IMMUNE DYSREGULATION IN ADULTS AND CHILDREN WITH ASTHMA

患有哮喘的成人和儿童的免疫失调

• 批准号: 7606844
• 负责人: Mark R Schuyler
• 金额: $ 6.22万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606844
• 关键词: Adult; Antibodies; Asthma; Blood; Breathing; Bronchoalveolar Lavage Fluid; Budesonide; CD4 Positive T Lymphocytes; Child; Computer Retrieval of Information on Scientific Projects Database; Exposure to; Extrinsic asthma; Funding; Grant; Immune; Institution; Keyhole Limpet Hemocyanin; Lung; Nedocromil; Patients; Production; Purpose; Research; Research Personnel; Resources; Source; United States National Institutes of Health; cytokine; peripheral blood; response; Adult; Antibodies; Asthma; Blood; Breathing; Bronchoalveolar Lavage Fluid; Budesonide; CD4 Positive T Lymphocytes; Child; Computer Retrieval of Information on Scientific Projects Database; Exposure to; Extrinsic asthma; Funding; Grant; Immune; Institution; Keyhole Limpet Hemocyanin; Lung; Nedocromil; Patients; Production; Purpose; Research; Research Personnel; Resources; Source; United States National Institutes of Health; cytokine; peripheral blood; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to compare blood and bronchoalveolar lavage fluid (BALF) anti-KLH (keyhole limpet hemocyanin) antibody isotype profiles and peripheral blood CD4+ T cell cytokine production after systemic or pulmonary exposure to KLH in patients with atopic asthma compared with healthy control subjects. This study will also determine if the anti-KLH antibody isotype and CD4 response to pulmonary or systemic KLH in asthmatics can be modulated by pretreatment with inhaled nedocromil or glucocorticosteroids (budesonide).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是比较血液和支气管肺泡灌洗液（BALF）抗KLH（钥匙孔Limpet Hemocyanin）抗体同种型概况以及与健康对照受试者相比，全身性或肺部对KLH的全身性或肺部暴露后，全身性或肺部后产生的外周血CD4+ T细胞因子产生。这项研究还将确定是否可以通过对吸入的尼迪克罗尼尔或糖皮质固醇（Budesonide）预处理哮喘中的抗-KLH抗体同种型和CD4对哮喘中肺或全身性KLH的反应。