Body Composition and Disability in RA and SLE

RA 和 SLE 的身体成分和残疾

• 批准号: 7612006
• 负责人: Patricia P Katz
• 金额: $ 6.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7612006
• 关键词: Accounting; Address; Affect; Age; Area; Behavioral; Blood specimen; Body Composition; Body fat; Body mass index; Cachexia; Clinical; Clinical Research; Cognitive; Complex; Condition; Conflict (Psychology); Data; Derivation procedure; Development; Disease; Eating; Ethnic Origin; Evaluation; Fatty acid glycerol esters; General Population; Height; Home environment; Home visitation; House Call; Impairment; Incidence; Individual; Inflammatory; Intervention; Interview; Knowledge; Leisure Activities; Life; Light; Lupus; Lupus Erythematosus; Maintenance; Measurement; Measures; Mediating; Methodology; Modeling; Muscle; Numbers; Obesity; Outcome Study; Participant; Pathology; Pathway interactions; Patient Self-Report; Personal Satisfaction; Persons; Physical Function; Physical activity; Prevalence; Process; Protocols documentation; Range; Research; Rheumatism; Rheumatoid Arthritis; Risk; Risk Factors; Role; San Francisco; Severities; Severity of illness; Sex Functioning; Sterile coverings; Systemic Lupus Erythematosus; Telephone Interviews; Testing; Therapeutic; Treatment Factor; Value of Life; Variant; Visit; Weight; Work; base; body system; cognitive function; cohort; cytokine; disability; member; muscle strength; psychologic; psychosocial; social; wasting

The overarching aim of this study is to estimate the role of body composition in the development of functional imitations and disability in both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), within the context of a well-established model of disablement. Use of this model will facilitate a greater understanding of the role of body composition in the development of disability, taking into account other disease, therapeutic, demographic, psychosocial, and behavioral factors that may contribute to or protect from disability. This project also represents the first attempt to characterize disability among persons with SLE across a wide range of life activities using the "valued life activities" model of disability. Specific aims are to: (1) examine the role of body composition in development of functional limitations and disability in SLE and RA, using an existing model of disablement; (2) identify risk and protective factors that interact with body composition in the development of functional limitations and disability, or the maintenance of function and avoidance of disability, in RA and SLE; and (3) estimate the prevalence and incidence of disability in a wide range of life activities in a large group of individuals with SLE. Subjects for the proposed study will be members of the existing UCSF RA Panel and Lupus Outcomes Study (LOS). Existing study protocols include annual telephone interviews with the cohorts through 2008, with an additional two years proposed in the Methodology Core of this application. The proposed study will build upon this by adding project-specific measures to the annual telephone interviews, and adding two in-person assessments at the UCSF General Clinical Research Center (GCRC) for a subset of subjects from each cohort. At the GCRC visit, we will conduct an assessment of body composition, conduct testing of muscle strength and physical function, obtain blood samples for measurement of inflammatory and other markers, obtain an estimate of habitual physical activity, and perform a cognitive function evaluation. Analyses, combining interview and home visit data, will focus on 3 major areas - (1) describing body composition findings in the 2 cohorts, (2) estimating the relationship between body composition and functional limitations and disability in the 2 cohorts; and (3) identification of factors that may modify or mediate the relationship between body composition and either functional limitations or disability. Analyses will also identify the correlation between self-reported information from interview data (e.g., body mass index calculated from self-reported height and weight) with that gathered from the GCRC assessment. The findings from this study will provide information that can assist in identifying individuals with RA and SLE who may be at greatest risk of disability, and estimating the effect of intervening factors on the development of disability.

这项研究的总体目的是估计身体成分在功能发展中的作用 类风湿关节炎（RA）和全身性红斑狼疮（SLE）的模仿和残疾 公认的残疾模型的背景。使用此模型将有助于更大的 理解身体成分在残疾发展中的作用，考虑到其他 疾病，治疗性，人群，社会心理和行为因素，可能有助于或保护 来自残疾。该项目还代表了表征与患者之间残疾的首次尝试 使用“有价值的生活活动”模型，在广泛的生活活动中进行了SLE。具体目标 是：（1）检查身体成分在功能局限性和残疾中的作用 和RA，使用现有的残疾模型； （2）确定与身体相互作用的风险和保护因素 功能局限性和残疾的发展中的组成，或维护功能和 在RA和SLE中避免残疾； （3）估计宽阔的残疾患病率和发病率 大量SLE的人的生活活动范围。拟议研究的受试者将是 现有的UCSF RA面板和狼疮结果研究（LOS）的成员。现有的研究方案 在2008年之前包括与队列的年度电话采访，并提出了另外两年的建议 该应用程序的方法核心。拟议的研究将通过添加特定于项目的研究以此为基础 年度电话采访的措施，并在UCSF General中添加两次面对面评估 临床研究中心（GCRC），用于每个队列的一部分受试者。在GCRC访问中，我们将 对身体组成进行评估，肌肉力量和身体机能的进行测试， 获取血液样本以测量炎症和其他标记，获得习惯的估计值 体育锻炼并执行认知功能评估。分析，结合面试和家庭访问 数据将重点关注3个主要领域 - （1）描述2个队列中的身体成分发现，（2）估计 身体组成与功能局限性与残疾之间的关系； （3） 识别可能修改或介导身体成分之间关系的因素和 功能限制或残疾。分析还将确定自我报告的信息之间的相关性 从访谈数据（例如，根据自我报告的身高和体重计算出的体重指数） 从GCRC评估中收集。这项研究的发现将提供可以帮助的信息 识别患有RA和SLE的人，他们可能有最大的残疾风险，并估算 介入残疾发展的因素。