Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)

马里兰州多囊肾病研究与转化核心中心 (MPKD-RTCC)

• 批准号: 10693919
• 负责人: Terry J Watnick
• 金额: $ 88.43万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-24 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693919
• 关键词: Address; Antibodies; Area; Baltimore; Basic Science; Biomedical Research; Cell Culture Techniques; Clinical; Collaborations; Communities; Country; Discipline; Disease; Disease Progression; End stage renal failure; Future; Generations; Goals; Institution; Interdisciplinary Study; Knowledge; Leadership; Maryland; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Polycystic Kidney Diseases; Reagent; Research; Research Personnel; Resources; Science; Signal Transduction; Stretching; Therapeutic; Therapeutic Agents; Translational Research; Translations; Universities; Vision; autosome; base; biobank; cellular engineering; clinical investigation; experience; innovation; interdisciplinary collaboration; medical schools; mouse model; prevent; prospective; side effect; student participation; success; therapeutic target; vector

Overall Project Summary In this application we establish the Maryland Polycystic Kidney Disease (PKD) Research and Translation Core Center (MPKD-RTCC). The mission of this Center is to facilitate translational and basic research in the field of polycystic kidney disease and related disciplines by providing unique resources, reagents and expertise to a broad base of investigators. This proposal capitalizes on a long tradition of PKD research by MPKD-RTCC investigators who have been at the forefront of PKD science for the past two decades. The Center consists of 4 highly collaborative and integrated biomedical research cores that together will distribute an essential “toolbox” of reagents and expertise tailored specifically to PKD research. The MPKD-RTCC cores include 1) Antibody and Vector 2) Mouse Models and Biobank 3) Cell Culture and Engineering and 4) Clinical and Translation. Each core addresses a critical need in the PKD research pipeline, stretching from basic to clinical investigation. In addition, MPKD-RTCC core leaders will pioneer solutions to perceived needs among PKD Researchers by expanding in innovative directions. We expect that this strategy will continue our proven track record of supporting high impact science across the country. These activities will be organized by an Administrative Core led by two experienced investigators who will leverage the resources of two outstanding research institutions in Baltimore, the University of Maryland Baltimore (UMB) and the Johns Hopkins School of Medicine. As a team they will drive the MPKD-RTCC’s fundamental commitment to the principle of collaborative science by streamlining SOPs for sharing high quality reagents and expertise, by integrating our the core’s activities and by coordinating collaboration with other RTCCs within the PKD Research Consortium. The Center’s Specific Aims are: 1) To provide critical state of the art reagents and expertise to a national group of PKD investigators 2) To provide critical state of the art reagents and expertise to non-PKD investigators in order to remove barriers to PKD related research 3) To develop innovative reagents and resources that will advance biomedical discoveries in the field of PKD 4) To drive collaboration between MPKD-RTCC Cores and other RTCCs within the PKD Research Consortium and 5) To partner with other RTCCs, the consortium steering committee including the NIDDK to achieve the overall goals of the PKD Research Consortium. Through expanded interdisciplinary collaborations, we hope to catalyze the translation of biomedical discoveries that will prevent progression of polycystic kidney disease and its consequences.

总体项目摘要 在此应用中，我们建立了马里兰州多囊肾脏疾病（PKD）研究和翻译核心 中心（MPKD-RTCC）。该中心的任务是促进该领域的翻译和基础研究 多囊肾脏疾病及相关学科通过提供独特的资源，试剂和专业知识 研究人员的广泛基础。该提议利用了MPKD-RTCC的PKD研究的悠久传统 在过去的二十年中一直处于PKD科学的最前沿的调查人员。中心由 4高度协作和综合的生物医学研究核心将共同分发重要的 针对PKD研究专门量身定制的试剂和专业知识的“工具箱”。 MPKD-RTCC内核包括1） 抗体和矢量2）小鼠模型和生物库3）细胞培养和工程以及4）临床和 翻译。每个核心都满足PKD研究管道的关键需求，从基本到临床延伸 投资。此外，MPKD-RTCC核心领导者还将在PKD中提倡解决需求的解决方案 通过朝着创新的方向扩展研究人员。我们预计该策略将继续我们的经过验证的轨道 支持全国高影响力科学的记录。这些活动将由 由两名经验丰富的调查人员领导的行政核心，他们将利用两个未偿还的资源 巴尔的摩，马里兰州巴尔的摩大学（UMB）和约翰·霍普金斯学校的研究机构 医学。作为一个团队，他们将推动MPKD-RTCC对原则的基本承诺 通过简化分享高质量试剂和专业知识的SOP，通过整合我们的合作科学 核心的活动以及通过与PKD研究联盟中其他RTCC的协调合作。 该中心的具体目的是：1）为国家群体提供最清晰的试剂和专业知识的关键状态 PKD调查人员2）为非PKD调查人员提供最清晰的试剂和专业知识的关键状态 为了消除与PKD相关研究的障碍3）开发创新试剂和资源 PKD 4）在PKD领域的提前生物医学发现，以推动MPKD-RTCC核心之间的合作 PKD研究财团内的其他RTCC和5）与其他RTCC合作，该联盟 指导委员会在内，包括NIDDK，以实现PKD研究联盟的整体目标。 通过扩大的跨学科合作，我们希望催化生物医学的翻译 可以防止多囊性肾脏疾病及其后果进展的发现。