数据 安全和监测委员会 (DSMB) 已在治疗研究所 (TRI) 内运作。 科学核心将为所有项目和研究者提供重要的核心服务（科学 决策、科学审查和指导、研究协调、数据管理和数据共享 与其他中心）。所有研究助理、协调员和研究人员的初步培训将是关键 科学核心的职责，为所有中心研究的有效运作所必需的四个通用研究程序提供标准化的全中心培训（访谈员培训、参与者招募、保证参与者的安全和保密以及患者跟踪和随访）。 新研究者的指导将由特别任命的培训和指导主任（Kirby 博士）管理，他将负责监督和促进中心内研究员和新科学家的职业发展。 最后，科学核心（及其咨询委员会）将负责每年选择和管理两个试点项目，采用鼓励新研究者工作的审查流程。