Request for High-Resolution Peripheral Quantitative Computed Tomography

要求高分辨率外围定量计算机断层扫描

• 批准号: 8947459
• 负责人: DENNIS T. VILLAREAL
• 金额: --
• 依托单位: MICHAEL E DEBAKEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8947459
• 关键词: 3-Dimensional; Acceleration; Address; Affect; Back; Biological Markers; Bone Density; Bone Mineral Contents; CYP19A1 gene; Calibration; Caring; Center for Translational Science Activities; Charge; Clinical; Collaborations; Computer software; Computers; Core Facility; Coupled; Densitometry; Diabetes Mellitus; Disease; Distal; Doctor of Philosophy; Ensure; Equipment; Fatty acid glycerol esters; Fees; Finite Element Analysis; Fostering; Foundations; Funding; Generations; Goals; Health Priorities; Healthcare; Heart failure; Human; Hypogonadism; Image; Image Analysis; Inflammatory; Interdisciplinary Study; Intervention; Laboratories; Leadership; Life Style; Lifestyle Therapy; Maintenance; Malignant Neoplasms; Measures; Medical; Medical center; Metabolic; Metabolic Bone Diseases; Methods; Minor; Modeling; Monitor; Muscle; Obesity; Osteoporosis; Outcome; Parkinson Disease; Patients; Peripheral; Pharmacogenetics; Physicians; Porosity; Preventive; Property; Radial; Radiation; Recruitment Activity; Request for Applications; Research; Research Personnel; Research Project Grants; Resolution; Role; Scanning; Scientist; Software Tools; Speed; Staging; Structure; Syndrome; System; Testosterone; Thick; Time; Traumatic Brain Injury; Tube; Veterans; Walking; Weight; X-Ray Computed Tomography; base; benefit sharing; bone; bone metabolism; bone quality; bone strength; calcification; cancer cachexia; career development; density; design; detector; evidence base; experience; follow-up; ghrelin; in vivo; innovation; interest; investigator training; morphometry; novel; novel strategies; operation; programs; public health relevance; reconstruction; research and development; response; tibia

 DESCRIPTION (provided by applicant): The present application is in response to Request for Application Number: BX-14-015 (ORD Shared Equipment Program [ISI]). The purpose is to make available to the Michael E DeBakey VA Medical Center (MEDVAMC) a high resolution peripheral quantitative computed tomography (HR-pQCT), as shared equipment and expand multiple VA funded veteran-centric research projects. The HR-pQCT is a non-invasive, low-radiation method that provides an unprecedented ability to measure three-dimensional (3-D) human bone microarchitecture and volumetric bone mineral density (vBMD) in vivo. Coupled with computer-based finite element analyses (FEA) modeling, the HR-pQCT also provides a novel approach to noninvasively assess bone strength. The HR-pQCT will be the Xtreme CTII (Scanco USA, Inc, Southeastern, PA), the new generation HR-pQCT, designed to quantify the 3-D microarchitecture of bone and vBMD at even higher precision and speed than its predecessor, the Xtreme CT. The system is particularly suited to assess and monitor treatment (e.g. response to lifestyle and pharmacologic interventions) of metabolic bone diseases and other inflammatory conditions such as diabetes, obesity, and cancer. The research projects to be significantly benefited by the shared HR-pQCT equipment will include 4 Merit Review (101 CX000906: "Testosterone Replacement to Augment Lifestyle Therapy in Obese Older Veterans; 101 CX000424: "CYP19A1 Gene and Pharmacogenetics of Response to Testosterone Therapy"; 101 CX000174: "The Role of Ghrelin in Cancer Cachexia"; 101CXS001112: "Biomarker Guided Therapies in Stage A/B Heart Failure") and 1 Career Development (IK2 TX000734: "Multidirectional Treadmill Walking in Parkinson Disease") VA-supported projects from 5 "major" 8/8th VA salaried users (Dennis T. Villareal, MD, Reina C. Villareal, MD, Jose Garcia, MD, PhD, Vijay Nambi, MD, Monthaporn Bryant PT, PhD) and 4 research projects from several "minor" users (e.g. DOD, foundation-supported projects). Thus, the spectrum of priority-health problems addressed by these VA-centric research projects are varied (obesity, metabolic bone disorders, hypogonadism, heart failure, cancer, traumatic brain injury, etc.), ensuring maximum and efficient utilization of shared equipment for the acceleration of research progress and improvement of veteran care. Multiple MEDVAMC investigators can immediately add novel outcomes such as bone microarchitecture and vBMD to ongoing VA funded research, which will significantly impact the advancement of health care of veterans. The HR-pQCT Core Facility will be directed by Dr. Dennis T. Villareal, a VA Physician-Scientist with leadership experience and research expertise that includes Bone metabolism and Clinical Densitometry. The HR-pQCT Core Facility will be integrated within the Imaging Core Facility of our internally-funded Center for Translational Research on Inflammatory Disease (CTRID) at MEDVAMC. The CTRID has recently recruited a full time laboratory manager who will have primary responsibility for assisting with the operation of the equipment, training of investigators on equipment use, managing of equipment access, and coordinating of collaborative research. A modest charge back fee for funded investigators will supplement the financial plan for long-term operation and management of the equipment. The CTRID will continue to host weekly research seminars to discuss research progress and plan research grant applications that capitalize on the novel applications of the HR-pQCT. The facility director and R&D committee fully endorse this application, including support for long-term preventive maintenance of the equipment. The broad, long-term objectives of the HR-pQCT shared equipment are to build the research capabilities of MEDVAMC, foster collaborative interdisciplinary research among MEDVAMC investigators, recruit new VA researchers to MEDVAMC, and create innovations that advance the health care for our veterans and the nation, consistent with VAMC's long term research goals.

 描述（申请提供）：本申请响应申请编号的请求：BX-14-015（ORD共享设备程序[ISI]）。目的是向Michael E DeBakey VA医疗中心（MEDVAMC）提供高分辨率外围定量计算机断层扫描（HR-PQCT），作为共享设备并扩展了多个VA资助 以资深人士为中心的研究项目。 HR-PQCT是一种非侵入性的低辐射方法，可在体内测量三维（3-D）人骨微体系结构和体积骨矿物质密度（VBMD）的前所未有的能力。加上基于计算机的有限元分析（FEA）建模，HR-PQCT还提供了一种新颖的方法来非侵入性地评估骨强度。 HR-PQCT将是新一代HR-PQCT的Xtreme CTII（Scanco USA，Inc.，Sover USA，Inc。），旨在量化骨和VBMD的3-D微体系结构，其精度和速度比其前辈更高的精度和速度量化。该系统特别适合代谢骨疾病的评估和监测治疗（例如对生活方式和药物干预的反应）以及其他炎症性疾病，例如糖尿病，肥胖和癌症。共享的HR-PQCT设备将大大受益的研究项目将包括4个优点审查（101 CX000906：“睾丸激素更换为肥胖老年退伍军人的增强生活方式疗法； 101 CX000424： “ CYP19A1基因和对睾丸激素治疗的反应的药物学”； 101 CX000174：“生长素素在癌症恶病质中的作用”； 101CXS001112：“生物标志物在A/B期心衰竭中指导疗法”）和1个职业发展（IK2 TX000734：“在帕金森病中行走的多向跑步机”）VA支持的项目来自5“ Major” 8/8 va salaried salarieed用户（DENNIS）T。villareal t. villareal c. villareal c. villareal，Mdeac，Mdeac，Mdeac，Mdeac，Mdeac，Mdeac，Mdeac，Mdeace，Mdeace，Mdeace，Mdece graine g。博士学位，维杰·纳比（Vijay Nambi），医学博士，Monteraporn Bryant PT，PhD）和来自几个“次要”用户的4个研究项目（例如，国防部，基础支持的项目）。那， 这些以VA为中心的研究项目解决的优先健康问题的范围是多种多样的（肥胖，代谢骨骼疾病，性腺功能障碍，心力衰竭，癌症，脑部损伤等），可确保对共享设备的最大程度地利用共享设备来加速兽医护理的研究进度和改进。多个MEDVAMC调查人员可以立即在正在进行的VA资助研究中添加新的结果，例如骨微结构和VBMD，这将显着影响退伍军人医疗保健的进步。 HR-PQCT核心设施将由VA医师科学家Dennis T. Villareal博士指导，具有领导经验和研究专业知识，其中包括骨骼代谢和临床模式。 HR-PQCT核心设施 将集成在MEDVAMC的内部资助转化研究中心（CTRID）的成像核心设施中。 CTRID最近招募了一名全职实验室经理，该经理将对设备进行操作，调查人员进行设备使用，设备访问的管理以及协调协作研究的主要责任。资金调查人员的适度收费费将补充用于设备的长期运营和管理的财务计划。 ctrid 将继续主持每周的研究中心，以讨论研究进度并计划研究赠款的应用，以利用HR-PQCT的新应用。设施主任和研发委员会充分认可了此申请，包括支持对设备的长期预防性维护。 HR-PQCT共享设备的广泛，长期目标是建立MEDVAMC的研究能力，促进MEDVAMC研究人员之间的协作协作跨学科研究，招募新的VA研究人员来MEDVAMC，并创造创新的创新，从而促进我们的退伍军人和国家的医疗保健，并符合VAMC的长期研究目标。