Preclinical Assessment Core (PAC)

临床前评估核心 (PAC)

基本信息

批准号：
10714166
负责人：
Jeryl Jones
金额：
$ 17.66万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10714166
关键词：
Accreditation Address Anatomy Animal Model Animals Attention Autopsy Awareness Biochemistry Biological Markers Biomedical Engineering Biomedical Research Bone Diseases Budgets Cadaver Caring Center for Translational Science Activities Centers of Research Excellence Charge Clinic Clinical Collaborations Computer Models Consultations Core Facility Development Devices Diagnostic Procedure Effectiveness Evaluation Experimental Designs Farm Foundations Future Goals Harvest Health Health system Human Human Resources Image Analysis Implant In Vitro Laboratories Leadership Location Logistics Medicine Mentors Methodology Methods Mission Modeling Musculoskeletal Operative Surgical Procedures Optics Orthopedics Patient Care Patients Phase Physical therapy Pre-Clinical Model Process Protocols documentation Research Research Design Research Personnel Resources Role Safety Sampling Studies Scientist Services South Carolina Speed Sports Medicine Strategic Planning Support Groups Surgeon Technology Testing Tissue Procurements Tissue Sample Training Training Programs Translational Research Travel Universities animal care animal imaging arthropathies bench to bedside clinical practice clinically relevant diagnostic strategy experimental study flexibility histotechnology human tissue imaging facilities implantation improved in vivo innovation invention model design new technology novel pre-clinical assessment pre-clinical research preservation programs service organization skills stem cells technology development virtual human

项目摘要

SUMMARY A major purpose of the COBRE South Carolina Center for Translational Research for Improving Musculoskeletal Health (SC-TRIMH) is to promote and enable research and innovation addressing bone and joint disorders for the improvement of patient care. Animal models and human cadaveric models are essential for verifying musculoskeletal research hypotheses, and are intrinsic to the pre-clinical assessment strategy for diagnostics and treatments, for novel technology evaluation, and for the verification of computational models. The mission of the Pre-clinical Assessment Core (PAC) is to provide mentoring and strategic planning to SC-TRIMH investigators for the use of live large animal models and/or human cadaver models in their musculoskeletal research programs. It provides the specialized facilities, expertise, and resources needed by SC-TRIMH investigators to further evaluate the potential of their in vitro advances into clinical practice. In COBRE Phase I, PAC has consolidated unique resources and expertise at Clemson University and the PRISMA Health System (PHS) into a comprehensive network of experts and services organized into two complementary thrusts: the Live Animal Modeling (LAM) and Human Cadaveric Modeling (HCM) thrusts. LAM includes state-of-art biomedical research and animal imaging facilities at the AAALAC-accredited Godley-Snell Research Center and the Clemson Farms enabling access to the full spectrum of animal models used in musculoskeletal research as well as flexibility for the development of novel models needed by SC-TRIMH investigators. Over the years, Clemson University, through its Bioengineering Department, has built an impressive portfolio of musculoskeletal innovative research using large animal models which laid the foundation for PAC capabilities in Phase I. The HCM thrust, located at the Clemson University Biomedical Engineering Innovation Campus (CUBEInC), includes the Bioskills Surgical Training and Innovation Center and other resources. As the health innovation hub for Clemson University since 2011, CUBEInC is located at the PRISMA Health System above orthopaedic patient clinics and physical therapy. In Phase I, PAC integrated into its training program, the CUBEInC's resources and expertise in technology development and maturation, as well as start-up company development and mentoring, further increasing awareness of SC-TRIMH investigators about the innovation cycle. The PAC leadership team consists of the thrusts' co-directors, both renowned clinicians and scientists, and a support group of facility managers, technical experts, and scientists. In Phase II, PAC will continue to provide technical mentoring and support to all SC-TRIMH investigators, especially those who do not have primary expertise in pre-clinical assessment, while progressing toward being the major translational resource for musculoskeletal researchers from across South Carolina and elsewhere. The specific aims of PAC are to 1) continue providing expertise and support for pre- clinical modeling, 2) continue serving as a facilitator for junior investigator pre-clinical research, and 3) further strengthen and enhance the in vivo and ex vivo pre-clinical research capability to support SC-TRIMH.

概括南卡罗来纳州索布尔转化研究中心的主要目的是改善肌肉骨骼健康（SC-TRIMH）旨在促进和启用研究和创新，以解决骨骼和关节疾病改善患者护理。动物模型和人类尸体模型对于验证至关重要肌肉骨骼研究假设，并且是诊断前临床前评估策略的固有的和治疗，用于新型技术评估以及计算模型的验证。任务临床前评估核心（PAC）是为SC-Trimh提供指导和战略计划研究人员在其肌肉骨骼中使用活的大型动物模型和/或人类尸体模型研究计划。它提供了SC-Trimh所需的专业设施，专业知识和资源研究人员进一步评估其体外进步在临床实践中的潜力。在第一阶段， PAC在克莱姆森大学和Prisma卫生系统中巩固了独特的资源和专业知识（PHS）进入一个综合的专家和服务网络，分为两个互补的推力：直播动物建模（LAM）和人尸体建模（HCM）推力。林包括最先进的生物医学 AAALAC认可的Godley-Snell研究中心的研究和动物成像设施和克莱姆森农场还可以进入肌肉骨骼研究中使用的全部动物模型作为SC-Trimh研究人员所需的新型模型的灵活性。多年来，克莱姆森大学通过其生物工程系建立了令人印象深刻的肌肉骨骼创新组合使用大型动物模型进行研究，这些模型为第一阶段的PAC能力奠定了基础。HCM推力，位于克莱姆森大学生物医学工程创新校园（Cubeinc），包括Bioskills 外科培训和创新中心以及其他资源。作为克莱姆森的健康创新中心自2011年以来，Cubeinc就位于骨科患者诊所上方的Prisma卫生系统中物理疗法。在第一阶段，PAC集成了其培训计划，Cube的资源和专业知识在技术开发和成熟以及启动公司开发和指导方面，进一步提高了SC-Trimh研究人员对创新周期的认识。 PAC领导团队组成推力联合导演，包括著名的临床医生和科学家，以及设施经理的支持小组，技术专家和科学家。在第二阶段，PAC将继续为所有人提供技术指导和支持 SC-TRIMH调查人员，尤其是那些没有临床前评估专业知识的人，而朝着成为南方肌肉骨骼研究人员的主要转化资源迈进卡罗来纳州和其他地方。 PAC的具体目的是1）继续提供专业知识和支持临床建模，2）继续担任初级研究员临床前研究的促进者，3）进一步增强和增强体内和外体临床前研究能力，以支持SC-TRIMH。