IMMUNE DYSREGULATION IN ALLERGIC ASTHMA

过敏性哮喘的免疫失调

• 批准号: 7716559
• 负责人: Mark R Schuyler
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716559
• 关键词: Basophils; Computer Retrieval of Information on Scientific Projects Database; Coupling; Excision; Extrinsic asthma; Funding; Grant; IgE; Immune; Institution; Lung; Measures; Mediating; Olizumab; Phosphotransferases; Research; Research Personnel; Resources; Signal Transduction; Source; Testing; United States National Institutes of Health; Withdrawal; mast cell

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that treating mild asthmatics with rhumAb-E25 reduced Fc&RI expression and signaling activity in lung mast cells as it does in basophils and to determine if IgE removal impairs basophil Fc&RI stability and Fc&RI-kinase coupling. a. To measure effects of rhumAb25 treatment and withdrawal on Fc&RI levels and Fc&RI-mediated degranulation in the lung mast cells and blood basophils of mild asthmatics. b. To explore effects of IgE removal on the stability of Fc&RI subunit interactions and on Fc&RI-kinase coupling in basophils.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将检验以下假设：用若晶鼠晶状体治疗轻度哮喘患者与嗜碱性粒细胞一样降低了肺肥大细胞中FC和RI的表达和信号传导活性，并确定IgE去除率是否损害了粒细胞FC和RI稳定性以及FC和Ri-Kinase coupling。 一个。测量Rhumab25治疗和戒断对FC和RI水平的影响以及FC和RI介导的肺肥大细胞和轻度哮喘患者血液嗜碱性的脱粒。 b。探索去除IgE对FC和RI亚基相互作用以及嗜碱性粒细胞中FC和RI-Kinase耦合的稳定性的影响。