EFFECT OF GLYCEMIC INDEX AND CEREAL FIBER ON VASCULAR ENDOTHELIAL FUNCTION

血糖指数和谷物纤维对血管内皮功能的影响

• 批准号: 7718573
• 负责人: GLENN A GAESSER
• 金额: $ 4.05万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718573
• 关键词: Adult; Adverse effects; Age; Analysis of Variance; Atherosclerosis; Blood Vessels; Cardiovascular system; Cereals; Clinical; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Diet; Endothelium; Fiber; Funding; Glycemic Index; Grant; Human; Institution; Invasive; Link; Measures; Mediating; Nitric Oxide; Research; Research Personnel; Resolution; Resources; Role; Source; Ultrasonography; United States National Institutes of Health; Vasodilator Agents; brachial artery; cardiovascular disorder risk; improved; in vivo Bioassay; mortality; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flow-mediated dilation (FMD) of the brachial artery using high-resolution ultrasound is a well accepted non-invasive bioassay for in vivo endothelium-generated nitric oxide (NO) in humans. NO has been characterized as a potent vasodilator, but NO also has a considerable role in maintaining healthy endothelium and inhibiting key steps in the development, progression, and clinical manifestations of atherosclerosis. The postprandial state may be critical in the development of atherosclerosis. Diets high in cereal fiber have been linked to reduced risk of cardiovascular disease. Conversely, high-glycemic index (GI) diets have been linked to increased cardiovascular mortality. We postulate that the beneficial effect of cereal fiber on FMD is stronger than the potentially adverse effect of GI. Therefore, we hypothesize that breakfast meals high in cereal fiber will acutely improve FMD, regardless of GI. By contrast, we hypothesize that a high-GI breakfast meal that is low in cereal fiber will impair FMD. We also hypothesize that a breakfast meal that is low in both GI and cereal fiber will have no effect on postprandial FMD. Brachial artery flow-mediated dilation (FMD) will be assessed before and at 2 h and 4 h after each of four breakfast meals [(1) High-fiber, Low GI; (2) High-fiber, High-GI; (3) Low-fiber, Low-GI; (4) Low-fiber, High-GI] using high-resolution ultrasound and edge-detection software in healthy adults ages 18-64. Analysis of variance with repeated measures will be used to assess differences in FMD in response to the meal challenges.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用高分辨率超声的流动介导的肱动脉的扩张（FMD）是人体内皮内皮产生的一氧化氮（NO）的良好接受的非侵入性生物测定。 NO已被认为是有效的血管扩张剂，但NO在维持健康的内皮和抑制动脉粥样硬化的发育，进展和临床表现方面也具有重要作用。 餐后状态对于动脉粥样硬化的发展至关重要。 高谷物纤维的饮食与降低心血管疾病的风险有关。 相反，高血糖指数（GI）饮食与心血管死亡率的增加有关。 我们假设谷物纤维对FMD的有益作用比GI的潜在不利影响更强。 因此，我们假设在谷物纤维中高的早餐餐将急性改善FMD，而不论GI如何。 相比之下，我们假设谷物纤维低的高gi早餐餐会损害FMD。 我们还假设，胃肠道和谷物纤维都低的早餐餐对餐后FMD没有影响。 在四种早餐餐中的每一小时，每个早餐后，臂动脉流介导的扩张（FMD）将在2小时和4小时内进行评估[（1）高纤维，低GI； （2）高纤维高-GI； （3）低纤维，低gi； （4）在18-64岁的健康成年人中使用高分辨率超声和边缘检测软件的低纤维高-GI]。 通过重复测量的方差分析将用于评估FMD响应餐食挑战的差异。