Johns Hopkins PKD Research and Clinical Core Center

约翰霍普金斯大学 PKD 研究和临床核心中心

• 批准号: 8049452
• 负责人: Terry J Watnick
• 金额: $ 120.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8049452
• 关键词: Johns; Hopkins; PKD; Research; Clinical

DESCRIPTION, OVERALL (provided by applicant): In this proposal we will establish The Johns Hopkins PKD Research and Clinical Core Center (JH-PKD Center), which will provide unique resources and expertise to a national and international Research Base. The Center capitalizes on a long tradition of PKD research at Johns Hopkins and on our unique status as a comprehensive PKD center. The goals of the center are 1) To provide state of the art reagents and expertise to a national and international group of investigators in order to facilitate PKD related research, 2) To provide reagents and expertise to non-PKD investigators in order to remove barriers to PKD related research, 3) To continue to support a vibrant PKD research community that will lead to collaborative interactions between investigators, 4) To establish enrichment activities that encourage open and critical thought and yield creative approaches to research questions, 5) To provide Pilot and Feasibility Funds to junior investigators, to support innovative lines of inquiry and to recruit new expertise to the PKD field and 6) To partner with other PKD Centers and the NIDDK to ensure that resources are used efficiently with a goal of stimulating Translational PKD Research. The JH-PKD Center will contain an Administrative Core (Core A) and 4 biomedical core resources including 1) Antibody Validation and Vectorology (Core B), 2) Mouse models and Biobank (Core C) 3) Cell Engineering (Core D) and 4) the Clinical and Translational Core Resource (Core E). Pilot studies chosen for the first year are tightly focused around Core resources and recruit 3 new investigators at different career stages to the PKD field. Pilot 1 will examine Racial Disparities in Attitudes towards Screening, Treatment, and Participation in Clinical Research for PKD. Pilot 2 will apply cutting edge molecular tools for live cell imaging to examine the role of polycystin 1 and 2 in renal tubuologenesis. Pilot 3 proposes to test a novel glycolipid Inhibitor using the animal models and expertise provided by Core C. Through expanded interdisciplinary science collaborations, we hope to catalyze the translation of biomedical discoveries that slow down or prevent progression of polycystic kidney disease and its consequences. Public Health Relevance: The Polycystic Kidney diseases are a common group of disorders that are a leading cause of end stage renal disease. Despite many advances over the past several years, there is still no cure. We expect that this Core Center will provide the tools and expertise to facilitate collaborative PKD research leading to enhanced understanding of disease pathogenesis and innovative therapeutic approaches.

描述，总体（由申请人提供）： 在此提案中，我们将建立约翰·霍普金斯PKD研究和临床核心中心（JH-PKD 中心），将为国家和国际研究基础提供独特的资源和专业知识。该中心利用约翰·霍普金斯（Johns Hopkins）的PKD研究的悠久传统以及我们作为全面的PKD中心的独特地位。该中心的目标是1）为国家和国际研究人员提供艺术的试剂和专业知识，以促进与PKD相关的研究，2）为非PKD研究者提供试剂和专业知识，以消除与PKD相关的研究的障碍，以消除与PKD研究社区之间的开放，以促进PKD研究社会的开放，从而促进了研究互动，以实现研究的互动，以实现4），4）4）为了研究问题，5）为初级调查人员提供飞行员和可行性资金，以支持创新的询问线，并向PKD领域招募新的专业知识，6）与其他PKD中心和NIDDK合作，以确保资源有效地使用刺激PKD转换研究的目标有效地使用。 JH-PKD中心将包含一个管理核心（核心A）和4个生物医学核心资源，包括1）抗体验证和矢量学（核心B），2）鼠标模型和生物库（核心C）3）细胞工程（核心D）和4个）临床和翻译核心资源（核心E）。第一年选择的试点研究紧密关注核心资源，并在不同职业阶段招募3名新调查员到PKD领域。飞行员1将检查对PKD临床研究的态度态度的种族差异。试点2将应用尖端分子工具进行活细胞成像，以检查多囊蛋白1和2在肾小管肾小管术中的作用。 Pilot 3建议使用Core C提供的动物模型和专业知识来测试一种新型的糖脂抑制剂。通过扩展的跨学科科学合作，我们希望催化生物医学发现的翻译，这些发现减慢或防止多囊性肾脏疾病的发展及其后果。 公共卫生相关性：多囊性肾脏疾病是一群常见的疾病，是终结肾脏疾病的主要原因。尽管过去几年取得了许多进步，但仍然无法治愈。我们预计，这个核心中心将提供工具和专业知识，以促进协作性PKD研究，从而增强对疾病发病机理和创新治疗方法的了解。