Methodology Core

方法论核心

• 批准号: 8293901
• 负责人: Patricia P Katz
• 金额: $ 79.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-20 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8293901
• 关键词: Biological Assay; Clinical; Clinical Research; Collaborations; Collection; Cost Sharing; Data; Data Analyses; Data Collection; Data Quality; Data Sources; Development; Device or Instrument Development; Discipline; Education; Environment; Ethnic Origin; Extramural Activities; Faculty; Fostering; Funding; Genotype; Goals; Healthcare; Individual; Interview; Laboratories; Language; Leadership; Longitudinal Studies; Lupus; Maintenance; Medical; Mentorship; Methodology; Methods; Mission; Modality; Monitor; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Outcome; Outcome Study; Persons; Play; Quality Control; Race; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Role; Socioeconomic Status; Structure; Supervision; Surveys; Systemic Lupus Erythematosus; Training; Universities; cohort; data management; data sharing; distributed data; health disparity; improved; knowledge base; multidisciplinary; programs; protocol development; symposium

The Methodology Core of the proposed UCSF Multidisciplinary Clinical Research Center (MCRC) will serve as the hub for all MCRC projects and activities and allow the Center to pursue its program of research on health disparities in the rheumatic diseases. The primary goal of the Methodology Core is to advance clinical research at UCSF in outcomes of rheumatic conditions, building upon the existing structure developed during the current MCRC and expanded through additional extramural funding. A key component of the MCRC is the provision of shared data sources, allowing for cross-disciplinary collaborations and productive research programs of MCRC faculty and trainees. The specific aims of the Methodology Core are to: provide methodological and biostatistical support and oversight to MCRC projects and non-MCRC projects that use MCRC data sources; handle all data collection, including training and supervision of data collection staff; manage and distribute the data; provide guidance in appropriate analysis strategies for Core Unit data; and provide mentorship to trainees and junior faculty in developing and completing research projects. The shared primary data sources within the Methodology Core Unit are the Lupus Outcomes Study and the Rheumatoid Arthritis Outcomes Study. Both studies are longitudinal, incorporating such varied modalities of data collection as survey interviews, medical chart reviews, laboratory assays, in-person assessments, and genotyping. The cohorts are diverse in terms of race/ethnicity, socioeconomic status, and primary language The capacity to administer surveys in Spanish expands the MCRCs ability to understand the causes of disparities in onset, progression, health care, and outcomes of systemic lupus erythematosus and rheumatoid arthritis. The Methodology Core will fulfill its training mission through a broad range of activities, including individual mentorship, regular seminars in applied methods, and conferences devoted to clinical research in rheumatology. The Methodology Core leadership has a successful track record of fostering high quality research and attracting and advancing talented junior investigators. The educational component of the proposed Methodology Core will continue to support rigorous research methods in our trainees and foster collaborations across disciplines among investigators seeking to advance clinical research in rheumatology.

拟议的UCSF多学科临床研究中心（MCRC）的方法核心将作为所有MCRC项目和活动的枢纽，并允许该中心追求其关于风湿性疾病中健康差异的研究计划。该方法论核心的主要目标是在风湿性状况的结果上推进UCSF的临床研究，这是基于当前MCRC期间现有的结构，并通过额外的壁外资金扩展。 MCRC的一个关键组成部分是提供共享数据源，从而允许MCRC教师和受训者的跨学科合作和生产性研究计划。方法论核心的具体目的是：为使用MCRC数据源的MCRC项目和非MCRC项目提供方法论和生物统计学支持以及监督；处理所有数据收集，包括对数据收集人员的培训和监督；管理和分发数据；为核心单位数据提供适当的分析策略提供指导；并向受训者和初级教师提供指导，以开发和完成研究项目。 方法论核心单元中共有的主要数据源是狼疮结果研究和类风湿关节炎结果研究。这两项研究都是纵向的，将数据收集的各种方式纳入了调查访谈，医疗图表审查，实验室测定，面对面评估和基因分型。在种族/族裔，社会经济地位和初级语言方面，这些人群在西班牙语中进行调查的能力扩大了MCRC的能力，可以了解了解发作，进步，医疗保健以及全身性狼疮的成果的差异的原因。 方法核心将通过各种活动，包括个人指导，应用方法的定期研讨会以及致力于风湿病学临床研究的会议来实现其培训任务。方法论核心领导力取得了成功的记录，以促进高质量的研究并吸引和推进才华横溢的初级调查人员。拟议方法论核心的教育组成部分将继续支持我们的学员中的严格研究方法，并在寻求推进风湿病学临床研究的研究人员之间跨学科的合作。