HIGH-COMPLEX-HIGH-REFINED-CHO MEALS, AND LOW-CHO MEALS ON ENDOTHELIAL FUNCTION

高复合、高精制膳食和低膳食对内皮功能的影响

• 批准号: 7718571
• 负责人: GLENN A GAESSER
• 金额: $ 11.38万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718571
• 关键词: Age; Analysis of Variance; Atherosclerosis; Attenuated; Carbohydrates; Cereals; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Diet; Endothelium; Fiber; Funding; Grant; Human; Impairment; Institution; Invasive; Link; Measures; Mediating; Nitric Oxide; Overweight; Participant; Research; Research Personnel; Resolution; Resources; Risk; Role; Source; Ultrasonography; United States National Institutes of Health; Vasodilator Agents; brachial artery; cardiovascular disorder risk; improved; in vivo Bioassay; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flow-mediated dilation (FMD) of the brachial artery using high-resolution ultrasound is a well accepted non-invasive bioassay for in vivo endothelium-generated nitric oxide (NO) in humans. NO has been characterized as a potent vasodilator, but NO also has a considerable role in maintaining healthy endothelium and inhibiting key steps in the development, progression, and clinical manifestations of atherosclerosis. Because the postprandial state may be critical in the development of atherosclerosis, and because diets high in cereal fiber have been linked to reduced risk of cardiovascular disease, we hypothesize that a high-carbohydrate, high-fiber meal would acutely improve FMD. By contrast, we hypothesize that a low-carbohydrate meal will impair FMD, and that a high-carbohydrate, low-fiber meal will have no effect on FMD. We also hypothesize that the addition of a high-fiber breakfast cereal to the low-carbohydrate meal will attenuate the impairment of FMD observed after the low-carbohydrate meal. Brachial artery flow-mediated dilation (FMD) will be assessed before and at 2 h and 4 h after each of four breakfast meals (high-carbohydrate, high-fiber; high-carbohydrate, low-fiber; low-carbohydrate, low-fiber; low-carbohydrate, high-fiber) using high-resolution ultrasound and edge-detection software in 12 participants ages 8-17 who are overweight or at-risk for overweight, 12 participants ages 18-64, and 12 participants ages 65 and older. Analysis of variance with repeated measures will be used to assess differences in FMD in response to the meal challenges.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用高分辨率超声的流动介导的肱动脉的扩张（FMD）是人体内皮内皮产生的一氧化氮（NO）的良好接受的非侵入性生物测定。 NO已被认为是有效的血管扩张剂，但NO在维持健康的内皮和抑制动脉粥样硬化的发育，进展和临床表现方面也具有重要作用。 由于餐后状态可能在动脉粥样硬化的发展中至关重要，并且由于谷物纤维高的饮食与降低心血管疾病的风险有关，因此我们假设高碳水化合物的高纤维粉将急性改善FMD。 相比之下，我们假设低碳水化合物会损害FMD，而高碳水化合物的低纤维餐将不会对FMD产生影响。 我们还假设在低碳水化合物粉中添加高纤维早餐谷物会减轻低碳水化合物粉后观察到的FMD损害。四顿早餐餐（高碳水化合物，高纤维，高纤维水域；高碳水化合物，低纤维，低纤维，低纤维，低纤维；低碳水化合物，高纤维，高纤维，高纤维）使用高分辨率的超级抗距离的甲型拔出术，将在四种早餐餐前和12参与者中，将在四种早餐餐（高碳水化合物；高碳水化合物，低纤维，低纤维，低纤维，低纤维，低纤维，低纤维）中，将在四种早餐（高碳水化合物；高碳水化合物；高纤维）中，使用高分辨率的甲型拔出式训练，将在2小时和4小时内进行评估。超重，12名18-64岁的参与者和65岁及65岁以上的参与者。 通过重复测量的方差分析将用于评估FMD响应餐食挑战的差异。