LOW-CHO & HIGH-CHO, HIGH-FIBER DIETS & RISK MARKERS FOR THE METABOLIC SYNDROME

低CHO

• 批准号: 7606693
• 负责人: GLENN A GAESSER
• 金额: $ 3.21万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606693
• 关键词: Arteries; Blood; Caloric Restriction; Calories; Carbohydrates; Cardiovascular system; Cholesterol; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Condition; Crossover Design; Daily; Diet; Eating; Fatty acid glycerol esters; Fiber; Food; Forearm; Funding; Glucose; Grant; Health; Heart Diseases; Inflammation; Institution; Insulin; Metabolic; Metabolic syndrome; Outcome Measure; Participant; Procedures; Proteins; Randomized; Research; Research Personnel; Resources; Risk Marker; Source; Triglycerides; Ultrasonography; United States National Institutes of Health; Week; Woman; cardiovascular disorder risk; day; diabetes risk; improved; insulin sensitivity; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to compare a low-carbohydrate diet with high-carbohydrate, high-fiber diet-with no emphasis on calorie restriction--with regard to insulin sensitivity and blood markers for cardiovascular disease risk in men and women with the metabolic syndrome. In a randomized crossover design, men and women with the metabolic syndrome (i.e., a metabolic condition associated with increased risk for diabetes and heart disease) will consume each of two diets: a low-carbohydrate diet (15-20% carbohydrate; 55-60% fat; 25-30 protein) and a high-carbohydrate, high-fiber diet (55-60% carbohydrate; 20-25% fat; 15-20% protein; > 30 grams fiber per day). Each diet period will last 4 weeks, with a 4-6 week wash-out period. All meals will be prepared in the General Clinical Research Center (GCRC) kitchen for pick-up three days per week by the participants, and will contain more than enough calories to meet daily energy needs. Participants will be instructed to eat only until no longer hungry, and to return uneaten food to the GCRC. We hypothesize that that the high-carbohydrate, high-fiber diet will significantly improve insulin sensitivity and enhance cardiovascular health, and the low-carbohydrate diet will not. Outcome measures include blood levels of insulin, glucose, cholesterol, triglycerides, and several markers of inflammation, as well as an ultrasound procedure to examine endothelial function of a forearm artery.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是将低碳水化合物饮食与高碳水化合物，高纤维饮食（不强调卡路里限制）进行比较 - 考虑到患有代谢综合征的男性和女性心血管疾病风险的胰岛素敏感性和血液标记。 在随机的跨界设计中，具有代谢综合征的男性和女性（即与糖尿病和心脏病风险增加有关的代谢疾病）将消耗两种饮食中的每一种：低碳水化合物饮食（15-20％碳水化合物（15-20％）（55-60％脂肪； 55-60％脂肪； 25-30蛋白质）和高碳水化合物，高碳水化合物，高含量5.5％，55％ - 55％ - 含量为55％carbo-filedrate; 55％carbo-carbo-filedrate; 55％carbo-Felthrate; 55％carbo-carbo-Felthrate; 55％car; 15-20％的蛋白质； 每个饮食期间将持续4周，并进行4-6周的洗涤期。 所有餐点都将在一般临床研究中心（GCRC）厨房中准备，参与者每周三天，并含有足够的卡路里来满足日常能源需求。 参与者将被指示只吃进食，直到不再饿，并将未食用的食物退还给GCRC。 我们假设高碳水化合物高纤维饮食将显着提高胰岛素敏感性并增强心血管健康，而低碳水化合物饮食将无法。 结果指标包括胰岛素，葡萄糖，胆固醇，甘油三酸酯和几种炎症标记的血液水平，以及检查前臂动脉内皮功能的超声手术。