National Coordinating Center (NCC) for the Polycystic Kidney Disease (PKD) Research and Translation Core Centers

国家多囊肾病 (PKD) 研究和转化核心中心协调中心 (NCC)

基本信息

批准号：
10687258
负责人：
Terry J Watnick
金额：
$ 89.21万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-20 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10687258
关键词：
Acceleration Address Autosomal Dominant Polycystic Kidney Belief Biological Models Collaborations Communication Communities Creativeness Critical Thinking Cyst Cystic Kidney Diseases Data Development Disease Education Educational Activities Evaluation Event Fostering Functional disorder Funding Funding Opportunities Genes Genomics Goals Human Information Dissemination Inherited Intervention Joints Kidney Failure Leadership Mission Patients Polycystic Kidney Diseases Positioning Attribute Reagent Research Research Personnel Resource Development Resource Sharing Resources Science Structure Talents Translational Research Translations United States National Institutes of Health cohesion cohort collaborative environment effective therapy experience improved innovation insight material transfer agreement new therapeutic target novel therapeutics programs public health relevance success symposium tool web site

项目摘要

Project Summary Polycystic Kidney Disease (PKD) is the most common inherited cause of renal failure worldwide. The genes responsible for the most frequent forms of PKD (PKD1, PKD2 and PKHD1) were identified over the past two decades. Progress over these years has led to improved tools for studying cyst formation and progression and these in turn have resulted in an improved understanding of PKD pathophysiology and, most recently, an approved therapy. Despite these advances, however, there is no intervention to halt cystic kidney disease or its systemic manifestations and there remains a pressing need for more effective treatments. In order to promote interdisciplinary and integrated approaches to the identification of novel therapeutic targets, an RFA has been issued to support PKD Research and Translation Core Centers (RTCCs) whose mission will be to develop innovative research tools. Here we establish a new National Coordinating Center (NCC) to provide highly organized administrative support to the RTCCs. We will implement a bold, innovative and outward- facing program that will facilitate collaboration and cohesion between the RTCCs and establish mechanisms for sharing of reagents and expertise broadly. The National Coordinating Center will seek to invigorate and energize research in PKD by supporting and expanding the community of PKD investigators, by promoting data driven science and by developing educational activities that encourage open and critical thinking and attract the brightest new talent to the study of PKD. Leadership of the National Coordinating Center will be provided by two investigators with an in-depth understanding of the PKD field and a deep belief in the importance of collaborative science. The NCC will support the goals of the PKD Research Consortium with the following Aims: 1) Convene the PKD Research Consortium Steering Committee to develop the program’s overall direction, to organize and execute program activities and to assist with broad dissemination of information 2) Develop a multipronged communication plan including an accessible web site for disseminating information about research resources 3) Facilitate collaboration between RTCCs by establishing a framework for joint development of resources 4) Facilitate broad sharing of resources across the consortium 5) Develop an educational program, including an annual scientific symposium that will encourage constructive discourse and diverse and creative approaches to PKD science. 6) Develop, support and execute a pilot and feasibility program that encourages new investigators (both early stage and established) to enter the field of PKD research. 7) Provide educational programming geared toward early stage investigators to foster the development of a new cohort of PKD researchers and leaders. In summary, the collaborative environment fostered by the NCC will catalyze advances that we expect will result in new insights into PKD pathobiology and new therapeutic options for patients with polycystic kidney disease.

项目摘要多环肾病（PKD）是全球肾衰竭的最常见原因在过去两个几十年来，这些年来，HASS的进步导致了研究囊肿形成和进展的工具反过批准的疗法，尽管有进步，但没有干预它的系统性表现和迫切需要更有效的治疗促进跨学科和综合方法来鉴定新的治疗剂目标，即RFA 已发行以支持PKD研究和翻译核心中心（RTCCS）开发创新的研究工具。对RTCC的高度有组织的行政支持。面对计划的计划将促进RTCC之间的协作和凝聚力并建立机制为了大致分享试剂和专业知识。通过促进PKD调查人员的支持和扩大PKD的研究，通过推广数据驱动科学并通过开发鼓励开放和批判性思维和思维的教育活动吸引PKD研究的最亮新人才。由两个调查人员对PKD领域的深入了解，对您有深刻的认识合作科学的重要性。以下目的：1）召集PKD研究联盟指导委员会开发该计划的总体方向，组织和执行计划激活，并协助广泛传播信息2）制定一个多收益的沟通计划，包括用于传播的可访问网站有关研究资源的信息3）通过建立框架来促进RTCC之间的合作对于资源的共同开发4）促进整个财团的广泛共享5）一个教育计划，包括鼓励建设性话语的年度科学研讨会以及PKD科学的多元化和创造性方法。鼓励新调查人员（早期和成立）进入PKD领域的计划研究。开发新的PKD研究人员和领导者。 NCC培养将促进我们期望的进步，这将导致洞察力见解病原体学以及针对多囊性肾脏疾病患者的新治疗选择。